Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Heiko Funke-Kaiser"'
Autor:
Daniela Zaade, Jennifer Schmitz, Eileen Benke, Sabrina Klare, Kerstin Seidel, Sebastian Kirsch, Petra Goldin-Lang, Frank S Zollmann, Thomas Unger, Heiko Funke-Kaiser
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57674 (2013)
The (pro)renin receptor ((P)RR) signaling is involved in different pathophysiologies ranging from cardiorenal end-organ damage via diabetic retinopathy to tumorigenesis. We have previously shown that the transcription factor promyelocytic leukemia zi
Externí odkaz:
https://doaj.org/article/2c4c7e62db0c438c9e1aa4b4b678ae1e
Autor:
Heiko Funke-Kaiser, Kerstin Seidel, Jennifer Schmitz, Thomas Unger, Daniela Zaade, Heike Meyborg, Frank S. Zollmann, Sabrina Klare, Eva Schrezenmeier, Sebastian Kirsch, Philipp Stawowy, Sarah Bernhard, Petra Goldin-Lang
Publikováno v:
Biochemical Pharmacology, 84(12), 1643-1650. Elsevier Science
The (pro)renin receptor ((P)RR) and Wnt signalling are both involved in different diseases ranging from cardiac and renal end-organ damage to cancer. (P)RR function involves signalling via the transcription factor promyelocytic leukemia zinc finger p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc34836bc55f2b86fcb0d6e333be8f7
https://doi.org/10.1016/j.bcp.2012.09.020
https://doi.org/10.1016/j.bcp.2012.09.020
Autor:
Christian Böhm, Kai Kappert, Heiko Funke-Kaiser, Kerstin Seidel, Frank S. Zollmann, Sebastian Kirsch, Eva Schrezenmeier, Werner Skuballa, Kristin Schmerbach, Melanie Kroh, Sabrina Klare, Thomas Unger, Petra Goldin-Lang, Sarah Bernhard
Publikováno v:
Pharmacology, 90(5-6), 307-315. S. Karger AG
Background/Aims: Putative in vitro-in vivo correlations of pharmacokinetic (PK) parameters are regarded as a prerequisite to filter hits derived from high-throughput screening (HTS) approaches for subsequent murine in vivo PK studies. Methods: In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01367c5b49c33ac39946cd7e633824c
https://cris.maastrichtuniversity.nl/en/publications/cfecb64f-b2c8-44b4-a108-55aadeeb6618
https://cris.maastrichtuniversity.nl/en/publications/cfecb64f-b2c8-44b4-a108-55aadeeb6618
Autor:
Keisuke Ishizawa, Jung Sook Suh, Maria Frosini, Masaki Imanishi, Sarah J. Mitchell, Kai Kappert, Linyong Xu, Georg Dechant, Sui-Lin Mo, Heiko Funke-Kaiser, Piero Tanganelli, Koichiro Tsuchiya, M. Zeitlinger, Ludo Willems, Josef Donnerer, Jae-Wook Oh, Z. Erdogan, A. Burian, Ingrid Liebmann, Ignacio Valencia-Hernández, Bosheng Huang, Christian Humpel, Min-Ji Song, Constanze M. Barwitz, Licht Miyamoto, Giampietro Sgaragli, José Carlos Villegas-Bedolla, Hyung-Sik Kang, Tomoyuki Nishizaki, Alessandra Larini, Shu-Feng Zhou, Jin-Jun Zhang, Geert Meyfroidt, Kisung Ko, Kerstin Seidel, Daniel Godínez-Hernández, Hyun Soo Kwak, Lorenzo Ricci, Luisa Lucas, Victoria C. Cogger, Héctor Urquiza-Marín, Yasumasa Ikeda, Yoshitaka Kihira, Gerald Zernig, Shuhei Tomita, Shoko Fujii, Sarah N. Hilmer, Ming Wei, Haeng-A. Kang, Geert Maleux, Yuling Chen, Rafael de Cabo, Min Park, Beatrice Gorelli, Lai-Bao Sun, Kai K. Kummer, Takeshi Kanno, Xue-Nong Zou, Chris Verslype, Sarah Bernhard, Ki-Mo Lee, Blanca Nateras-Marín, José Antonio Reyes-Ramírez, Sabrina Klare, Toshiaki Tamaki, Akinobu Gotoh, Brett Jones, Janine M. Prast, Hwa-Youn Lee, Eva Schrezenmeier, Christian Böhm, Wan Kyunn Whang, Takumi Sakurada, Shuichi Hamano, Jong Mi Lee, Yuki Izawa-Ishizawa, Isabel Spriet, Aniko Huizer-Pajkos, Chung Hyo Kim, David G. Le Couteur, Massimo Valoti, Sebastian Kirsch, C. Jandrisits, Petra Goldin-Lang, Andrew J. McLachlan, Druck Reinhardt Druck Basel, Uy Dong Sohn, Thao Thanh Nguyen, Sun Young Park, Xian-Guo Liu, Lijun Cao, Neel R. Nabar, Melanie Kroh, Qiu-Lan He, Werner Skuballa, Hisao Nagaya, Frank S. Zollmann, Lixiang Wu, Hironori Taira, Thomas Unger, Kristin Schmerbach
Publikováno v:
Pharmacology. 90:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f47e12278c97a01fd01afb1a24b16c0
https://doi.org/10.1159/000345034
https://doi.org/10.1159/000345034
Autor:
Thomas Unger, Frank S. Zollmann, Christa Thöne-Reineke, Jennifer Schmitz, Heiko Funke-Kaiser, Sebastian Kirsch, Daniela Zaade, Kristin Lucht, Jan H. Schefe, Petra Goldin-Lang, Yaosi Li, Kerstin Seidel, Kristin Schmerbach, Jana Reinemund, Sabrina Klare
Publikováno v:
Brain Pathology. 21:31-43
Stroke is one of the major medical burdens in industrialized countries. Animal experiments indicate that blockade of the angiotensin AT1 receptor (AT1R) improves neurological outcome after cerebral ischemia. These protective effects are partially med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37c37ef5b6e1bd9eda09fce94285ae86
https://doi.org/10.1111/j.1750-3639.2010.00427.x
https://doi.org/10.1111/j.1750-3639.2010.00427.x
Autor:
Sebastian Kirsch, Kerstin Seidel, Ulrike Muscha Steckelings, Thomas Unger, Marco Sifringer, Claudia Spies, Jan H. Schefe, Clarissa von Haefen, Jana Reinemund, Heiko Funke-Kaiser, Mario Menk
Publikováno v:
Alcohol. 44:495-506
Molecular mechanisms accompanying ethanol-induced cytotoxicity remain to be defined. The renin–angiotensin system with its respective receptors, the angiotensin AT1 and AT2 receptor (AT1R and AT2R), has been implicated in these processes. The AT2R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b9b10deb266a3d8b54de892945c5a8
https://doi.org/10.1016/j.alcohol.2010.05.005
https://doi.org/10.1016/j.alcohol.2010.05.005
Autor:
Katja Ströder, Anne Reichenbach, Torsten Zuberbier, Jens Schacherl, Metin Artuc, Anders Hallberg, Michael Bader, Natalia Alenina, U. Muscha Steckelings, Franziska Rompe, Heiko Funke-Kaiser, Thomas Unger, Christa Thöne-Reineke, Wolf-Hagen Schunck, Markus Schwaninger, Mathias Alterman, Björn Dahlöf, Cosima Schmidt
Publikováno v:
Hypertension. 55:924-931
Angiotensin II type 2 (AT 2 ) receptors can be regarded as an endogenous repair system, because the AT 2 receptor is upregulated in tissue damage and mediates tissue protection. A potential therapeutic use of this system has only recently come within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b121e043650dd055b13b9a91762a55
https://doi.org/10.1161/hypertensionaha.109.147843
https://doi.org/10.1161/hypertensionaha.109.147843
Autor:
Gabor Olah, Yaosi Li, Jan H. Schefe, Jens Schacherl, Petra Goldin-Lang, Kerstin Seidel, Ulrike Muscha Steckelings, Daniela Zaade, Thomas Unger, Marlen Katerbaum, Mario Menk, Csaba Szabó, Heiko Funke-Kaiser, Franziska Rompe, Sabrina Klare, Jana Reinemund
Publikováno v:
Biochemical Pharmacology. 77:1795-1805
The renin-angiotensin system (RAS) plays a crucial role in cardiovascular and neuronal (patho-)physiology. The angiotensin AT2 receptor (AT2R) seems to counteract the proinflammatory, prohypertrophic and profibrotic actions of the AT1 receptor. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e86bca059a7566626ed852e88df6aa
https://doi.org/10.1016/j.bcp.2009.02.025
https://doi.org/10.1016/j.bcp.2009.02.025
Autor:
Maxim Krikov, Christian Neumann, Heide Hörtnagl, Heiko Funke-Kaiser, Arno Villringer, Ulrike Muscha Steckelings, Kay Rumschüssel, Kristin Lucht, Christa Thöne-Reineke, Kristin Schmerbach, Michael Godes, Jan H. Schefe, Pawel Namsolleck, Thomas Unger, Susanne Müller
Publikováno v:
Journal of Hypertension. 26:2426-2435
Ceftriaxone has been reported to reduce neuronal damage in amyotrophic lateral sclerosis and in an in-vitro model of neuronal ischaemia through increased expression and activity of the glutamate transporter, GLT1. We tested the effects of ceftriaxone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3351f4ff7a14ad1575f21c38511b0d
https://doi.org/10.1097/hjh.0b013e328313e403
https://doi.org/10.1097/hjh.0b013e328313e403
Autor:
Michael Godes, Heiko Funke-Kaiser, Christian Bauer, Franz Theuring, Fred Schmager, Torsten Slowinski, Philipp Kalk, Hans-H. Neumayer, Maren Christian, Katharina Relle, Berthold Hocher
Publikováno v:
The Journal of Physiology. 581:1173-1181
Nitric oxide (NO) and endothelin-1 (ET-1) are known to play a major role in renal and vascular pathophysiology and exhibit a close interaction with ET-1, stimulating NO production; NO in turn inhibits ET-1 expression. Our objectives were (1) to estab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eec4d6db59a9de24060da8c4076d6fe4
https://doi.org/10.1113/jphysiol.2007.131201
https://doi.org/10.1113/jphysiol.2007.131201