Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Heike Krebber"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Telomerases elongate the ends of chromosomes required for cell immortality through their reverse transcriptase activity. By using the model organism Saccharomyces cerevisiae we defined the order in which the holoenzyme matures. First, a long
Externí odkaz:
https://doaj.org/article/4377d5e1eb81413e8797c3d7b71c3737
Autor:
Yen-Yun Lu, Heike Krebber
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11275 (2021)
Pre-mRNA splicing is critical for cells, as defects in this process can lead to altered open reading frames and defective proteins, potentially causing neurodegenerative diseases and cancer. Introns are removed in the nucleus and splicing is document
Externí odkaz:
https://doaj.org/article/83eb7297dbd2424f935a3675434e043b
Autor:
Idan Frumkin, Ido Yofe, Raz Bar-Ziv, Yonat Gurvich, Yen-Yun Lu, Yoav Voichek, Ruth Towers, Dvir Schirman, Heike Krebber, Yitzhak Pilpel
Publikováno v:
PLoS Biology, Vol 17, Iss 8, p e3000423 (2019)
Splicing expands, reshapes, and regulates the transcriptome of eukaryotic organisms. Despite its importance, key questions remain unanswered, including the following: Can splicing evolve when organisms adapt to new challenges? How does evolution opti
Externí odkaz:
https://doaj.org/article/6c40cee53baf4283b3193a27124621e8
Autor:
Daniel Becker, Anna Greta Hirsch, Lysann Bender, Thomas Lingner, Gabriela Salinas, Heike Krebber
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3199-3214.e3 (2019)
Summary: Removal of introns from pre-mRNAs is an essential step in eukaryotic gene expression, mediated by spliceosomes that contain snRNAs as key components. Although snRNAs are transcribed in the nucleus and function in the same compartment, all ex
Externí odkaz:
https://doaj.org/article/9990dcb50b3c4e3cb5ffc0099916c3d1
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 1085 (2020)
The DEAD-box protein Dbp5 (human DDX19) remodels RNA-protein complexes. Dbp5 functions in ribonucleoprotein export and translation termination. Termination occurs, when the ribosome has reached a stop codon through the Dbp5 mediated delivery of the e
Externí odkaz:
https://doaj.org/article/0ae79be5c5a246838e00ff71fd5f9d05
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1630-1638 (2014)
Telomerases protect the ends of linear chromosomes from shortening. They are composed of an RNA (TLC1 in S. cerevisiae) and several proteins. TLC1 undergoes several maturation steps before it is exported into the cytoplasm to recruit the Est proteins
Externí odkaz:
https://doaj.org/article/c60cb618ce604010b5de626f23d4c162
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149571 (2016)
The DEAD-box RNA-helicase Dbp5/Rat8 is known for its function in nuclear mRNA export, where it displaces the export receptor Mex67 from the mRNA at the cytoplasmic side of the nuclear pore complex (NPC). Here we show that Dbp5 is also required for th
Externí odkaz:
https://doaj.org/article/72ef0a362be247f888c7e23bb2741d58
Autor:
Vijayalakshmi Kari, Oleksandra Karpiuk, Bettina Tieg, Malte Kriegs, Ekkehard Dikomey, Heike Krebber, Yvonne Begus-Nahrmann, Steven A Johnsen
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63745 (2013)
Unlike other metazoan mRNAs, replication-dependent histone gene transcripts are not polyadenylated but instead have a conserved stem-loop structure at their 3' end. Our previous work has shown that under certain conditions replication-dependent histo
Externí odkaz:
https://doaj.org/article/4b61d1df694d494eac1d9c077cfa29ef
Accurate translation requires correct mRNAs with intact open reading frames. Cells eliminate defective transcripts to prevent mistranslation by three cytoplasmic mRNA quality control events termed nonsense-mediated decay (NMD), no-go decay (NGD) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d0af50265893cded99ec33e7490e808
https://doi.org/10.1101/2022.11.11.516101
https://doi.org/10.1101/2022.11.11.516101
Publikováno v:
Nucleic acids research. 50(19)
Efficient gene expression requires properly matured mRNAs for functional transcript translation. Several factors including the guard proteins monitor maturation and act as nuclear retention factors for unprocessed pre-mRNAs. Here we show that the gua