Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Heike Overwin"'
Publikováno v:
mSystems, Vol 6, Iss 4 (2021)
ABSTRACT The design of novel antibiotics relies on a profound understanding of their mechanism of action. While it has been shown that cellular effects of antibiotics cluster according to their molecular targets, we investigated whether compounds bin
Externí odkaz:
https://doaj.org/article/e708be2126b94522ba7b743449dfa498
Publikováno v:
ACS Infectious Diseases. 9:567-581
Publikováno v:
SSRN Electronic Journal.
The design of novel antibiotics relies on a profound understanding of their mechanism of action. While it has been shown that cellular effects of antibiotics cluster according to their molecular targets, we investigated whether compounds binding to d
Publikováno v:
Applied Microbiology And Biotechnology
Artículos CONICYT
CONICYT Chile
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Artículos CONICYT
CONICYT Chile
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The bacterial dioxygenation of mono- or polycyclic aromatic compounds is an intensely studied field. However, only in a few cases has the repeated dioxygenation of a substrate possessing more than a single aromatic ring been described. We previously
Publikováno v:
Applied Microbiology and Biotechnology. 99:9565-9576
Flavonoids are known to possess a multitude of biological activities. Therefore, diversification of the core structures is of considerable interest. One of nature's important tailoring reactions in the generation of bioactive compounds is glycosylati
Publikováno v:
Journal Of Biotechnology
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CONICYT Chile
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Artículos CONICYT
CONICYT Chile
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Flavonoids possess a wide range of biological activities. Their glycosylation is of considerable interest, as it often positively influences their pharmacokinetic and other molecular properties. We recently showed that two non-Leloir glycosyltransfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746a4d723b5a39901b3d1738e8498f59
Publikováno v:
Applied and Environmental Microbiology. 75:7453-7460
An amylosucrase gene was subjected to high-rate segmental random mutagenesis, which was directed toward a segment encoding amino acids that influence the interaction with substrate molecules in subsites −1 to +3. A screen was used to identify enzym
Autor:
Myriam González, Heike Overwin, Joachim Reichelt, Christine Standfuß-Gabisch, Valentina Méndez, Victor Wray, Michael Seeger, Bernd Hofer
Publikováno v:
Microbiology-Sgm
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CONICYT Chile
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Artículos CONICYT
CONICYT Chile
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It has repeatedly been shown that aryl-hydroxylating dioxygenases do not possess a very high substrate specificity. To gain more insight into this phenomenon, we examined two powerful biphenyl dioxygenases, the well-known wild-type enzyme from Burkho
Publikováno v:
Journal of biotechnology. 211
Glycosylation is one of the most important tailoring reactions for natural products. It typically exerts profound direct or indirect effects on their biological activity. The dihydrochalcone phloretin and its known sugar derivatives, particularly phl
Autor:
Heike Overwin, Valentina Méndez, Myriam González, Michael Seeger, Franco Cárdenas, Bernd Hofer
Publikováno v:
Enzyme And Microbial Technology
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Flavonoids are a large group of plant secondary metabolites that exert various biological and pharmacological effects. In this context, the generation of derivatives is of considerable interest. The introduction of hydroxy groups is of particular rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee90fec1973aeceb94b048de458b0e60