Výsledky vyhledávání - "Heike Rübsamen"

Akademický článek

Intramuscular vaccination against SARS-CoV-2 transiently induces neutralizing IgG rather than IgA in the saliva

Autor: Stephan Winklmeier, Heike Rübsamen, Ceren Özdemir, Paul R. Wratil, Gaia Lupoli, Marcel Stern, Celine Schneider, Katharina Eisenhut, Samantha Ho, Hoi Kiu Wong, Damla Taskin, Marvin Petry, Michael Weigand, Peter Eichhorn, Bärbel U. Foesel, Simone Mader, Oliver T. Keppler, Tania Kümpfel, Edgar Meinl

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

The mucosal immunity is crucial for restricting SARS-CoV-2 at its entry site. Intramuscularly applied vaccines against SARS-CoV-2 stimulate high levels of neutralizing Abs in serum, but the impact of these intramuscular vaccinations on features of mu

Externí odkaz: https://doaj.org/article/9d42e7c5f3d24fc18847cc55adb70e1e

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Akademický článek

Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS

Publikováno v: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)

Abstract Autoimmune disorders of the central nervous system (CNS) comprise a broad spectrum of clinical entities. The stratification of patients based on the recognized autoantigen is of great importance for therapy optimization and for concepts of p

Externí odkaz: https://doaj.org/article/48e9a477e7444c7f8deb69565051b888

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Akademický článek

Persistence of functional memory B cells recognizing SARS-CoV-2 variants despite loss of specific IgG

Autor: Stephan Winklmeier, Katharina Eisenhut, Damla Taskin, Heike Rübsamen, Ramona Gerhards, Celine Schneider, Paul R. Wratil, Marcel Stern, Peter Eichhorn, Oliver T. Keppler, Matthias Klein, Simone Mader, Tania Kümpfel, Edgar Meinl

Publikováno v: iScience, Vol 25, Iss 1, Pp 103659- (2022)

Summary: Although some COVID-19 patients maintain SARS-CoV-2-specific serum immunoglobulin G (IgG) for more than 6 months postinfection, others eventually lose IgG levels. We assessed the persistence of SARS-CoV-2-specific B cells in 17 patients, 5 o

Externí odkaz: https://doaj.org/article/421780233e7e4232a603f35bf55f7e8d

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Dissection of complement and Fc-receptor-mediated pathomechanisms of autoantibodies to myelin oligodendrocyte glycoprotein

Autor: Simone Mader, Samantha Ho, Hoi Kiu Wong, Selia Baier, Stephan Winklmeier, Carolina Riemer, Heike Rübsamen, Iris Marti Fernandez, Ramona Gerhards, Cuilian Du, Omar Chuquisana, Jan D. Lünemann, Anja Lux, Falk Nimmerjahn, Monika Bradl, Naoto Kawakami, Edgar Meinl

Publikováno v: Proceedings of the National Academy of Sciences. 120

Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) have recently been established to define a new disease entity, MOG-antibody-associated disease (MOGAD), which is clinically overlapping with multiple sclerosis. MOG-specific antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0876a6e6f754c6ad58af4d0629ff1c9c
https://doi.org/10.1073/pnas.2300648120

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Persistence of functional memory B cells recognizing SARS-CoV-2 variants despite loss of specific IgG

Publikováno v: iScience, Vol 25, Iss 1, Pp 103659-(2022)
iScience

While some COVID-19 patients maintain SARS-CoV-2-specific serum IgGs for more than 6 months post-infection, others eventually lose IgG levels. We assessed the persistence of SARS-CoV-2-specific B cells in 17 patients, five of whom had lost specific I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b5307ad25287af1b8446ccaaa70162
https://pubmed.ncbi.nlm.nih.gov/34957380

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Persistence of Functional Memory B Cells Recognizing SARS-CoV-2 Variants Despite Loss of Specific IgG

Autor: Oliver T. Keppler, Damla Taskin, Heike Rübsamen, Edgar Meinl, Simone Mader, Stephan Winklmeier, Matthias Klein, Peter Eichhorn, Tania Kümpfel, Celine Schneider, Katharina Eisenhut

Publikováno v: SSRN Electronic Journal.

While some COVID-19 patients maintain SARS-CoV-2-specific serum IgGs for more than 6 months post-infection, others, especially mild cases, eventually lose IgG levels. We aimed to assess the persistence of SARS-CoV-2-specific B cells in patients who h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::487343d483309a35e987bc6e16a7d86d
https://doi.org/10.2139/ssrn.3854495

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Late-onset tumor necrosis factor receptor–associated periodic syndrome in multiple sclerosis patients carrying theTNFRSF1A R92Q mutation

Autor: Lisa-Ann Hoffmann, Walter Pöllmann, Reinhard Hohlfeld, Wolfgang Feneberg, Tania Kümpfel, Peter Lohse, Heike Rübsamen

Publikováno v: Arthritis & Rheumatism. 56:2774-2783

Objective Tumor necrosis factor receptor–associated periodic syndrome (TRAPS) is an autosomal-dominantly inherited autoinflammatory disorder caused by mutations in the TNFRSF1A gene. It is characterized by episodes of autoinflammation usually assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8458ae734dc5057cc38dc48aaa37bc
https://doi.org/10.1002/art.22795

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γ-secretase directly sheds the survival receptor BCMA from plasma cells

Publikováno v: NATURE COMMUNICATIONS
Nature Communications 6(1), 7333 (2015). doi:10.1038/ncomms8333
Nature Communications
Nat. Commun. 6:7333 (2015)

Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ-secretase directly cleaves BCMA, without prior truncation by another protease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c43b69ff255cf7ef1e718fe09db17da
https://mediatum.ub.tum.de/doc/1349641/document.pdf

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Thrombophilic Gene Mutations and Recurrent Spontaneous Abortion: Prothrombin Mutation Increases the Risk in the First Trimester

Autor: Tina Buchholz, R. Pihusch, Christian J. Thaler, Erhard Hiller, Nina Rogenhofer, Uwe Hasbargen, Peter Lohse, Heike Rübsamen

Publikováno v: American Journal of Reproductive Immunology. 46:124-131

PROBLEM: Thrombophilic predisposition may be one of the underlying causes of recurrent spontaneous abortions (RSA). We studied the prevalence of five thrombophilic gene mutations in patients with RSA. METHOD OF STUDY: 102 patients with two or more co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dea1b58cbb3cc870276d1e562e525d
https://doi.org/10.1111/j.8755-8920.2001.460202.x

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