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pro vyhledávání: '"Heike S. Radeke"'
Autor:
Robinson Simon P, Heike S. Radeke, Kelley Hanson, Yu Ming, Ajay Purohit, Mikhail Kagan, Padmaja Yalamanchili, Fran Su, Michael Azure, Megan Hayes, Richard Benetti, David Casebier, Mary Guaraldi
Publikováno v:
Journal of Medicinal Chemistry. 51:2954-2970
A series of fluorinated pyridazinone derivatives with IC50 values ranging from 8 to 4000 nM for the mitochondrial complex 1 (MC1) have been prepared. Structure-activity relationship (SAR) assessment indicated preference of the fluorine label to be in