Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Heike Heuer"'
Autor:
Simon Ullrich, Susanne Leidescher, Yana Feodorova, Katharina Thanisch, Jean-Baptiste Fini, Bernd Kaspers, Frank Weber, Boyka Markova, Dagmar Führer, Mirian Romitti, Stefan Krebs, Helmut Blum, Heinrich Leonhardt, Sabine Costagliola, Heike Heuer, Irina Solovei
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Abnormalities are indispensable for studying normal biological processes and mechanisms. In the present work, we draw attention to the remarkable phenomenon of a perpetually and robustly upregulated gene, the thyroglobulin gene (Tg). The gene is expr
Externí odkaz:
https://doaj.org/article/90f08466957648079f8c4cfd025f892b
Autor:
Steffen Mayerl, Heike Heuer
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106195- (2023)
Proper CNS myelination depends on the timed availability of thyroid hormone (TH) that induces differentiation of oligodendrocyte precursor cells (OPCs) to mature, myelinating oligodendrocytes. Abnormal myelination is frequently observed in Allan-Hern
Externí odkaz:
https://doaj.org/article/82204e6fc8a141dda542879f11045c62
Autor:
Devon Siemes, Pieter Vancamp, Boyka Markova, Philippa Spangenberg, Olga Shevchuk, Bente Siebels, Hartmut Schlüter, Steffen Mayerl, Heike Heuer, Daniel Robert Engel
Publikováno v:
Cells, Vol 12, Iss 20, p 2487 (2023)
Thyroid hormone (TH) transporter MCT8 deficiency causes severe locomotor disabilities likely due to insufficient TH transport across brain barriers and, consequently, compromised neural TH action. As an established animal model for this disease, Mct8
Externí odkaz:
https://doaj.org/article/9daf7929363549849adde0c41515077e
Autor:
Shalmali Shukla, Ronny Haenold, Pavel Urbánek, Lucien Frappart, Shamci Monajembashi, Paulius Grigaravicius, Sigrun Nagel, Woo Kee Min, Alicia Tapias, Olivier Kassel, Heike Heuer, Zhao-Qi Wang, Aspasia Ploubidou, Peter Herrlich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Cilia, tiny outgrowths of cells, are essential for life. Here, the author’s describe the scaffold protein TRIP6, which promotes the assembly of ciliary proteins required for ciliogenesis, and show that its absence results in hydrocephalus.
Externí odkaz:
https://doaj.org/article/4652349346cd445aaa9dd98d42752636
Autor:
Jiesi Chen, Eva Salveridou, Lutz Liebmann, Sivaraj M. Sundaram, Denica Doycheva, Boyka Markova, Christian A. Hübner, Anita Boelen, W. Edward Visser, Heike Heuer, Steffen Mayerl
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3452 (2023)
Patients with inactive thyroid hormone (TH) transporter MCT8 display intellectual disability due to compromised central TH transport and action. As a therapeutic strategy, application of thyromimetic, MCT8-independent compounds Triac (3,5,3′-triiod
Externí odkaz:
https://doaj.org/article/b518b5239fc54f72b48ee7a8ed4a2a0e
Autor:
Jonathan Rochus Reinwald, Wolfgang Weber-Fahr, Alejandro Cosa-Linan, Robert Becker, Markus Sack, Claudia Falfan-Melgoza, Natalia Gass, Urs Braun, Christian Clemm von Hohenberg, Jiesi Chen, Steffen Mayerl, Thomas F. Muente, Heike Heuer, Alexander Sartorius
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15547 (2022)
Dysfunctions of the thyroid hormone (TH) transporting monocarboxylate transporter MCT8 lead to a complex X-linked syndrome with abnormal serum TH concentrations and prominent neuropsychiatric symptoms (Allan-Herndon-Dudley syndrome, AHDS). The key fe
Externí odkaz:
https://doaj.org/article/b17a096e4ee24540b38a66f581cd9dbf
Autor:
Mirjam Kowallick, Meray Serdar, Boyka Markova, Eva Salveridou, Ursula Felderhoff-Müser, Dagmar Führer-Sakel, Heike Heuer, Ivo Bendix, Monia Vanessa Dewan
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Introduction: High oxygen concentrations have been identified as one factor contributing to the pathogenesis of the retinopathia of prematurity, chronic lung disease of the preterm infant and preterm brain injury. Preterm infants also show short- and
Externí odkaz:
https://doaj.org/article/138dbbdb788b46cdaa8e5162bb9912ab
Autor:
Steffen Mayerl, Andrea Alcaide Martin, Reinhard Bauer, Markus Schwaninger, Heike Heuer, Charles ffrench-Constant
Publikováno v:
Cells, Vol 11, Iss 3, p 524 (2022)
Inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) result in Allan-Herndon-Dudley Syndrome, a severe form of psychomotor retardation, while inactivating mutations in another TH transporter, organic ani
Externí odkaz:
https://doaj.org/article/cadff88ca3ec42a3ac82d682554b6b7b
Autor:
Vaishnavi Venugopalan, Alaa Al-Hashimi, Jonas Weber, Maren Rehders, Maria Qatato, Eva K. Wirth, Ulrich Schweizer, Heike Heuer, François Verrey, Klaudia Brix
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5776 (2021)
Cathepsin K-mediated thyroglobulin proteolysis contributes to thyroid hormone (TH) liberation, while TH transporters like Mct8 and Mct10 ensure TH release from thyroid follicles into the blood circulation. Thus, thyroid stimulating hormone (TSH) rele
Externí odkaz:
https://doaj.org/article/4cce63c801f045b8aea1b66b775b36a6
Autor:
Huaibiao Li, Torsten Kroll, Jürgen Moll, Lucien Frappart, Peter Herrlich, Heike Heuer, Aspasia Ploubidou
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1071-1080 (2017)
Misoriented division of neuroprogenitors, by loss-of-function studies of centrosome or spindle components, has been linked to the developmental brain defects microcephaly and lissencephaly. As these approaches also affect centrosome biogenesis, spind
Externí odkaz:
https://doaj.org/article/66b2ab19282d4c5d851340fc91629165