Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Heike Gielen"'
Autor:
Christine Harloff, Hubert Trübel, Matthias Vennemann, Heike Gielen-Haertwig, Jan-Philip Kruse, Vincent Ruland
Publikováno v:
Drug Discovery Today. 24:1924-1929
In pharmaceutical R&D the strategic focus is on addressing areas of high unmet medical need. 'Unmet medical need' is a widely used term in the healthcare sector but a common definition does not exist. The current standard of care determines the curre
Autor:
Dieter Lang, Ulrich Rosentreter, Franz von Nussbaum, Heike Gielen-Haertwig, Volkhart Min-Jian Li, Michael Gerisch, Martin Bechem, Helmut Haning, Dagmar Karthaus, Leila Telan, Martina Schäfer, Lars Bärfacker, Joachim Mittendorf, Sonja Anlauf, Klemens Lustig, Adrian Tersteegen, Daniel Meibom, Jens Schamberger, Swen Allerheiligen, Fitzgerald Mary F, Stefan Schäfer, Martina Delbeck
Publikováno v:
Chemmedchem
Human neutrophil elastase (HNE) is a key protease for matrix degradation. High HNE activity is observed in inflammatory diseases. Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary dis
Autor:
Dieter Enders, Heike Gielen
Publikováno v:
Journal of Organometallic Chemistry. :70-80
Deprotonation of chiral triazolium salts and reaction of the resulting nucleophilic carbenes with suitable metal precursors leads to (carbene)transition metal complexes. These contain, depending on the geometry of the complex and the arrangement of t
Publikováno v:
Scopus-Elsevier
Reaction of N-alkyl-N-formyl hydrazines 1 with isolated or in situ generated imidoyl chlorides 3 is an efficient method for the synthesis of the hitherto hardly accessible 3,4-disubstituted l-alkyl-4H-l,2,4-triazol-l-ium salts 4,6.
Publikováno v:
Zeitschrift für Naturforschung B. 53:1035-1038
Metal complexes with a square-planar arrangement of ligands are frequently found for the late Transition Metals. The incorporation of C1-symmetrical planar ligands (e.g. nucleophilic carbenes) in an orientation perpendicular to the square-plane of th
Publikováno v:
European Journal of Inorganic Chemistry. 1998:913-919
Deprotonation of chiral triazolium salts 1 and reaction of the resulting nucleophilic carbenes with [(COD)RhCl]2 or [(NBD)RhCl]2 afforded square-planar complexes 2–6 in yields of 65–95%. The complexes contain an axis of chirality and a diastereom
Publikováno v:
Tetrahedron: Asymmetry. 8:3571-3574
(Triazolinylidene)rhodium(COD) complexes 1–3 containing an axis of chirality have been prepared with de =91–97%. The application of these complexes as catalysts in an asymmetric hydrosilylation reaction of methyl ketones 4–7 has been investigat
Publikováno v:
Chemische Berichte. 130:1253-1260
The chloro bridges of the dinuclear complexes [(.65-cymene)-RuCl2]2 and [(.5-C5Me5)RhCl2]2 can be cleaved by reaction wht an N-phenyltriazolium perchlorate (1) and a base, resulting in the formation of (carbene)metal complexes. In this manner, abstra
Publikováno v:
Chemische Berichte. 129:1483-1488
The reaction of three equiv. of a chiral imidazolium or triazolium perchlorate with one equiv. of Pd(OAc)2, an excess of NaI and a base leads to the corresponding chiral dicarbenediiodopalladium(II) complexes in chemical yields up to 98% and with the
Autor:
Santiago Figueroa-Pérez, Heike Gielen-Haertwig, Jens-Kerim Ergüden, Adam Nitsche, Rolf Grosser, Lars Bärfacker, Peter Kolkhof, Alexander Hillisch, Joachim Mittendorf, Alexander Kuhl, Heike Heckroth, Holger Paulsen, Karl-Heinz Schlemmer, Johannes Platzek
Publikováno v:
ChemMedChem. 7(8)
Aldosterone is a hormone that exerts manifold deleterious effects on the kidneys, blood vessels, and heart which can lead to pathophysiological consequences. Inhibition of the mineralocorticoid receptor (MR) is a proven therapeutic concept for the ma