Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Heike Biebermann"'
Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside
Autor:
Friederike Höpfner, Sarah Paisdzior, Nanina Reininghaus, Iqra Sohail, Patrick Scheerer, Paolo Annibale, Heike Biebermann, Peter Kühnen
Publikováno v:
Life, Vol 12, Iss 11, p 1793 (2022)
The melanocortin-4 receptor (MC4R) is critical for central satiety regulation, therefore presenting a potent target for pharmacological obesity treatment. Melanocortin-4 receptor mutations prevalently cause monogenetic obesity. A possibility of overc
Externí odkaz:
https://doaj.org/article/218dcd084531440ebfd1bd1414b422a9
Autor:
Nanina Reininghaus, Sarah Paisdzior, Friederike Höpfner, Sabine Jyrch, Cigdem Cetindag, Patrick Scheerer, Peter Kühnen, Heike Biebermann
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1119 (2022)
Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the MC4R are the most frequent monogenic cause for obesity. Due to increasing numbers of people with e
Externí odkaz:
https://doaj.org/article/10a240516e68451ba9dde78469024a26
Autor:
Nikolas Herrfurth, Anna-Lena Volckmar, Triinu Peters, Gunnar Kleinau, Anne Müller, Cigdem Cetindag, Laura Schonnop, Manuel Föcker, Astrid Dempfle, Stefan A. Wudy, Struan F. A. Grant, Thomas Reinehr, Diana L. Cousminer, Johannes Hebebrand, Heike Biebermann, Anke Hinney
Publikováno v:
BMC Pediatrics, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Variation in genes of the leptinergic-melanocortinergic system influence both body weight and height. Because short normal stature (SNS) is characterized by reduced body height, delayed maturation and leanness, allelic variation o
Externí odkaz:
https://doaj.org/article/2c96f42edfff4ac49c1930a38bac7a91
Autor:
Grazia Rutigliano, Julia Bräunig, Claudia Del Grande, Vittoria Carnicelli, Isabella Masci, Sergio Merlino, Gunnar Kleinau, Luca Tessieri, Simone Pardossi, Sarah Paisdzior, Liliana Dell’Osso, Heike Biebermann, Riccardo Zucchi
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background: The G protein–coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and modulates monoaminergic and glutamatergic neurotransmissions. TAAR1 is stimu
Externí odkaz:
https://doaj.org/article/989bc7fb399a41a7a39ed21ec5c2b2f9
Autor:
Nicolas Heyder, Gunnar Kleinau, Michal Szczepek, Dennis Kwiatkowski, David Speck, Lucia Soletto, José Miguel Cerdá-Reverter, Heiko Krude, Peter Kühnen, Heike Biebermann, Patrick Scheerer
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppre
Externí odkaz:
https://doaj.org/article/c6f24ae870f145b8a2c9a641fa877eeb
Autor:
Julia Bräunig, Stefan Mergler, Sabine Jyrch, Carolin S. Hoefig, Mark Rosowski, Jens Mittag, Heike Biebermann, Noushafarin Khajavi
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone metabolite. The profound pharmacological effects of 3-T1AM on energy metabolism and thermal homeostasis have raised interest to elucidate its signaling properties in tissues that pertain to
Externí odkaz:
https://doaj.org/article/6b4fa2fd5eb64453909708924b265e1a
Autor:
Julia Bräunig, Juliane Dinter, Carolin S. Höfig, Sarah Paisdzior, Michal Szczepek, Patrick Scheerer, Mark Rosowski, Jens Mittag, Gunnar Kleinau, Heike Biebermann
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Trace amine-associated receptors (TAARs) belong to the class A G-protein-coupled receptors (GPCR) and are evolutionary related to aminergic receptors. TAARs have been identified to mediate effects of trace amines. TAAR1 signaling is mainly mediated v
Externí odkaz:
https://doaj.org/article/f73267e48a994ae983ce02dd4053918f
Autor:
Jessica Mühlhaus, Juliane Dinter, Sabine Jyrch, Alexander Teumer, Simon F. Jacobi, Georg Homuth, Peter Kühnen, Susanna Wiegand, Annette Grüters, Henry Völzke, Klemens Raile, Gunnar Kleinau, Heiko Krude, Heike Biebermann
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Activation of trace amine-associated receptor 1 (TAAR1) in endocrine pancreas is involved in weight regulation and glucose homeostasis. The purpose of this study was the identification and characterization of potential TAAR1 variants in patients with
Externí odkaz:
https://doaj.org/article/70f71652672f496dac3d4a66943fb522
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
The decarboxylated and deiodinated thyroid hormone (TH) derivative, 3-iodothyronamine (3-T1AM), is suggested to be involved in energy metabolism and thermoregulation. G protein-coupled receptors (GPCRs) are known as the main targets for 3-T1AM; howev
Externí odkaz:
https://doaj.org/article/211da0dbf5794d49ab231f188cd4a783
Autor:
Gerd Krause, Gunnar Kleinau, Catherine L. Worth, Annika Kreuchwig, Heike Biebermann, Patrick Marcinkowski, Patrick Scheerer
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
The thyroid-stimulating hormone receptor (TSHR) is a member of the glycoprotein hormone receptors, a sub-group of class A G-protein-coupled receptors (GPCRs). TSHR and its endogenous ligand thyrotropin (TSH) are of essential importance for growth and
Externí odkaz:
https://doaj.org/article/22eed666193a4118b9f2f5b2628a3854