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pro vyhledávání: '"Heiker, John T"'
Autor:
Tindall, Catherine A., Möhlis, Kevin, Rapöhn, Inka, Dommel, Sebastian, Riedl, Veronika, Schneekönig, Michael, Höfling, Corinna, Roßner, Steffen, Stichel, Jan, Beck-Sickinger, Annette G., Weiner, Juliane, Heiker, John T.
Vaspin is a serine protease inhibitor that protects against adipose tissueinflammation and insulin resistance, two key drivers of adipocyte dysfunc-tion and metabolic disorders in obesity. Inhibition of target proteases suchas KLK7 has been shown to
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A94162
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https://ul.qucosa.de/api/qucosa%3A94162/attachment/ATT-0/
Visceral adipose tissue derived serine protease inhibitor (vaspin) or SERPINA12 according to the serpin nomenclature was identified together with other genes and gene products that were specifically expressed or overexpressed in the intra abdominal o
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A38022
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https://ul.qucosa.de/api/qucosa%3A38022/attachment/ATT-0/
Autor:
Zieger, Konstanze, Weiner, Juliane, Krause, Kerstin, Schwarz, Maximilian, Kohn, Martin, Stumvoll, Michael, Blüher, Matthias, Heiker, John T.
Vaspin expression is increased in white adipose tissue (WAT) of diet-induced obese mice and rats and is supposed to compensate HFD-induced inflammatory processes and insulin resistance in adipose tissue by counteracting pro-inflammatory gene expressi
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A33206
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https://ul.qucosa.de/api/qucosa%3A33206/attachment/ATT-0/
Autor:
Ulbricht, David, Tindall, Catherine A., Oertwig, Kathrin, Hanke, Stefanie, Sträter, Norbert, Heiker, John T.
Kallikrein-related peptidases KLK5, KLK7 and KLK14 are important proteases in skin desquamation and aberrant KLK activity is associated with inflammatory skin diseases such as Netherton syndrome but also with various serious forms of cancer. Previous
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A38021
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https://ul.qucosa.de/api/qucosa%3A38021/attachment/ATT-0/
Autor:
Zieger, Konstanze, Weiner, Juliane, Kunath, Anne, Gericke, Martin, Krause, Kerstin, Kern, Matthias, Stumvoll, Michael, Klöting, Nora, Blüher, Matthias, Heiker, John T.
Vaspin is an adipokine which improves glucose metabolism and insulin sensitivity in obesity. Kallikrein 7 (KLK7) is the first known protease target inhibited by vaspin and a potential target for the treatment of metabolic disorders. Here, we tested t
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A33207
https://ul.qucosa.de/api/qucosa%3A33207/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A33207/attachment/ATT-0/
Autor:
Ulbricht, David, Oertwig, Kathrin, Arnsburg, Kristin, Saalbach, Anja, Pippel, Jan, Sträter, Norbert, Heiker, John T.
Many members of the serine protease inhibitor (serpin) family are activated by glycosaminoglycans (GAGs). Visceral adipose tissue-derived serpin (vaspin), serpin A12 of the serpin family, and its target protease kallikrein 7 (KLK7) are heparin-bindin
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A33433
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https://ul.qucosa.de/api/qucosa%3A33433/attachment/ATT-0/
Autor:
Oertwig, Kathrin, Ulbricht, David, Hanke, Stefanie, Pippel, Jan, Bellmann-Sickert, Kathrin, Sträter, Norbert, Heiker, John T.
Vaspin is a glycoprotein with three predicted glycosylation sites at asparagine residues located in proximity to the reactive center loop and close to domains that play important roles in conformational changes underlying serpin function. In this stu
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A33428
https://ul.qucosa.de/api/qucosa%3A33428/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A33428/attachment/ATT-0/
Autor:
Pippel, Jan, Kuettner, E. Bartholomeus, Ulbricht, David, Daberger, Jan, Schultz, Stephan, Heiker, John T., Sträter, Norbert
The adipokine vaspin (serpinA12) is mainly expressed in white adipose tissue and exhibits various beneficial effects on obesity-related processes. Kallikrein 7 is the only known target protease of vaspin and is inhibited by the classical serpin inhib
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A33438
https://ul.qucosa.de/api/qucosa%3A33438/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A33438/attachment/ATT-0/
Autor:
Mardinoglu, Adil, Heiker, John T., Gärtner, Daniel, Björnson, Elias, Schön, Michael R., Flehmig, Gesine, Klöting, Nora, Krohn, Knut, Fasshauer, Mathias, Stumvoll, Michael, Nielsen, Jens, Blüher, Matthias
Publikováno v:
Scientific reports 2015, 5:14841
Weight loss has been shown to significantly improve Adipose tissue (AT) function, however changes in AT gene expression profiles particularly in visceral AT (VAT) have not been systematically studied. Here, we tested the hypothesis that extensive wei
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A13938
https://ul.qucosa.de/api/qucosa%3A13938/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A13938/attachment/ATT-0/
Autor:
Ulbricht, David, Pippel, Jan, Schultz, Stephan, Meier, René, Sträter, Norbert, Heiker, John T.
SerpinA12 (vaspin) is thought to be mainly expressed in adipose tissue and has multiple beneficial effects on metabolic, inflammatory and atherogenic processes related to obesity. KLK7 (kallikrein 7) is the only known protease target of vaspin to dat
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A33439
https://ul.qucosa.de/api/qucosa%3A33439/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A33439/attachment/ATT-0/