Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Heiko Rühl"'
Autor:
Heiko Rühl, Christian Bode, Tobias Becher, Sebastian Eckert, Ghaith Mohsen, Hannah L. McRae, Jens Müller, Sara Reda, Dirk Loßnitzer, Johannes Oldenburg, Christian Putensen, Bernd Pötzsch
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 1982 (2024)
Sepsis-associated coagulopathy increases risk of mortality. Impairment of the anticoagulant protein C (PC) pathway may contribute to the thrombotic phenotype in coronavirus disease 2019 (COVID-19) sepsis. This study assessed the functionality of this
Externí odkaz:
https://doaj.org/article/e0be3497eded43f498675cd68cd8484d
Autor:
Barbara Preisler, Behnaz Pezeshkpoor, Anja Merzenich, Sandra Ohlenforst, Heiko Rühl, Vytautas Ivaškevičius, Ute Scholz, Hagen Bönigk, Wolfgang Eberl, Barbara Zieger, Anna Pavlova, Johannes Oldenburg
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2384 (2024)
Congenital factor VII (FVII) deficiency is a rare genetic bleeding disorder characterized by deficient or reduced activity of coagulation FVII. It is caused by genetic variants in the F7 gene. We aimed to evaluate the rate of detection of pathogenic
Externí odkaz:
https://doaj.org/article/2b277c9610dd4be19f21749ffa1e7139
Autor:
Jens Müller, Nasim Shahidi Hamedani, Hannah L. McRae, Heiko Rühl, Johannes Oldenburg, Bernd Pötzsch
Publikováno v:
ACS Omega, Vol 7, Iss 35, Pp 30801-30806 (2022)
Externí odkaz:
https://doaj.org/article/bad1bd09eb4f4f59bb384dd9dfa4ea22
Autor:
Nasim Shahidi Hamedani, Felix Lucian Happich, Eva-Maria Klein, Heiko Rühl, Günter Mayer, Johannes Oldenburg, Jens Müller, Bernd Pötzsch
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Activated protein C (APC) is a serine protease with anticoagulant and cytoprotective activities which make it an attractive target for diagnostic and therapeutic applications. In this work, we present one-step activation of APC from a commer
Externí odkaz:
https://doaj.org/article/4baba1e3aa6644ab833ea7b0573e83b9
Autor:
Mehmet Oezkur, Sara Reda, Heiko Rühl, Nils Theuerkauf, Stefan Kreyer, Georg Daniel Duerr, Efstratios Charitos, Miriam Silaschi, Marta Medina, Sebastian Zimmer, Christian Putensen, Hendrik Treede
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Axial flow pumps are standard treatment in cases of cardiogenic shock and high-risk interventions in cardiology and cardiac surgery, although the optimal anticoagulation strategy remains unclear. We evaluated whether laboratory findings coul
Externí odkaz:
https://doaj.org/article/e41fa7b3c68d49f697022450a86f5623
Autor:
Sara Reda, Elena Thiele Serra, Jens Müller, Nasim Shahidi Hamedani, Johannes Oldenburg, Bernd Pötzsch, Heiko Rühl
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Elevated D-dimer levels during anticoagulant therapy with vitamin K antagonists (VKA) are associated with an increased risk of thrombosis. It has been hypothesized that elevated D-dimer levels in patients receiving direct oral anticoagulants (DOACs)
Externí odkaz:
https://doaj.org/article/0ca25618809d4bdaab99d15b0945837a
Autor:
Maryam Hejazi, Congcong Zhang, Sabrina B. Bennstein, Vera Balz, Sarah B. Reusing, Melissa Quadflieg, Keven Hoerster, Stefan Heinrichs, Helmut Hanenberg, Sebastian Oberbeck, Marcus Nitsche, Sophie Cramer, Rita Pfeifer, Pranav Oberoi, Heiko Rühl, Johannes Oldenburg, Peter Brossart, Peter A. Horn, Florian Babor, Winfried S. Wels, Johannes C. Fischer, Nina Möker, Markus Uhrberg
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The generation and expansion of functionally competent NK cells in vitro is of great interest for their application in immunotherapy of cancer. Since CD33 constitutes a promising target for immunotherapy of myeloid malignancies, NK cells expressing a
Externí odkaz:
https://doaj.org/article/4c25f962481b401c9f9ed4e85508f881
Autor:
Sara Reda, Heiko Rühl, Jana Witkowski, Jens Müller, Anna Pavlova, Johannes Oldenburg, Bernd Pötzsch
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Protein C (PC) activity tests are routinely performed in a thrombophilia workup to screen for PC deficiency. Currently used tests combine conversion of PC to activated PC (APC) by the snake venom Protac with subsequent APC detection through hydrolysi
Externí odkaz:
https://doaj.org/article/93cec0a03e7d45b7b14e348be6cbceaa
Autor:
Sara Reda, Eva Rudde, Jens Müller, Nasim Shahidi Hamedani, Johannes Oldenburg, Bernd Pötzsch, Heiko Rühl
Publikováno v:
Life, Vol 12, Iss 5, p 705 (2022)
Direct oral anticoagulants (DOACs) apixaban and rivaroxaban are broadly used in the management of venous thromboembolism (VTE). Although not routinely required, measurement of their plasma concentration is advised for an increasing number of indicati
Externí odkaz:
https://doaj.org/article/64bb620183cf4494ad7f028a59673110
Autor:
Sara Reda, Jens Müller, Anna Pavlova, Behnaz Pezeshkpoor, Johannes Oldenburg, Bernd Pötzsch, Heiko Rühl
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2119 (2021)
Inactivation of thrombin by the endogenous inhibitor antithrombin (AT) is a central mechanism in the regulation of hemostasis. This makes hereditary AT deficiency, which is caused by SERPINC1 gene mutations, a major thrombophilic risk factor. Aim of
Externí odkaz:
https://doaj.org/article/43582eb1a789437694d646001ad01dff