Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Heiko van der Kuip"'
Autor:
Elisabeth Silkenstedt, Fabian Arenas, Berta Colom-Sanmartí, Sílvia Xargay-Torrent, Morihiro Higashi, Ariadna Giró, Vanina Rodriguez, Patricia Fuentes, Walter E. Aulitzky, Heiko van der Kuip, Sílvia Beà, Maria L. Toribio, Elias Campo, Mònica López-Guerra, Dolors Colomer
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-15 (2019)
Abstract Background NOTCH1 gene mutations in mantle cell lymphoma (MCL) have been described in about 5–10% of cases and are associated with significantly shorter survival rates. The present study aimed to investigate the biological impact of this m
Externí odkaz:
https://doaj.org/article/c4021314106c4f4abaaa90f1fc1bd397
Autor:
Simon Heine, Markus Kleih, Neus Giménez, Kathrin Böpple, German Ott, Dolors Colomer, Walter E. Aulitzky, Heiko van der Kuip, Elisabeth Silkenstedt
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-15 (2018)
Abstract Background Mantle cell lymphoma (MCL) is an aggressive B-non-Hodgkin lymphoma with generally poor outcome. MCL is characterized by an aberrantly high cyclin D1-driven CDK4 activity. New molecular targeted therapies such as inhibitors of the
Externí odkaz:
https://doaj.org/article/3cf96957d1a94c81904cebab6bed8b4c
Autor:
Matthias Schwab, Hermann Koepsell, Peter Ruth, Alex Sparreboom, Sharyn D. Baker, Shuiying Hu, Christopher Volk, Ute Hofmann, Christiane Pott, Michael Kneba, Oliver Bruhn, Ingolf Cascorbi, Heiko van der Kuip, Elke Schaeffeler, Anne T. Nies
Purpose: In addition to mutated BCR-ABL1 kinase, the organic cation transporter 1 (OCT1, encoded by SLC22A1) has been considered to contribute to imatinib resistance in patients with chronic myeloid leukemia (CML). As data are conflicting as to wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f013ab972a14940aac20631fbfb3ac1
https://doi.org/10.1158/1078-0432.c.6521798
https://doi.org/10.1158/1078-0432.c.6521798
Autor:
Matthias Schwab, Hermann Koepsell, Peter Ruth, Alex Sparreboom, Sharyn D. Baker, Shuiying Hu, Christopher Volk, Ute Hofmann, Christiane Pott, Michael Kneba, Oliver Bruhn, Ingolf Cascorbi, Heiko van der Kuip, Elke Schaeffeler, Anne T. Nies
PDF file 64K, Supplementary Table S1. Overview of conflicting reports regarding the importance of OCT1 genetics, OCT1 expression, or cellular imatinib uptake for imatinib pharmacokinetics and response Supplementary Table S2. Multiple reaction monitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39014950324b9677b03c2a633b7f03c
https://doi.org/10.1158/1078-0432.22449920
https://doi.org/10.1158/1078-0432.22449920
Autor:
Matthias Schwab, Hermann Koepsell, Peter Ruth, Alex Sparreboom, Sharyn D. Baker, Shuiying Hu, Christopher Volk, Ute Hofmann, Christiane Pott, Michael Kneba, Oliver Bruhn, Ingolf Cascorbi, Heiko van der Kuip, Elke Schaeffeler, Anne T. Nies
PDF file 79K, Supplementary Figure S1: Uptake of imatinib and OCT1 probe substrate TEA into OCT1-expressing cells and vector-transfected control cells Supplementary Figure S2: Cellular uptake of the OCT1 probe substrate TEA and imatinib into mOct1- o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab1355ca4c97d48ce0e9c9e5c5c8591
https://doi.org/10.1158/1078-0432.22449926
https://doi.org/10.1158/1078-0432.22449926
Autor:
Matthias Schwab, Hermann Koepsell, Peter Ruth, Alex Sparreboom, Sharyn D. Baker, Shuiying Hu, Christopher Volk, Ute Hofmann, Christiane Pott, Michael Kneba, Oliver Bruhn, Ingolf Cascorbi, Heiko van der Kuip, Elke Schaeffeler, Anne T. Nies
PDF file 65K, Supplementary methods including chemicals, generation of a cell line expressing OCT1 variant p.V408, transport studies using oocytes and cell lines, LC-MS-MS analysis of imatinib, RNA isolation and quantification, shRNA knockdown, flow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac52f13b4d4f93c4411c3b506aa83ffc
https://doi.org/10.1158/1078-0432.22449923
https://doi.org/10.1158/1078-0432.22449923
Autor:
Heiko van der Kuip, Walter E. Aulitzky, Georg Sauer, Jens O. Schmid, Thomas E. Mürdter, Simon Heine, Christoph Ulmer, Matthias Schwab, Lea Schaaf
Although hyperthermia offers clinical appeal to sensitize cells to chemotherapy, this approach has been limited in terms of long-term outcome as well as economic and technical burden. Thus, a more detailed knowledge about how hyperthermia exerts its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f05276d2417a1ede94674951706699e
https://doi.org/10.1158/0008-5472.c.6507675
https://doi.org/10.1158/0008-5472.c.6507675
Autor:
Heiko van der Kuip, Walter E. Aulitzky, Moshe Oren, Stephan Kruck, Jens Bedke, Michael A. Dengler, Andrea Weilbacher, Thomas Mueller, Matthias Gutekunst
PDF file - 15K, Noxa, Puma and Bim are not cross-regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bd71b2a56e7e3d9f3f52a48763ba60
https://doi.org/10.1158/0008-5472.22398950
https://doi.org/10.1158/0008-5472.22398950
Autor:
Heiko van der Kuip, Walter E. Aulitzky, Moshe Oren, Stephan Kruck, Jens Bedke, Michael A. Dengler, Andrea Weilbacher, Thomas Mueller, Matthias Gutekunst
PDF file - 39K, Nutlin-3 sensitivity is correlated with Oct-4 and Noxa protein levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490cd765ce1eabd3f7da6ce1df656899
https://doi.org/10.1158/0008-5472.22398941.v1
https://doi.org/10.1158/0008-5472.22398941.v1
Autor:
Heiko van der Kuip, Walter E. Aulitzky, Moshe Oren, Thomas E. Mürdter, German Ott, Andreas Grabner, Sabine Bode, Godehard Friedel, Silke Haubeiss, Meng Dong, Jens O. Schmid
PDF file - 86K, Patient characteristics and treatment regimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c295f2ecb528c0d1c0672faff9f4a17
https://doi.org/10.1158/0008-5472.22395182
https://doi.org/10.1158/0008-5472.22395182