Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Heiko Schadt"'
Autor:
Veronica V. Rezelj, Audrey Fischer, Francesca Moretti, Romel Rosales, Olivier Schwartz, Jiankun Lyu, Francois Pognan, Andrew C. Kruse, Kris M. White, Marco Vignuzzi, Heiko Schadt, Ziyang Zhang, Henry R. O’Donnell, Michael Schotsaert, Kevan M. Shokat, Tia A. Tummino, Adolfo García-Sastre, Nevan J. Krogan, Jean-Rene Galarneau, Raveen Rathnasinghe, Blandine Monel, Benoit Fischer, Briana L. McGovern, Assaf Alon, Matthew J. O’Meara, Thomas Vallet, Brian K. Shoichet, Sonia Jangra, Laszlo Urban
Publikováno v:
Science (New York, N.Y.)
Science (New York, N.Y.), vol 373, iss 6554
Science
Science, 2021, 373 (6554), pp.541-547. ⟨10.1126/science.abi4708⟩
Science (New York, N.Y.), vol 373, iss 6554
Science
Science, 2021, 373 (6554), pp.541-547. ⟨10.1126/science.abi4708⟩
International audience; Repurposing drugs as treatments for COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning with sigma receptor ligands and expanding to other drugs fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82c7138db547cd2c3c9cdbd9634a67d
https://doi.org/10.1126/science.abi4708
https://doi.org/10.1126/science.abi4708
Autor:
Christelle Stamm, Pierre Nimsgern, Thomas Knoepfel, Jasmin Wirth, Michel Niklaus, Diana Graus-Porta, Alberto Del Rio Espinola, Dario Sterker, Michael Kiffe, Nicolas Warin, Van Huy Luu, Mario Madoerin, Robert Mah, Jacqueline Kinyamu-Akunda, Robin Alec Fairhurst, Milen Todorov, Nicole Buschmann, Sebastien Ripoche, Nils Ostermann, Inga Galuba, Philippe Couttet, Catherine Leblanc, Alexandra Buhles, Jutta Blank, Flavia Adler, Wolfgang Jahnke, Chao Zou, Joerg Berghausen, Andreas Weiss, Pascal Furet, Heiko Schadt, Johannes Voshol, Markus Wartmann, Joerg Trappe
Publikováno v:
Journal of Medicinal Chemistry. 63:12542-12573
FGF19 signaling through the FGFR4/β-klotho receptor complex has been shown to be a key driver of growth and survival in a subset of hepatocellular carcinomas, making selective FGFR4 inhibition an attractive treatment opportunity. A kinome-wide seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e8386d5d1c6ff60ee10d825b90d6de
https://doi.org/10.1021/acs.jmedchem.0c01019
https://doi.org/10.1021/acs.jmedchem.0c01019
Autor:
Francois Pognan, Laszlo Urban, Heiko Schadt, Veronica V. Rezelj, Adolfo Garcia-Sastre, Olivier Schwartz, Blandine Monel, Nevan J. Krogan, Audrey Fischer, Ziyang Zhang, Brian K. Shoichet, Assaf Alon, Matthew J. O’Meara, Benoit Fischer, Kevan M. Shokat, Tia A. Tummino, Kris M. White, Marco Vignuzzi, Francesca Moretti, Jiankun Lyu, Thomas Vallet, Henry R. O’Donnell, Andrew C. Kruse
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Repurposing drugs as treatments for COVID-19 has drawn much attention. A common strategy has been to screen for established drugs, typically developed for other indications, that are antiviral in cells or organisms. Intriguingly, most of the drugs th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9022a1070b6eea488945070d6619e143
https://doi.org/10.1101/2021.03.23.436648
https://doi.org/10.1101/2021.03.23.436648
Autor:
Armin Wolf, Andreas Weiss, Markus Wartmann, Pascal Furet, William R. Sellers, Alexandra Buhles, Patrizia Barzaghi-Rinaudo, Heiko Schadt, Catherine Leblanc, Robin Alec Fairhurst, Robert Mah, Mario Centeleghe, Jacqueline Kinyamu-Akunda, Philippe Couttet, Jutta Blank, Michael Kiffe, Nicole Buschmann, Dario Sterker, Audrey Kauffmann, Masato Murakami, Youzhen Wang, Diana Graus Porta, Flavia Adler, Thomas Knoepfel, Francesco Hofmann, Christelle Stamm
Publikováno v:
Molecular cancer therapeutics. 18(12)
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and it is the third leading cause of cancer-related deaths worldwide. Recently, aberrant signaling through the FGF19/FGFR4 axis has been implicated in HCC. Here, we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ddb66996e7002e1cf057f14bbb2a55
https://pubmed.ncbi.nlm.nih.gov/31409633
https://pubmed.ncbi.nlm.nih.gov/31409633
Autor:
Terrilyn A. Richardson, Chi-Hse Teng, Audrey Fischer, Marianne Schwald, William Kluwe, Joerg Andreas Mahl, Robin Alec Fairhurst, Luigi Manenti, Francois Pognan, Armin Wolf, Gerd A. Kullak-Ublick, Mathilde Lienard, Jacqueline Kinyamu-Akunda, Elizabeth Skuba, Salah-Dine Chibout, Andreas Weiss, Kuno Wuersch, Philippe Couttet, Heiko Schadt, Diana Graus Porta, Corinne Emotte
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 163(1)
The FGF19- fibroblast growth factor receptor (FGFR4)-βKlotho (KLB) pathway plays an important role in the regulation of bile acid (BA) homeostasis. Aberrant activation of this pathway has been described in the development and progression of a subset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d746446e070550903c7f77a79f7ce1e
https://pubmed.ncbi.nlm.nih.gov/29432567
https://pubmed.ncbi.nlm.nih.gov/29432567
Autor:
Hong Lu, James N. VerHoeve, Suzanne T. Wolford, Terrilyn A. Richardson, Ursula Junker Walker, Wei Zhou, Paul E. Miller, Mikhail Akimov, William Kluwe, Axel Vicart, Danielle Roman, Heiko Schadt, Oliver C. Turner
Publikováno v:
Toxicology and applied pharmacology. 309
AUY922, a heat shock protein 90 inhibitor is associated with ocular adverse events (AEs). To provide a better understanding of ocular AEs in patients, 4 investigative studies were performed in a step-wise approach to assess retinal structure and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0c6116134e4c861f237cc22ca8da51
https://pubmed.ncbi.nlm.nih.gov/27576608
https://pubmed.ncbi.nlm.nih.gov/27576608
Autor:
Heiko Schadt, Salah-Dine Chibout, Michael Merz, Armin Wolf, Gerd A. Kullak-Ublick, Francois Pognan
Publikováno v:
Clinics and Research in Hepatology and Gastroenterology
Bile acid research has gained great momentum since the role of bile acids as key signaling molecules in the enterohepatic circulation was discovered. Their physiological function in regulating their own homeostasis, as well as energy and lipid metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf44f288c32bcad595dbf8d18198212
https://www.zora.uzh.ch/id/eprint/128518/
https://www.zora.uzh.ch/id/eprint/128518/
Autor:
Heiko Schadt, Francois Pognan, Armin Wolf, Daniel P. Stiehl, Salah-Dine Chibout, Audrey Dietz, Carlos A. Penno, Catia Vicente Vieira, Pierre Moulin, Marianne Schwald
Publikováno v:
Toxicology Letters. 229:S82
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e27ed0b8893986c400478d563ab4fcf
https://doi.org/10.1016/j.toxlet.2014.06.312
https://doi.org/10.1016/j.toxlet.2014.06.312
Autor:
Heiko, Schadt, Zuhal, Dincer, Marianne, Schwald, Audrey, Dietz, David, Ledieu, Andre, Cordier, Maria, Papoutsi, Ursula, Junker Walker, Fiona, Spence, Salah-Dine, Chibout, Armin, Wolf, Francois, Pognan
Publikováno v:
In Toxicology Letters 28 August 2013 221 Supplement:S172-S172