Zobrazeno 1 - 10
of 676
pro vyhledávání: '"Heiko J. Luhmann"'
Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control
Autor:
Manuel Bange, Gabriel Gonzalez-Escamilla, Damian M. Herz, Gerd Tinkhauser, Martin Glaser, Dumitru Ciolac, Alek Pogosyan, Svenja L. Kreis, Heiko J. Luhmann, Huiling Tan, Sergiu Groppa
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Increasing evidence suggests a considerable role of pre-movement beta bursts for motor control and its impairment in Parkinson’s disease. However, whether beta bursts occur during precise and prolonged movements and if they affect fine mot
Externí odkaz:
https://doaj.org/article/e18b26b7de694c38b58514713079f984
Autor:
Margaryta Tevosian, Hristo Todorov, Ermelinda Lomazzo, Laura Bindila, Natsuo Ueda, Davide Bassetti, Davide Warm, Sergei Kirischuk, Heiko J. Luhmann, Susanne Gerber, Beat Lutz
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Anandamide (AEA) is an endogenous ligand of the cannabinoid CB1 and CB2 receptors, being a component of the endocannabinoid signaling system, which supports the maintenance or regaining of neural homeostasis upon internal and external challe
Externí odkaz:
https://doaj.org/article/dcd9daa4df0e43a6967186c58bc56247
Autor:
Fahimeh Yeganeh, Beate Knauer, Roberta Guimarães Backhaus, Jenq-Wei Yang, Albrecht Stroh, Heiko J. Luhmann, Maik C. Stüttgen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Inhibitory interneurons play central roles in the modulation of spontaneous network activity and in processing of neuronal information. In sensory neocortical areas, parvalbumin-positive (PV+) GABAergic interneurons control the representatio
Externí odkaz:
https://doaj.org/article/ca7c57ce66b5457686239340b5fc9851
Autor:
Aniello Lombardi, Qiang Wang, Maik C. Stüttgen, Thomas Mittmann, Heiko J. Luhmann, Werner Kilb
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionShort-term synaptic plasticity (STP) is a widespread mechanism underlying activity-dependent modifications of cortical networks.MethodsTo investigate how STP influences excitatory and inhibitory synapses in layer 2/3 of mouse barrel corte
Externí odkaz:
https://doaj.org/article/57031eb49d554a0e814430de32b27907
Autor:
Renata Rose, Nicolas Peschke, Elena Nigi, Márton Gelléri, Sandra Ritz, Christoph Cremer, Heiko J. Luhmann, Anne Sinning
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Single-molecule imaging in developing cortical neurons shows that chromatin compaction precedes apoptosis and is an essential part of it, but can be uncoupled from the following apoptotic process.
Externí odkaz:
https://doaj.org/article/abb06b97103646b889f1ae801c814e5d
Autor:
Heiko J. Luhmann
Publikováno v:
Neurobiology of Disease, Vol 178, Iss , Pp 106018- (2023)
This review article gives an overview on the molecular, cellular and network mechanisms underlying focal seizures in neocortical networks with developmental malformations. Neocortical malformations comprise a large variety of structural abnormalities
Externí odkaz:
https://doaj.org/article/cf167c03a365441099f00f13a95a4d17
Publikováno v:
Research, Vol 6 (2023)
Translational experimental approaches that help us better trace Parkinson’s disease (PD) pathophysiological mechanisms leading to new therapeutic targets are urgently needed. In this article, we review recent experimental and clinical studies addre
Externí odkaz:
https://doaj.org/article/5846ab467afc4f85984d5d30103b3c69
Publikováno v:
Frontiers in Neuroanatomy, Vol 17 (2023)
The development of functionally interconnected networks between primary (S1), secondary somatosensory (S2), and motor (M1) cortical areas requires coherent neuronal activity via corticocortical projections. However, the anatomical substrate of functi
Externí odkaz:
https://doaj.org/article/703837bdd2754352a52652e80cde218d
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract How information in the nervous system is encoded by patterns of action potentials (i.e. spikes) remains an open question. Multi-neuron patterns of single spikes are a prime candidate for spike time encoding but their temporal variability req
Externí odkaz:
https://doaj.org/article/2b78186dac124be09ddbe822363fcf9e
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Spontaneous activity plays a crucial role in brain development by coordinating the integration of immature neurons into emerging cortical networks. High levels and complex patterns of spontaneous activity are generally associated with low rates of ap
Externí odkaz:
https://doaj.org/article/58221a6d0e814bc0a5f52f537f2b107e