Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Heike M Kropp"'
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188005 (2017)
Archaeal B-family polymerases drive biotechnology by accepting a wide substrate range of chemically modified nucleotides. By now no structural data for archaeal B-family DNA polymerases in a closed, ternary complex are available, which would be the b
Externí odkaz:
https://doaj.org/article/d582794c8b6d439da59666c99529901b
Autor:
Pulak Ghosh, Heike M. Kropp, Karin Betz, Samra Ludmann, Kay Diederichs, Andreas Marx, Seergazhi G. Srivatsan
Publikováno v:
Journal of the American Chemical Society. 144(23)
DNA polymerases can process a wide variety of structurally diverse nucleotide substrates, but the molecular basis by which the analogs are processed is not completely understood. Here, we demonstrate the utility of environment-sensitive heterocycle-m
Publikováno v:
Chembiochem
With increasing temperature, nucleobases in DNA become increasingly damaged by hydrolysis of exocyclic amines. The most prominent damage includes the conversion of cytosine to uracil and adenine to hypoxanthine. These damages are mutagenic and put th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd571b40f7577006cdd0004d7b3c2ace
Publikováno v:
Angewandte Chemie International Edition. 58:5457-5461
Archaeal B-family DNA polymerases (DNA pols) are the driving force of cutting-edge biotechnological applications like next-generation sequencing. The acceptance of chemically modified nucleotides by DNA pols is key to these technologies. Until now, n
Publikováno v:
Angewandte Chemie. 131:5512-5516
Archaeale B‐Familien‐DNA‐Polymerasen (DNA‐Pols) sind die treibende Kraft führender biotechnologischer Anwendungen wie moderne Sequenzierungsansätze. Die Akzeptanz chemisch modifizierter Nukleotide durch DNA‐Pols ist der Schlüssel zu dies
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Despite being evolved to process the four canonical nucleotides, DNA polymerases are known to incorporate and extend from modified nucleotides, which is the key to numerous core biotechnology applications. The structural basis for postin
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 22(31)
Microcystins are cyanobacterial toxins that can be found in fresh and coastal waters during algal blooms. Microcystin contamination of water can cause severe poisoning of animals and humans. Quantification of these toxins in biological samples is com