Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit

Autor: Heiko Löhr, Simon Hess, Mafalda M.A. Pereira, Philip Reinoß, Sandra Leibold, Christel Schenkel, Claudia M. Wunderlich, Peter Kloppenburg, Jens C. Brüning, Matthias Hammerschmidt

Publikováno v: Cell Reports, Vol 23, Iss 6, Pp 1728-1741 (2018)

Summary: Anorexigenic pro-opiomelanocortin (Pomc)/alpha-melanocyte stimulating hormone (αMSH) neurons of the hypothalamic melanocortin system function as key regulators of energy homeostasis, also controlling somatic growth across different species.

Externí odkaz: https://doaj.org/article/546212ab9c514f11989028ecbac57074

Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal

Autor: Matthias Hammerschmidt, M. Belén Pardi, Nicole Siegel, Antonia Marin-Burgin, M. Lucía Bartolomeu, Abel L. Carcagno, Guillermo M. Lanuza, Heiko Löhr, Daniela J. Di Bella

Publikováno v: Cell Reports, Vol 28, Iss 9, Pp 2264-2274.e3 (2019)
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Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system. Significant progress has been reached in understanding the mechanisms that govern neuronal diversity. Cerebrospinal fluid-cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2262e27457cae3c57732c2be603020b3
http://www.sciencedirect.com/science/article/pii/S2211124719310034

Hypothalamic Pomc Neurons Innervate the Spinal Cord and Modulate the Excitability of Premotor Circuits

Autor: Heiko Löhr, Matthias Hammerschmidt, Peter Kloppenburg, Marielle Minére, Patrick M. Fuller, Stephan Bremser, Elisa Ciglieri, Ansgar Büschges, Philip Reinoß, Andreas Klein, Henning Fenselau

Publikováno v: Curr Biol

Locomotion requires energy, yet animals need to increase locomotion in order to find and consume food in energy-deprived states. While such energy homeostatic coordination suggests brain origin, whether the central melanocortin 4 receptor (Mc4r) syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6187e165e64b432a28d74f70b0aa7bcb
https://doi.org/10.1016/j.cub.2020.08.103

Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis

Autor: Sandra Kröber, Alexander Hoischen, Maria Dimitriadi, Nasim Biglari, Matthias Hammerschmidt, Anne C. Hart, Irmgard Hölker, Gudrun Nürnberg, Peter Kloppenburg, Michael Walter, Miriam Peters, Frank Rigo, C. Frank Bennett, Kathryn J. Swoboda, Vanessa Grysko, Brunhilde Wirth, Seyyedmohsen Hosseinibarkooie, Anna Kaczmarek, Peter Nürnberg, Aaradhita Upadhyay, Christian Gilissen, Lutz Garbes, Svenja Schneider, Cathleen Bradler, Min Jeong Kye, Markus Riessland, Heiko Löhr, Laura Torres-Benito

Publikováno v: American Journal of Human Genetics, 100, 297-315
American Journal of Human Genetics, 100, 2, pp. 297-315

Item does not contain fulltext Homozygous SMN1 loss causes spinal muscular atrophy (SMA), the most common lethal genetic childhood motor neuron disease. SMN1 encodes SMN, a ubiquitous housekeeping protein, which makes the primarily motor neuron-speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4aacabf76665c5948ca043bc6b6389
http://hdl.handle.net/2066/170271

Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis

Autor: Matthias Hammerschmidt, Marysia Placzek, Hans-Martin Pogoda, Fang Liu, Heiko Löhr, Kyoji Ohyama, Caroline A. Pearson

Publikováno v: Development (Cambridge, England)

The neurohypophysis is a crucial component of the hypothalamo-pituitary axis, serving as the site of release of hypothalamic neurohormones into a plexus of hypophyseal capillaries. The growth of hypothalamic axons and capillaries to the forming neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4882b99354297f4a0fad9321a6ce01f
https://doi.org/10.1242/dev.080226