Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Heike Stephanowitz"'
Autor:
Carola Mancini, Sabrina Gohlke, Francisco Garcia-Carrizo, Vyacheslav Zagoriy, Heike Stephanowitz, Tim J. Schulz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Brown adipose tissue function declines during aging and may contribute to the onset of metabolic disorders such as diabetes and obesity. Only limited understanding of the mechanisms leading to the metabolic impairment of brown adipocytes dur
Externí odkaz:
https://doaj.org/article/cf9ff986f53a492da2a296b62f9b012a
Autor:
Sabrina Gohlke, Vyacheslav Zagoriy, Alvaro Cuadros Inostroza, Michaël Méret, Carola Mancini, Lukasz Japtok, Fabian Schumacher, Doreen Kuhlow, Antonia Graja, Heike Stephanowitz, Markus Jähnert, Eberhard Krause, Andreas Wernitz, Klaus-Jürgen Petzke, Annette Schürmann, Burkhard Kleuser, Tim J. Schulz
Publikováno v:
Molecular Metabolism, Vol 24, Iss , Pp 1-17 (2019)
Objective: Aging is accompanied by loss of brown adipocytes and a decline in their thermogenic potential, which may exacerbate the development of adiposity and other metabolic disorders. Presently, only limited evidence exists describing the molecula
Externí odkaz:
https://doaj.org/article/7f7c83198cd742eb89c1dd8e58c9e6c9
Autor:
Selvaraj Pavulraj, Mohamed Kamel, Heike Stephanowitz, Fan Liu, Johanna Plendl, Nikolaus Osterrieder, Walid Azab
Publikováno v:
Viruses, Vol 12, Iss 9, p 999 (2020)
Equine herpesvirus type 1 (EHV-1) causes encephalomyelopathy and abortion, for which cell-associated viremia and subsequent virus transfer to and replication in endothelial cells (EC) are responsible and prerequisites. Viral and cellular molecules re
Externí odkaz:
https://doaj.org/article/5db6cd0bd57b4b2c8080fb3dc3a9cbe9
Autor:
Wen-Ting Lo, Yingyi Zhang, Oscar Vadas, Yvette Roske, Federico Gulluni, Maria Chiara De Santis, Andreja Vujicic Zagar, Heike Stephanowitz, Emilio Hirsch, Fan Liu, Oliver Daumke, Misha Kudryashev, Volker Haucke
Publikováno v:
Nature Structural & Molecular Biology. 29:218-228
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) is an essential member of the structurally unresolved class II PI3K family with crucial functions in lipid signaling, endocytosis, angiogenesis, viral replication, platelet formation and a role in mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb468cbbfe058190fe90d5ab6b4eeec
https://doi.org/10.1038/s41594-022-00730-w
https://doi.org/10.1038/s41594-022-00730-w
Publikováno v:
ACS macro letters. 8(6)
Peptides with suitable substrate properties for a specific tyrosinase are selected by combinatorial means from a one-bead-one-compound (OBOC) peptide library. The identified sequences exhibit tyrosine residues that are rapidly oxidized to 3,4-dihydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099092d5ecbe9fd1d591937ffbf2bd32
https://pubmed.ncbi.nlm.nih.gov/35619530
https://pubmed.ncbi.nlm.nih.gov/35619530
Autor:
Nirdosh Dadwal, Janine Degen, Jana Sticht, Tarek Hilal, Tatjana Wegner, Peter Reichardt, Ruth Lyck, Michael Abadier, Miroslav Hons, Charlie Mix, Benno Kuropka, Heike Stephanowitz, Fan Liu, Burkhart Schraven, Christoph Wülfing, Stefanie Kliche, Christian Freund
Intrinsically disordered proteins (IDPs) play a vital role in biological processes that rely on transient molecular compartmentation1. In T cells, the dynamic switching between migration and adhesion mandates a high degree of plasticity in the interp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e685d056ea1118570c86712f2f18e16
https://doi.org/10.1101/2021.12.14.472590
https://doi.org/10.1101/2021.12.14.472590
Autor:
Yaping Han, Jannis Schoppe, Heike Stephanowitz, Angela Perz, Amir Apelbaum, Oliver Hofnagel, Jacob Piehler, Fan Liu, Christian Ungermann, Stefan Raunser, Evelyn Schubert, Oliver Birkholz, Erdal Yavavli
Publikováno v:
The Journal of Biological Chemistry
Vesicle formation at endomembranes requires the selective concentration of cargo by coat proteins. Conserved adapter protein complexes at the Golgi (AP-3), the endosome (AP-1), or the plasma membrane (AP-2) with their conserved core domain and flexib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba2b369c182db77a3847ecec46c321c
https://pubmed.ncbi.nlm.nih.gov/34902351
https://pubmed.ncbi.nlm.nih.gov/34902351
Autor:
Becky Provinciael, Eberhard Krause, Claudia Rutz, Dominique Schols, Heike Stephanowitz, Joren Stroobants, Eva Pauwels, Enno Hartmann, Kurt Vermeire, Ralf Schülein
Publikováno v:
Molecular & Cellular Proteomics : MCP
Cyclotriazadisulfonamide (CADA) inhibits the cotranslational translocation of type I integral membrane protein human CD4 (huCD4) across the endoplasmic reticulum in a signal peptide (SP)–dependent way. Previously, sortilin was identified as a secon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fa4c29ffd398e3d63aa5ece3f08763
https://pubmed.ncbi.nlm.nih.gov/34481949
https://pubmed.ncbi.nlm.nih.gov/34481949
Autor:
Manuela Sommerfeld, Na Yang, Matthias Muenzner, Konstantin M. Petricek, Nicole Witte, Michael Schupp, Pamela Weber, Antti M. Salo, Till Schütte, Isabel Goehring, Anne Schumann, Steffi Heidenreich, Heike Stephanowitz, Moritz Oster, Johanna Myllyharju, Eberhard Krause, Miriam Knauer
Publikováno v:
J Biol Chem
Cellular energy demands are met by uptake and metabolism of nutrients like glucose. The principal transcriptional regulator for adapting glycolytic flux and downstream pathways like de novo lipogenesis to glucose availability in many cell types is ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a639b9db15d5bfcf6e25d36a7236e598
https://pubmed.ncbi.nlm.nih.gov/33023907
https://pubmed.ncbi.nlm.nih.gov/33023907
Publikováno v:
Macromolecular rapid communications. 41(1)
A previously introduced tyrosinase-activated polymerization of Tyr- and Cys-bearing peptides yielding artificial mussel-glue proteins is realized without the need of the specific enzyme by a chemical activation route. This decouples the sequence of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ae416c13b73e47b11f38e5519ff9ac
https://pubmed.ncbi.nlm.nih.gov/31692175
https://pubmed.ncbi.nlm.nih.gov/31692175