Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Heike C. Hawerkamp"'
Autor:
Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P. Cervantes, Annie M. Curtis, Heike C. Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E. Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J. S. Preston, Jamie M. O’Sullivan, Frederick J. Sheedy, Padraic Fallon, James S. O’Donnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
von Willebrand factor (VWF) plays a critical role in primary hemostasis following vascular injury by tethering platelets to exposed collagen. Here, VWF binding to macrophages is shown to trigger NF-κB activation and induce pro-inflammatory responses
Externí odkaz:
https://doaj.org/article/0abf998c232d43bcab767dde021ae471
Autor:
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O’Dowd, Laura O’Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O’Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Clinical outcomes from infection with SARS-CoV-2, the cause of the COVID-19 pandemic, are remarkably variable ranging from asymptomatic infection to severe pneumonia and death. One of the key drivers of this variability is differing trajectories in t
Externí odkaz:
https://doaj.org/article/55a248964b0f4c47b23b9c07a22af0be
Autor:
Alessio Mylonas, Heike C. Hawerkamp, Yichen Wang, Jiaqi Chen, Francesco Messina, Olivier Demaria, Stephan Meller, Bernhard Homey, Jeremy Di Domizio, Lucia Mazzolai, Alain Hovnanian, Michel Gilliet, Curdin Conrad
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cle
Externí odkaz:
https://doaj.org/article/d033bfd462684a7e9f4fe0c374da5b1b
Autor:
Heike C. Hawerkamp, Alina Domdey, Lisa Radau, Philipp Sewerin, Péter Oláh, Bernhard Homey, Stephan Meller
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background Tofacitinib is a novel Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. In clinical trials, the most common adverse events observed were nasopharyngitis,
Externí odkaz:
https://doaj.org/article/db036183d5b742958b42a6cb156bea3c
Autor:
Ruth Bone, Brian J Fennell, Amy Tam, Richard Sheldon, Karl Nocka, Sreeja Varghese, Chew Shun Chang, Heike C Hawerkamp, Aoife Yeow, Sean P Saunders, Emily Hams, Patrick T Walsh, Orla Cunningham, Padraic G Fallon
Publikováno v:
Antibody Therapeutics. 5:258-267
Background Interleukin (IL)25 has been implicated in tissue homeostasis at barrier surfaces and the initiation of type two inflammatory signaling in response to infection and cell injury across multiple organs. We sought to discover and engineer a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed95ecf98910c10515eaea5f5988f79
https://doi.org/10.1093/abt/tbac022
https://doi.org/10.1093/abt/tbac022
Autor:
Heike C. Hawerkamp, Padraic G. Fallon
Publikováno v:
Immunity. 55:575-577
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::924aee8218087d7366369af887e219bf
https://doi.org/10.1016/j.immuni.2022.03.014
https://doi.org/10.1016/j.immuni.2022.03.014
Autor:
Yichen Wang, Jeremy Di Domizio, Heike C Hawerkamp, Conrad Curdin, Alain Hovnanian, Lucia Mazzolai, Alessio Mylonas, Michel Gilliet, Bernhard Homey, Stephan Meller, Olivier Demaria
Rosacea is a common chronic inflammatory skin disease that is characterized by a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with high density of B. oleronius and increased activity of the serine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e258d5013ae4549b44ddf5af127a19
https://doi.org/10.21203/rs.3.rs-279140/v2
https://doi.org/10.21203/rs.3.rs-279140/v2
Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity
Autor:
Christian Schwartz, Viviane Schmidt, Andrea Deinzer, Heike C. Hawerkamp, Emily Hams, Jasmin Bayerlein, Ole Röger, Moritz Bailer, Christian Krautz, Amr El Gendy, Moustafa Elshafei, Helen M. Heneghan, Andrew E. Hogan, Donal O’Shea, Padraic G. Fallon
Publikováno v:
Science translational medicine. 14(635)
Obesity has become a major health problem in the industrialized world. Immune regulation plays an important role in adipose tissue homeostasis; however, the initial events that shift the balance from a noninflammatory homeostatic environment toward i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c88407d5b9c16196faf371e4557beba
https://pubmed.ncbi.nlm.nih.gov/35365775
https://pubmed.ncbi.nlm.nih.gov/35365775
Autor:
Peter Arne Gerber, Jean Krutmann, Péter Oláh, Heike C Hawerkamp, Afaque Ahmad Imtiyaz Momin, Michael S. Denison, Katharina M. Rolfes, Stefan T. Arold, Stephan Meller, Angeliki Datsi, Stephan Alexander Braun, Anatoly A. Soshilov, Andreas Kislat, Mario E. Lacouture, Marius Pollet, Bernhard Homey, Thomas Haarmann-Stemmann
Publikováno v:
Allergy
Background In recent years, the BRAF inhibitor vemurafenib has been successfully established in the therapy of advanced melanoma. Despite its superior efficacy, the use of vemurafenib is limited by frequent inflammatory cutaneous adverse events that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cd6a30fd6aaedb94e910270a68f368
https://doi.org/10.1111/all.13972
https://doi.org/10.1111/all.13972
Autor:
Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P. Cervantes, Annie M. Curtis, Heike C. Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E. Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J. S. Preston, Jamie M. O’Sullivan, Frederick J. Sheedy, Padraic Fallon, James S. O’Donnell
Publikováno v:
Nature communications. 13(1)
The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have identified additional biological roles for VWF, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6767667d28d0cffe16f525a587786949
https://pubmed.ncbi.nlm.nih.gov/36329021
https://pubmed.ncbi.nlm.nih.gov/36329021