Zobrazeno 1 - 10
of 352
pro vyhledávání: '"Heikki Ruskoaho"'
Autor:
Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently needed. Human induced
Externí odkaz:
https://doaj.org/article/e9849cfeb7e34860b937a7a7a18376a5
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAfter birth, mammalian cardiomyocytes substantially lose proliferative capacity with a concomitant switch from glycolytic to oxidative mitochondrial energy metabolism. Micro-RNAs (miRNAs) regulate gene expression and thus control various ce
Externí odkaz:
https://doaj.org/article/520f1e19c9654d1d87cde56cc0f41872
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 2, Iss , Pp 100020- (2022)
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular myocytes (NRVMs)
Externí odkaz:
https://doaj.org/article/fc2a6429601c4ef69f9f2a67e6504b33
Autor:
Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak, Heikki Ruskoaho
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could overcome non-specific
Externí odkaz:
https://doaj.org/article/614c3e9ddc044f04a27581297b6207ab
Autor:
Celine Fernandez, Jaana Rysä, Kristoffer Ström, Jan Nilsson, Gunnar Engström, Marju Orho‐Melander, Heikki Ruskoaho, Olle Melander
Publikováno v:
ESC Heart Failure, Vol 7, Iss 4, Pp 1891-1899 (2020)
Abstract Aims Hypertension is the leading cause for the development of heart failure (HF). Here, we aimed to identify cardiomyocyte stretch‐induced circulating biomarkers for predicting hypertension‐associated HF. Methods and results Circulating
Externí odkaz:
https://doaj.org/article/97a4005d990640c5b69a195fb1da0f3d
Autor:
Jonna Weisell, Pauli Ohukainen, Juha Näpänkangas, Steffen Ohlmeier, Ulrich Bergmann, Tuomas Peltonen, Panu Taskinen, Heikki Ruskoaho, Jaana Rysä
Publikováno v:
BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Calcific aortic valve disease (CAVD) is an atheroinflammatory process; finally it leads to progressive calcification of the valve. There is no effective pharmacological treatment for CAVD and many of the underlying molecular mecha
Externí odkaz:
https://doaj.org/article/89288b4c82b24f9b91558eb2b2448f6f
Autor:
Laura E. Vainio, MD, Zoltán Szabó, MSc, Ruizhu Lin, MSc, Johanna Ulvila, PhD, Raisa Yrjölä, MSc, Tarja Alakoski, MSc, Jarkko Piuhola, MD, PhD, Walter J. Koch, PhD, Heikki Ruskoaho, MD, PhD, Shaun D. Fouse, PhD, Todd W. Seeley, PhD, Erhe Gao, MD, PhD, Pierre Signore, PhD, Kenneth E. Lipson, PhD, Johanna Magga, PhD, Risto Kerkelä, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 1, Pp 83-94 (2019)
Summary: Myocardial infarction (MI)−induced cardiac fibrosis attenuates cardiac contractile function, and predisposes to arrhythmias and sudden cardiac death. Expression of connective tissue growth factor (CTGF) is elevated in affected organs in vi
Externí odkaz:
https://doaj.org/article/a4c614fa5d9249b080d2fe33ba0c0e4d
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure. A key signaling molecu
Externí odkaz:
https://doaj.org/article/3d32b0334d36473a86f18126267d3d4d
Autor:
Virpi Talman, Jaakko Teppo, Päivi Pöhö, Parisa Movahedi, Anu Vaikkinen, S. Tuuli Karhu, Kajetan Trošt, Tommi Suvitaival, Jukka Heikkonen, Tapio Pahikkala, Tapio Kotiaho, Risto Kostiainen, Markku Varjosalo, Heikki Ruskoaho
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 20 (2018)
Background The molecular mechanisms mediating postnatal loss of cardiac regeneration in mammals are not fully understood. We aimed to provide an integrated resource of mRNA, protein, and metabolite changes in the neonatal heart for identification of
Externí odkaz:
https://doaj.org/article/9482c6aaa55e4ff6836035f853b4f626
Autor:
Suneeta Narumanchi, Karri Kalervo, Sanni Perttunen, Hong Wang, Katariina Immonen, Riikka Kosonen, Mika Laine, Heikki Ruskoaho, Ilkka Tikkanen, Päivi Lakkisto, Jere Paavola
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 6, Iss 2, p 16 (2019)
The let-7c family of micro-RNAs (miRNAs) is expressed during embryonic development and plays an important role in cell differentiation. We have investigated the role of let-7c in heart regeneration after injury in adult zebrafish. let-7c antagomir or
Externí odkaz:
https://doaj.org/article/03a5300173ba40ca90af18e329051abc