Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Heike S Grimm"'
Autor:
Marcus O W Grimm, Eva G Zinser, Sven Grösgen, Benjamin Hundsdörfer, Tatjana L Rothhaar, Verena K Burg, Lars Kaestner, Thomas A Bayer, Peter Lipp, Ulrike Müller, Heike S Grimm, Tobias Hartmann
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34095 (2012)
Gangliosides are important players for controlling neuronal function and are directly involved in AD pathology. They are among the most potent stimulators of Aβ production, are enriched in amyloid plaques and bind amyloid beta (Aβ). However, the mo
Externí odkaz:
https://doaj.org/article/97b810f1c3404c379a6fb004c8d572fb
Autor:
Anna A. Lauer, Vu Thu Thuy Nguyen, Daniel Janitschke, Malena dos Santos Guilherme, Cornel M. Bachmann, Heike S. Grimm, Tobias Hartmann, Kristina Endres, Marcus O. W. Grimm
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15535 (2022)
Administration of systemic retinoids such as acitretin has not been approved yet for pediatric patients. An adverse event of retinoid-therapy that occurs with lower prevalence in children than in adults is hyperlipidemia. This might be based on the l
Externí odkaz:
https://doaj.org/article/e7e71da85e334f808d1a5d3d439b1b67
Autor:
Daniel Janitschke, Anna A. Lauer, Cornel M. Bachmann, Heike S. Grimm, Tobias Hartmann, Marcus O. W. Grimm
Publikováno v:
Nutrients, Vol 13, Iss 3, p 803 (2021)
Methylxanthines (MTX) are purine derived xanthine derivatives. Whereas naturally occurring methylxanthines like caffeine, theophylline or theobromine are widely consumed in food, several synthetic but also non-synthetic methylxanthines are used as ph
Externí odkaz:
https://doaj.org/article/59b41af1fcd646dd9fe6fb5245d7997c
Autor:
Daniel Janitschke, Anna A. Lauer, Cornel M. Bachmann, Martin Seyfried, Heike S. Grimm, Tobias Hartmann, Marcus O. W. Grimm
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9015 (2020)
Methylxanthines are a group of substances derived from the purine base xanthine with a methyl group at the nitrogen on position 3 and different residues at the nitrogen on position 1 and 7. They are widely consumed in nutrition and used as pharmaceut
Externí odkaz:
https://doaj.org/article/f1b97c9f8e8e453aaae1fcc87bcc3a55
PS Dependent APP Cleavage Regulates Glucosylceramide Synthase and is Affected in Alzheimer's Disease
Autor:
Marcus O.W. Grimm, Benjamin Hundsdörfer, Sven Grösgen, Janine Mett, Valerie C. Zimmer, Christoph P. Stahlmann, Viola J. Haupenthal, Tatjana L. Rothhaar, Johannes Lehmann, Andreas Pätzold, Eva G. Zinser, Heikki Tanila, Jie Shen, Ulrike Müller, Heike S. Grimm, Tobias Hartmann
Publikováno v:
Cellular Physiology and Biochemistry, Vol 34, Iss 1, Pp 92-110 (2014)
Background: Gangliosides were found to be associated with Alzheimer's disease (AD). Here we addressed a potential function of γ-secretase (presenilin) dependent cleavage of the amyloid-precursor-protein (APP) in the regulation of ganglioside de novo
Externí odkaz:
https://doaj.org/article/a3e2c4e2b3bd4e48bda8229f2fdb0a8d
Autor:
Heike S. Grimm, Tobias Hartmann, Johannes Lehmann, Benjamin Hundsdörfer, Sven Grösgen, Valerie C. Zimmer, Tatjana L. Rothhaar, Viola J. Haupenthal, Marcus O. W. Grimm
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 3, Pp 5879-5898 (2013)
Alzheimer’s disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ec
Externí odkaz:
https://doaj.org/article/427f4cfb366f4035ac5a11123c7c8e72
Autor:
Tobias Hartmann, Elena Leoni Theiss, Teresa Giovanna Valencak, Anna A. Lauer, Jörg Reichrath, Christoph Beisswenger, Heike S. Grimm, Daniel Janitschke, Lea Victoria Griebsch, Robert Bals, Marcus Otto Walter Grimm, Dorothea Portius, Christian Herr, Sabrina Melanie Pilz
Publikováno v:
Biomolecules, Vol 11, Iss 1699, p 1699 (2021)
Biomolecules
Volume 11
Issue 11
Biomolecules
Volume 11
Issue 11
Vitamin D3 hypovitaminosis is associated with several neurological diseases such as Alzheimer’s disease, Parkinson’s disease or multiple sclerosis but also with other diseases such as cancer, diabetes or diseases linked to inflammatory processes.
Autor:
Marcus O. W. Grimm, Janine Mett, Anna A. Lauer, Heikki Tanila, Heike S. Grimm, Elena Leoni Theiss, Daniel Janitschke, Lea Victoria Griebsch, Tobias Hartmann, Hennariikka Koivisto
Publikováno v:
Cells; Volume 10; Issue 11; Pages: 2941
Cells
Cells, Vol 10, Iss 2941, p 2941 (2021)
Cells
Cells, Vol 10, Iss 2941, p 2941 (2021)
The accumulation of amyloid β-protein (Aβ) is one of the major pathological hallmarks of Alzheimer’s disease. Insulin-degrading enzyme (IDE), a zinc-metalloprotease, is a key enzyme involved in Aβ degradation, which, in addition to Aβ productio
Autor:
Anna A. Lauer, Heike S. Grimm, Daniel Janitschke, Tobias Hartmann, Marcus O. W. Grimm, Cornel M Bachmann
Publikováno v:
Nutrients
Nutrients, Vol 13, Iss 803, p 803 (2021)
Nutrients, Vol 13, Iss 803, p 803 (2021)
Methylxanthines (MTX) are purine derived xanthine derivatives. Whereas naturally occurring methylxanthines like caffeine, theophylline or theobromine are widely consumed in food, several synthetic but also non-synthetic methylxanthines are used as ph
Autor:
Janine Mett, Marcus O. W. Grimm, Anna A. Lauer, Matthias Riemenschneider, Heike S. Grimm, Ulrike Müller, Bianca Schrul, Christoph P Stahlmann, Tobias Hartmann, Cornel M Bachmann, Daniel Janitschke, Andrea Thiel, Felix Ritzmann, Reuven Stein
Publikováno v:
Aging Cell
One of the major pathological hallmarks of Alzheimer´s disease (AD) is an accumulation of amyloid‐β (Aβ) in brain tissue leading to formation of toxic oligomers and senile plaques. Under physiological conditions, a tightly balanced equilibrium b