Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Heike Dornhoff"'
Autor:
Martin Purtak, Christoph Daniel, Christian Bogdan, Raya Atreya, Julia L.C. Baier, Anna Katharina Koller, Jochen Mattner, Kerstin Amann, Robert Opoka, Heike Dornhoff, Tilman T. Rau, Regina Schey
Publikováno v:
Mucosal immunology
CD101 exerts negative-costimulatory effects in vitro, but its function in vivo remains poorly defined. CD101 is abundantly expressed on lymphoid and myeloid cells in intestinal tissues, but absent from naive splenic T cells. Here, we assessed the imp
Autor:
Stefan Wirtz, George D. Yancopoulos, Clemens Neufert, Christoph Becker, Massimo Fantini, Andrew J. Murphy, Heike Dornhoff, Margaret Karow, Hans-Anton Lehr, Peter R. Galle, David M. Valenzuela, Markus F. Neurath, Alexei Nikolaev, Sabine Huebner
Publikováno v:
The Journal of Immunology. 177:2760-2764
Although IL-12 and IL-23 share the common p40 subunit, IL-23, rather than IL-12, seems to drive the pathogenesis of experimental autoimmune encephalomyelitis and arthritis, because IL-23/p19 knockout mice are protected from disease. In contrast, we d
Autor:
Andrew N. J. McKenzie, Stefanie Steiner, Ari Waisman, Heike Dornhoff, Benno Weigmann, Hans-Anton Lehr, Stefan Wirtz, Michael Vieth, Katharina Gerlach, YouYi Hwang, Raja Atreya, Alexej Nikolaev, Markus F. Neurath, Frank Rosenbauer
Publikováno v:
Nature immunology. 15(7)
The molecular checkpoints that drive inflammatory bowel diseases are incompletely understood. Here we found more T cells expressing the transcription factor PU.1 and interleukin 9 (IL-9) in patients with ulcerative colitis. In an animal model, citrin
Autor:
Christoph Becker, Clemens Neufert, Susanne Rosfa, Jürgen Siebler, Heike Dornhoff, Dennis Strand, Stefan Tenzer, Jürgen Markl, Jonas Mudter, Markus F. Neurath, Stefan Wirtz
Publikováno v:
Gastroenterology. 142(5)
Background & Aims Transforming growth factor (TGF)-β signaling, which is down-regulated by the E3 ubiquitin ligase Smad ubiquitin regulating factor 2 (Smurf2), promotes development of cancer. We identified a splice variant of Smurf2 (ΔE2Smurf2) and
Autor:
Martin R. Berger, Wolfgang Herr, Imke Atreya, Christoph Becker, Carl C. Schimanski, Stefan Wirtz, Markus F. Neurath, Heike Dornhoff, Elke Schnürer, Peter R. Galle
Publikováno v:
Gut. 56(11)
An efficient cytolytic T cell function is essential for immune mediated rejection of colorectal cancer. However, the molecular mechanisms driving T cell mediated cancer rejection are still poorly understood. Here, we assessed the relevance of the T-b
Autor:
Katharina Gerlach, YouYi Hwang, Alexej Nikolaev, Raja Atreya, Heike Dornhoff, Stefanie Steiner, Hans-Anton Lehr, Stefan Wirtz, Michael Vieth, Ari Waisman, Frank Rosenbauer, Andrew N J McKenzie, Benno Weigmann, Markus F Neurath
Publikováno v:
Nature Immunology. 16:214-214
Autor:
Christoph Becker, Massimo Fantini, Peter R. Galle, G. D. Yancopoulus, D. M. Valenzuela, Andrew J. Murphy, S. Hübner, Stefan Wirtz, Hans-Anton Lehr, Markus F. Neurath, Margaret Karow, Alexei Nikolaev, Clemens Neufert, Heike Dornhoff
Publikováno v:
Zeitschrift für Gastroenterologie. 44
Publikováno v:
Gastroenterology. 142:S-864
Publikováno v:
International Journal of Interferon, Cytokine and Mediator Research. :51
Publikováno v:
Gastroenterology. 140:S-150