Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Heike L, Pahl"'
Publikováno v:
HemaSphere, Vol 5, Iss 5, p e565 (2021)
Even after development of the JAK1/JAK2 inhibitor ruxolitinib, myeloproliferative neoplasm (MPN) patients require novel therapeutic options. While ruxolitinib can considerably improve quality of life and prolong survival, it does not modify the natur
Externí odkaz:
https://doaj.org/article/f66e03f2b42847d99e9a14da8384fb4f
Autor:
Jonas S. Jutzi, Maria Kleppe, Jennifer Dias, Hans Felix Staehle, Kaitlyn Shank, Julie Teruya-Feldstein, Sudheer Madan Mohan Gambheer, Christine Dierks, Hugh Y. Rienhoff, Jr, Ross L. Levine, Heike L. Pahl
Publikováno v:
HemaSphere, Vol 2, Iss 3 (2018)
Abstract. Despite recent advances, the myeloproliferative neoplasms (MPNs) are attended by considerable morbidity and mortality. Janus kinase (Jak) inhibitors such as ruxolitinib manage symptoms but do not substantially change the natural history of
Externí odkaz:
https://doaj.org/article/9a5226cfef28450b8b2347a82de72292
Autor:
Holly L. Geyer, Heidi Kosiorek, Amylou C. Dueck, Robyn Scherber, Stefanie Slot, Sonja Zweegman, Peter AW te Boekhorst, Zhenya Senyak, Harry C. Schouten, Federico Sackmann, Ana Kerguelen Fuentes, Dolores Hernández-Maraver, Heike L. Pahl, Martin Griesshammer, Frank Stegelmann, Konstanze Döhner, Thomas Lehmann, Karin Bonatz, Andreas Reiter, Francoise Boyer, Gabriel Etienne, Jean-Christophe Ianotto, Dana Ranta, Lydia Roy, Jean-Yves Cahn, Claire N. Harrison, Deepti Radia, Pablo Muxi, Norman Maldonado, Carlos Besses, Francisco Cervantes, Peter L. Johansson, Tiziano Barbui, Giovanni Barosi, Alessandro M. Vannucchi, Chiara Paoli, Francesco Passamonti, Bjorn Andreasson, Maria L Ferrari, Alessandro Rambaldi, Jan Samuelsson, Keith Cannon, Gunnar Birgegard, Zhijian Xiao, Zefeng Xu, Yue Zhang, Xiujuan Sun, Junqing Xu, Jean-Jacques Kiladjian, Peihong Zhang, Robert Peter Gale, Ruben A. Mesa
Publikováno v:
Haematologica, Vol 102, Iss 1 (2017)
The myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and myelofibrosis, are distinguished by their debilitating symptom profiles, life-threatening complications and profound impact on quality of life. The role gend
Externí odkaz:
https://doaj.org/article/b8f3bfa30986447c9692146db10cad5d
Autor:
Wei Wang, Jan Breucker, Heike L. Pahl, Lukas Clemens Böckelmann, Albert Gründer, Andrea Pichler, Titiksha Basu, Sandra Kaiser
Publikováno v:
Haematologica
Autor:
Monika Gothwal, Julius Wehrle, Konrad Aumann, Vanessa Zimmermann, Albert Gründer, Heike L. Pahl
Publikováno v:
Haematologica, Vol 101, Iss 9 (2016)
We have recently demonstrated that the transcription factor nuclear factor-erythroid 2, which is critical for erythroid maturation and globin gene expression, plays an important role in the pathophysiology of myeloproliferative neoplasms. Myeloprolif
Externí odkaz:
https://doaj.org/article/145ed68bc4904fa882aec86cc1be5729
Autor:
Christoph Koellerer, Albert Gründer, Mathijs A. Sanders, Manuela Simoni, Laura Riccetti, Heike L. Pahl, Jerzy-Roch Nofer, Peter J. M. Valk, Jonas S. Jutzi, Carsten Müller-Tidow, Fengbiao Zhou, Samuel Vorbach, Francesco Potì
Publikováno v:
Leukemia, 34(3), 721-734. Nature Publishing Group
Acute myeloid leukemia (AML) carries a 10–100 fold lower mutational burden than other neoplastic entities. Mechanistic explanations for why a low number of mutations suffice to induce leukemogenesis are therefore required. Here we demonstrate that
Autor:
Judith Gecht, Stefani Parmentier, Joachim R. Göthert, Mathias Hänel, Uwe Platzbecker, Tim H. Brümmendorf, Steffen Koschmieder, Christoph Maintz, Richard A. Hansen, Kim Kricheldorf, Martin Kirschner, Fabian Lang, Katja Sockel, Heike L. Pahl, Haifa Kathrin Al-Ali, Ioannis Tsoukakis, Susanne Isfort, Holger Schulz, Norbert Gattermann, Martin Griesshammer, Frank Stegelmann, Konstanze Döhner, Martin Bommer, Martine Klausmann, Florian H Heidel, Wiebke Hollburg
Publikováno v:
Cancers 13(16), 4086 (2021). doi:10.3390/cancers13164086 special issue: "Special Issue "Advances in the Pathobiology, Diagnosis and Treatment of Chronic Myeloid Neoplasms" / Special Issue Editors: Dr. Luis Colomo, Guest Editor; Dr. Xavier Calvo, Guest Editor"
Cancers
Volume 13
Issue 16
Cancers, Vol 13, Iss 4086, p 4086 (2021)
Cancers
Volume 13
Issue 16
Cancers, Vol 13, Iss 4086, p 4086 (2021)
Inflammation-induced thrombosis represents a severe complication in patients with myeloproliferative neoplasms (MPN) and in those with kidney dysfunction. Overlapping disease-specific attributes suggest common mechanisms involved in MPN pathogenesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e59d1837a28a0dea1e297b449541b2
http://publikationen.ub.uni-frankfurt.de/files/62188/container.zip
http://publikationen.ub.uni-frankfurt.de/files/62188/container.zip
Autor:
Jonas S. Jutzi, Heike L. Pahl
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
It has been known for some time that solid tumors, especially gastrointestinal tumors, can arise on the basis of chronic inflammation. However, the role of inflammation in the genesis of hematological malignancies has not been extensively studied. Re
Externí odkaz:
https://doaj.org/article/bfeb900c488f4faf9e63fcde3208af3d
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 144:489-493
Scientifically active medical doctors are required for successful translation of novel basic findings into the clinic. However, there is an increasing tendency of young medical doctors to primarily follow a more clinically and not scientifically orie
Autor:
Mathijs A. Sanders, Sandra Kaiser, Wei Wang, Sarolta Bojtine Kovacs, Lars Bullinger, Bruno Cassinat, Annelieke Zeilemaker, Christoph Koellerer, Peter J. M. Valk, Jonas S. Jutzi, Titiksha Basu, Adil Al Hinai, Jenny Ostendorp, Brigitte Schlegelberger, Heike L. Pahl, Emmanuel Raffoux, Doris Steinemann, Maximilian Pellmann, Konrad Aumann
Publikováno v:
Blood, 133(16), 1766-1777. American Society of Hematology
In acute myeloid leukemia (AML), acquired genetic aberrations carry prognostic implications and guide therapeutic decisions. Clinical algorithms have been improved by the incorporation of novel aberrations. Here, we report the presence and functional