Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Heike Kroeger"'
Autor:
Eun-Jin Lee, Monica S. Diaz-Aguilar, Hyejung Min, Jihee Choi, Diego A. Valdez Duran, Julia M. Grandjean, R. Luke Wiseman, Heike Kroeger, Jonathan H. Lin
Publikováno v:
The American journal of pathology.
Activating transcription factor 6 (ATF6), a key regulator of the unfolded protein response, is required for endoplasmic reticulum function and protein homeostasis. Variants of ATF6 that abrogate transcriptional activity cause morphologic and molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2c01497c84b30a0f3664e6f834e457
https://pubmed.ncbi.nlm.nih.gov/36535406
https://pubmed.ncbi.nlm.nih.gov/36535406
Autor:
Jonathan H. Lin, R. Luke Wiseman, Jennifer Okalova, Michel Michaelides, Amanda Nguyen, Daphne D. Bindels, Rebecca Mastey, Joseph Carroll, Evan T. Powers, Julia M. D. Grandjean, Wei-Chieh Jerry Chiang, Jeffery W. Kelly, Heike Kroeger, Neil Grimsey
Publikováno v:
Proc Natl Acad Sci U S A
Endoplasmic reticulum (ER) stress and Unfolded Protein Response (UPR) signaling promote the pathology of many human diseases. Loss-of-function variants of the UPR regulator Activating Transcription Factor 6 (ATF6) cause severe congenital vision loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8e1563d9e13e215fab976f8078c82a
https://pubmed.ncbi.nlm.nih.gov/34561305
https://pubmed.ncbi.nlm.nih.gov/34561305
Autor:
Jonathan H. Lin, Patricia M. Gaffney, John H. Kim, Heike Kroeger, Christina J. Sigurdson, Jerry Yang, Kevin J. Cao
Publikováno v:
Translational Vision Science & Technology
Purpose To investigate the use of an amyloid-targeting fluorescent probe, ARCAM-1, to identify amyloid-containing deposits in the retina of a transgenic mouse model of Alzheimer's disease (AD) and in human postmortem AD patients. Methods Aged APP/PS1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7791131ece7f273b5c84647881e6b5c
http://europepmc.org/articles/PMC8185402
http://europepmc.org/articles/PMC8185402
Autor:
Wei-Chieh Chiang, R. Luke Wiseman, Joseph Carroll, Amanda Nguyen, Julia M. D. Grandjean, Heike Kroeger, Jennifer Okalova, Jonathan H. Lin, Neil Grimsey, Evan T. Powers, Michel Michaelides, Jeffery W. Kelly, Daphne S. Bindels, Rebecca Mastey
Dysregulation of the endoplasmic reticulum (ER) Unfolded Protein Response (UPR) is implicated in the pathology of many human diseases associated with ER stress. Inactivating genetic variants in the UPR regulator Activating Transcription Factor 6 (ATF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::913b5b7d900ab5ff510d3883f7ce149e
https://doi.org/10.1101/2020.10.04.325019
https://doi.org/10.1101/2020.10.04.325019
Autor:
Daniel L. Chao, Jonathan H. Lin, Anthony T. Moore, Isabelle Audo, Rebecca Mastey, Chloe Xiaoke Bi, Dorota Skowronska-Krawczyk, Britta Baumann, Kyle Kim, Leon Chea, Wei-Chieh Chiang, Susanne Kohl, R. Luke Wiseman, Joseph Carroll, Eun-Jin Lee, Scott R. Lambert, Heike Kroeger, Julia M. D. Grandjean, Stephen H. Tsang
Publikováno v:
JCI Insight
Achromatopsia (ACHM) is an autosomal recessive disease that results in severe visual loss. Symptoms of ACHM include impaired visual acuity, nystagmus, and photoaversion starting from infancy; furthermore, ACHM is associated with bilateral foveal hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07103649fff10916483bdc2183095dca
https://doi.org/10.1172/jci.insight.136041
https://doi.org/10.1172/jci.insight.136041
Autor:
Daphne S. Bindels, Amanda Nguyen, Jonathan H. Lin, Julia M. D. Grandjean, Wei-Chieh Chiang, Rebecca Mastey, Michel Michaelides, Evan T. Powers, Jeffery W. Kelly, Joseph Carroll, Heike Kroeger, R. Luke Wiseman, Jennifer Okalova, Neil Grimsey
Publikováno v:
SSRN Electronic Journal.
Dysregulation of the endoplasmic reticulum (ER) Unfolded Protein Response (UPR) is implicated in the pathology of many human diseases associated with ER stress. Inactivating genetic variants in the UPR regulator Activating Transcription Factor 6 (ATF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf0e3fc0f7e1e9394554248171388bb
https://doi.org/10.2139/ssrn.3746623
https://doi.org/10.2139/ssrn.3746623
Publikováno v:
The FEBS Journal. 286:399-412
The human eye is the organ that is able to react to light in order to provide sharp three-dimensional and colored images. Unfortunately, the health of the eye can be impacted by various stimuli that can lead to vision loss, such as environmental chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccaf6abef2ee12ed247c63b4795e5aa3
https://doi.org/10.1111/febs.14522
https://doi.org/10.1111/febs.14522
Publikováno v:
Adv Exp Med Biol
Retinal Degenerative Diseases ISBN: 9783030273774
Retinal Degenerative Diseases ISBN: 9783030273774
Activating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR). In response to endoplasmic reticulum (ER) stress, ATF6 is transported from the ER to the Golgi apparatus where it is cleaved by intramembrane proteoly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872c5a8482318315905f89b0775dec2d
https://pubmed.ncbi.nlm.nih.gov/31884629
https://pubmed.ncbi.nlm.nih.gov/31884629
Autor:
JoAnn Trejo, Heike Kroeger, Jonathan H. Lin, Ryan J Paxman, Wei-Chieh Chiang, Ying Jones, Neil Grimsey, Stephen H. Tsang, Jeffery W. Kelly, Lars Plate, Peter X. Shaw, R. Luke Wiseman, Evan T. Powers
Publikováno v:
Science signaling, vol 11, iss 517
ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress. Deletion of the isoform activating transcription factor 6α (ATF6α) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce310a1fe90e4ff2d3ad62ded0ce9a3
https://doi.org/10.1126/scisignal.aan5785
https://doi.org/10.1126/scisignal.aan5785
Autor:
S. Yu, C. E. Bueso-Ramos, Steve Kornblau, Jaroslav Jelinek, Andrew Kelly, Rong He, Yue Lu, Justin T. Lee, Matteo Cesaroni, Rodolphe Taby, Farhad Ravandi, Shoudan Liang, Sherry Pierce, Y. Li, Frank Neumann, Jean Pierre J. Issa, Bela Patel, Jumpei Yamazaki, Heike Kroeger, Hagop M. Kantarjian
Publikováno v:
Leukemia
Genetic changes are infrequent in acute myeloid leukemia (AML) compared with other malignancies and often involve epigenetic regulators, suggesting that an altered epigenome may underlie AML biology and outcomes. In 96 AML cases including 65 pilot sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcbf18e2f1a2c29a53538ffc554bd31
https://pubmed.ncbi.nlm.nih.gov/28074068
https://pubmed.ncbi.nlm.nih.gov/28074068