Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Heike Weidner"'
Autor:
Maria G. Ledesma-Colunga, Ulrike Baschant, Heike Weidner, Tiago C. Alves, Peter Mirtschink, Lorenz C. Hofbauer, Martina Rauner
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102616- (2023)
Objective: Rheumatoid arthritis is an inflammatory joint disease in which synovial iron deposition has been described. Transferrin receptor 2 (Tfr2) represents a critical regulator of systemic iron levels. Loss of Tfr2 function in humans and mice res
Externí odkaz:
https://doaj.org/article/b6dfec1e6fe644efb74ea14a924671ec
Autor:
Maik Herbig, Angela Jacobi, Manja Wobus, Heike Weidner, Anna Mies, Martin Kräter, Oliver Otto, Christian Thiede, Marie‑Theresa Weickert, Katharina S. Götze, Martina Rauner, Lorenz C. Hofbauer, Martin Bornhäuser, Jochen Guck, Marius Ader, Uwe Platzbecker, Ekaterina Balaian
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Diagnosis of myelodysplastic syndrome (MDS) mainly relies on a manual assessment of the peripheral blood and bone marrow cell morphology. The WHO guidelines suggest a visual screening of 200 to 500 cells which inevitably turns the assessor b
Externí odkaz:
https://doaj.org/article/47750a67f89b4072ae8b903f4aa9907e
Autor:
Franziska Hettler, Christina Schreck, Sandra Romero Marquez, Thomas Engleitner, Baiba Vilne, Theresa Landspersky, Heike Weidner, Renate Hausinger, Ritu Mishra, Rupert Oellinger, Martina Rauner, Ronald Naumann, Christian Peschel, Florian Bassermann, Roland Rad, Rouzanna Istvanffy, Robert A.J. Oostendorp
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Remodeling of the bone marrow microenvironment in chronic inflammation and in aging reduces hematopoietic stem cell (HSC) function. To assess the mechanisms of this functional decline of HSC and find strategies to counteract it, we established a mode
Externí odkaz:
https://doaj.org/article/942464b251af43739fad8007d14f664c
Autor:
Sylvia Thiele, Anke Hannemann, Maria Winzer, Ulrike Baschant, Heike Weidner, Matthias Nauck, Rajesh V Thakker, Martin Bornhäuser, Lorenz C Hofbauer, Martina Rauner
Publikováno v:
Endocrine Connections, Vol 8, Iss 7, Pp 923-934 (2019)
Glucocorticoids (GC) are used for the treatment of inflammatory diseases, including various forms of arthritis. However, their use is limited, amongst others, by adverse effects on bone. The Wnt and bone formation inhibitor sclerostin was recently im
Externí odkaz:
https://doaj.org/article/859dcd8053174ff2af1c895a18d3602b
Autor:
Ekaterina Balaian, Manja Wobus, Heike Weidner, Ulrike Baschant, Maik Stiehler, Gerhard Ehninger, Martin Bornhäuser, Lorenz C Hofbauer, Martina Rauner, Uwe Platzbecker
Publikováno v:
Haematologica, Vol 103, Iss 1 (2018)
The effects of erythropoietin on osteoblasts and bone formation are controversial. Since patients with myelodysplastic syndromes often display excessively high erythropoietin levels, we aimed to analyze the effect of erythropoietin on osteoblast func
Externí odkaz:
https://doaj.org/article/4f60909befcc42e0819da8e4d84639d8
Autor:
Ulrike Baschant, Martina Rauner, Ekaterina Balaian, Heike Weidner, Antonella Roetto, Uwe Platzbecker, Lorenz C. Hofbauer
Publikováno v:
Haematologica, Vol 101, Iss 12 (2016)
Iron overload due to hemochromatosis or chronic blood transfusions has been associated with the development of osteoporosis. However, the impact of changes in iron homeostasis on osteoblast functions and the underlying mechanisms are poorly defined.
Externí odkaz:
https://doaj.org/article/a51eb38aa34b44e89d5d02bda0ba34bb
Luspatercept mitigates bone loss driven by myelodysplastic neoplasms and estrogen-deficiency in mice
Publikováno v:
Leukemia. 36:2715-2718
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdeb02420b4bdd1a0e26db94a3755d6c
https://doi.org/10.1038/s41375-022-01702-1
https://doi.org/10.1038/s41375-022-01702-1
Autor:
Martina Rauner, Lorenz C. Hofbauer, Ulrike Baschant, Heike Weidner, Maria G. Ledesma-Colunga, Maja Vujic Spasic
Publikováno v:
Seminars in Hematology. 58:188-200
Well-controlled iron levels are indispensable for health. Iron deficiency is the most common cause of anemia, whereas iron overload, either hereditary or secondary due to disorders of ineffective erythropoiesis, causes widespread organ failure. Bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3867148fb9ffcc7f5b09bdc37fdd448b
https://doi.org/10.1053/j.seminhematol.2021.06.002
https://doi.org/10.1053/j.seminhematol.2021.06.002
Autor:
Martina Rauner, Susann Winter, Uwe Platzbecker, Kristin Möbus, Lorenz C. Hofbauer, Heike Weidner, Michael Cross, Uta Oelschlägel, Nandini Asokan, Anna Mies, Martin Bornhäuser, Manja Wobus
Publikováno v:
Leukemia
The bone marrow microenvironment (BMME) plays a key role in the pathophysiology of myelodysplastic syndromes (MDS), clonal blood disorders affecting the differentiation, and maturation of hematopoietic stem and progenitor cells (HSPCs). In lower-risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3d2b9be0f45d1872a75b63dbdc2d67
http://europepmc.org/articles/PMC8478655
http://europepmc.org/articles/PMC8478655
Autor:
Luise Hartmann, Judith S. Hecker, Maja Rothenberg-Thurley, Jennifer Rivière, Madlen Jentzsch, Bianka Ksienzyk, Michèle C. Buck, Mark van der Garde, Luise Fischer, Susann Winter, Martina Rauner, Elena Tsourdi, Heike Weidner, Katja Sockel, Marie Schneider, Anne S. Kubasch, Martin Nolde, Dominikus Hausmann, Jörg Lützner, Szymon Goralski, Florian Bassermann, Karsten Spiekermann, Lorenz C. Hofbauer, Sebastian Schwind, Uwe Platzbecker, Katharina S. Götze, Klaus H. Metzeler
Publikováno v:
Leukemia. 36(11)
Clonal hematopoiesis (CH) is characterized by somatic mutations in blood cells of individuals without hematologic disease. While the mutational landscape of CH in peripheral blood (PB) has been well characterized, detailed analyses addressing its spa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b115b8bd10b4a5f6c72addf61a95075
https://pubmed.ncbi.nlm.nih.gov/36131041
https://pubmed.ncbi.nlm.nih.gov/36131041