Zobrazeno 1 - 10
of 352
pro vyhledávání: '"Heikki, Ruskoaho"'
Autor:
Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently needed. Human induced
Externí odkaz:
https://doaj.org/article/e9849cfeb7e34860b937a7a7a18376a5
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAfter birth, mammalian cardiomyocytes substantially lose proliferative capacity with a concomitant switch from glycolytic to oxidative mitochondrial energy metabolism. Micro-RNAs (miRNAs) regulate gene expression and thus control various ce
Externí odkaz:
https://doaj.org/article/520f1e19c9654d1d87cde56cc0f41872
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 2, Iss , Pp 100020- (2022)
Left ventricular hypertrophy, characterized by hypertrophy of individual cardiomyocytes, is an adaptive response to an increased cardiac workload that eventually leads to heart failure. Previous studies using neonatal rat ventricular myocytes (NRVMs)
Externí odkaz:
https://doaj.org/article/fc2a6429601c4ef69f9f2a67e6504b33
Autor:
Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak, Heikki Ruskoaho
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could overcome non-specific
Externí odkaz:
https://doaj.org/article/614c3e9ddc044f04a27581297b6207ab
Autor:
Celine Fernandez, Jaana Rysä, Kristoffer Ström, Jan Nilsson, Gunnar Engström, Marju Orho‐Melander, Heikki Ruskoaho, Olle Melander
Publikováno v:
ESC Heart Failure, Vol 7, Iss 4, Pp 1891-1899 (2020)
Abstract Aims Hypertension is the leading cause for the development of heart failure (HF). Here, we aimed to identify cardiomyocyte stretch‐induced circulating biomarkers for predicting hypertension‐associated HF. Methods and results Circulating
Externí odkaz:
https://doaj.org/article/97a4005d990640c5b69a195fb1da0f3d
Autor:
Jonna Weisell, Pauli Ohukainen, Juha Näpänkangas, Steffen Ohlmeier, Ulrich Bergmann, Tuomas Peltonen, Panu Taskinen, Heikki Ruskoaho, Jaana Rysä
Publikováno v:
BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Calcific aortic valve disease (CAVD) is an atheroinflammatory process; finally it leads to progressive calcification of the valve. There is no effective pharmacological treatment for CAVD and many of the underlying molecular mecha
Externí odkaz:
https://doaj.org/article/89288b4c82b24f9b91558eb2b2448f6f
Autor:
Laura E. Vainio, MD, Zoltán Szabó, MSc, Ruizhu Lin, MSc, Johanna Ulvila, PhD, Raisa Yrjölä, MSc, Tarja Alakoski, MSc, Jarkko Piuhola, MD, PhD, Walter J. Koch, PhD, Heikki Ruskoaho, MD, PhD, Shaun D. Fouse, PhD, Todd W. Seeley, PhD, Erhe Gao, MD, PhD, Pierre Signore, PhD, Kenneth E. Lipson, PhD, Johanna Magga, PhD, Risto Kerkelä, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 1, Pp 83-94 (2019)
Summary: Myocardial infarction (MI)−induced cardiac fibrosis attenuates cardiac contractile function, and predisposes to arrhythmias and sudden cardiac death. Expression of connective tissue growth factor (CTGF) is elevated in affected organs in vi
Externí odkaz:
https://doaj.org/article/a4c614fa5d9249b080d2fe33ba0c0e4d
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure. A key signaling molecu
Externí odkaz:
https://doaj.org/article/3d32b0334d36473a86f18126267d3d4d
Autor:
Giulia Torrieri, Imran Iqbal, Flavia Fontana, Virpi Talman, Heidi Liljenbäck, Andriana Putri, Wail Nammas, Johan Rajander, Xiang Guo‐Li, Philip S. Low, Tambet Teesalu, Anne Roivainen, Jouni Hirvonen, Heikki Ruskoaho, Vimalkumar Balasubramanian, Antti Saraste, Hélder A. Santos
Publikováno v:
Advanced Functional Materials, n/a(n/a):2303658. WILEY-V C H VERLAG GMBH
Myocardial infarction (MI) is the leading cause of death worldwide. However, current therapies are unable to restore the function of the injured myocardium. Advanced approaches, such as stimulation of cardiomyocyte (CM) proliferation are promising, b
Autor:
Anni Suominen, Guillem Saldo Rubio, Saku Ruohonen, Zoltán Szabó, Lotta Pohjolainen, Bishwa Ghimire, Suvi T. Ruohonen, Karla Saukkonen, Jani Ijas, Sini Skarp, Leena Kaikkonen, Minying Cai, Sharon L. Wardlaw, Heikki Ruskoaho, Virpi Talman, Eriika Savontaus, Risto Kerkelä, Petteri Rinne
Backgroundα-Melanocyte-stimulating hormone (α-MSH) regulates diverse physiological functions by activating melanocortin receptors (MC-R). α-MSH is predominantly expressed in the pituitary gland, but it is also found in several peripheral tissues s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30016c0bf2a37facb0826939534ff5cf
https://doi.org/10.1101/2023.04.06.535956
https://doi.org/10.1101/2023.04.06.535956