Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Heike N. Pfäffle"'
Autor:
Henning Willers, Lee Zou, Lecia V. Sequist, Cyril H. Benes, Jeffrey Settleman, Kerstin Borgmann, Patricia Greninger, Natalie Ferraiolo, Liliana Gheorghiu, Meng Wang, Heike N. Pfäffle
PDF file, 24K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb19b9ffce3c438ad0deaedc4d8cd20
https://doi.org/10.1158/0008-5472.22397543
https://doi.org/10.1158/0008-5472.22397543
Autor:
Henning Willers, Lee Zou, Lecia V. Sequist, Cyril H. Benes, Jeffrey Settleman, Kerstin Borgmann, Patricia Greninger, Natalie Ferraiolo, Liliana Gheorghiu, Meng Wang, Heike N. Pfäffle
PDF file, 1491K, Fig. S1-3 describe crosslinker sensitivity of EGFR mutant cells, Fig. S4 details a FANCD2/FAN1 defect in interstrand crosslink incision, Fig. S5-7 characterizes the homologous recombination phenotype of EGFR mutant cells, and Fig. S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab41258b780b2ee1a91808ffc9b7cde
https://doi.org/10.1158/0008-5472.22397546
https://doi.org/10.1158/0008-5472.22397546
Autor:
Henning Willers, Lee Zou, Lecia V. Sequist, Cyril H. Benes, Jeffrey Settleman, Kerstin Borgmann, Patricia Greninger, Natalie Ferraiolo, Liliana Gheorghiu, Meng Wang, Heike N. Pfäffle
PDF file, 51K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea2f4d0591ae2a4f39e77cac9e567b2
https://doi.org/10.1158/0008-5472.22397549
https://doi.org/10.1158/0008-5472.22397549
Autor:
Kankana Bardhan, Heike N. Pfäffle, Henning Willers, Liliana Gheorghiu, Lynnette Marcar, Meng Wang, Jeffrey Settleman, Qi Liu, Kerstin Borgmann, Aaron N. Hata, Zofia Piotrowska, Jeffrey A. Engelman, Lecia V. Sequist, Patrick H Dinkelborg
Publikováno v:
Cell reports
Cell Reports, Vol 27, Iss 12, Pp 3422-3432.e4 (2019)
Cell Reports, Vol 27, Iss 12, Pp 3422-3432.e4 (2019)
SUMMARY Lung cancers with oncogenic mutations in the epidermal growth factor receptor (EGFR) invariably acquire resistance to tyrosine kinase inhibitor (TKI) treatment. Vulnerabilities of EGFR TKI-resistant cancer cells that could be therapeutically
Autor:
Patricia Greninger, Heike N. Pfäffle, Cyril H. Benes, Natalie Ferraiolo, Lee Zou, Lecia V. Sequist, Kerstin Borgmann, Liliana Gheorghiu, Henning Willers, Jeffrey Settleman, Meng Wang
Publikováno v:
Cancer research. 73(20)
In patients with lung cancer whose tumors harbor activating mutations in the EGF receptor (EGFR), increased responses to platinum-based chemotherapies are seen compared with wild-type cancers. However, the mechanisms underlying this association have
Autor:
Susan Ashwell, Anthony J. Berdis, David A. Boothman, Djane Braz Duarte, Nicola J. Curtin, Yvette Drew, Melissa L. Fishel, Millie M. Georgiadis, Stanton L. Gerson, Mark R. Kelley, Susan P. Lees-Miller, Long Shan Li, Yuan Lin, Lili Liu, Srinivasan Madhusudan, Mark Meyers, Asima Mukhopadhyay, Steve M. Patrick, Christina Perry, Heike N. Pfäffle, Ruth Plummer, Rebeka Sultana, John J. Turchi, Carlo Vascotto, Michael R. Vasko, Mark Wagner, Michael Weinfeld, Henning Willers, Lee Zou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7a952fa58933f1057c0fca76bc703ab
https://doi.org/10.1016/b978-0-12-384999-1.10017-4
https://doi.org/10.1016/b978-0-12-384999-1.10017-4
Publisher Summary This chapter discusses the homologous recombination repair (HRR) in cancer. The process of HRR can be roughly divided into four phases: resection of DNA ends; formation of RAD51 filament; strand invasion and Holliday junction (HJ) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a8a81621fa24083f05f452ee64bff13
https://doi.org/10.1016/b978-0-12-384999-1.10007-1
https://doi.org/10.1016/b978-0-12-384999-1.10007-1
Autor:
Johnathan R. Whetstine, Henning Willers, Carl O'Hara, Lee Zou, Lisa A. Kachnic, Michael I. Ebright, Heike N. Pfäffle, Cheryl Spencer, Moritz Birkelbach, Natalie Ferraiolo, Lecia V. Sequist, Jochen Dahm-Daphi, Cyril H. Benes, Liliana Gheorghiu, Benedict D.T. Daly
Publikováno v:
Journal of Thoracic Oncology. (3):279-286
Introduction Homologous recombination repair (HRR) is a critical pathway for the repair of DNA damage caused by cisplatin or poly-ADP ribose polymerase (PARP) inhibitors. HRR may be impaired by multiple mechanisms in cancer, which complicates assessi