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Autor:
Marion-Gabriele Ott, Hans Martin, Dieter Hoelzer, Oliver G. Ottmann, Manuel Grez, Heike Bialek, Heike Merget-Millitzer, Reinhard Seger, Johann Peter Hossle, Nicole Brüggenolte
Publikováno v:
Journal of hematotherapystem cell research. 11(4)
As a single-gene defect in phagocytes, the X-linked form of chronic granulomatous disease (X-CGD) is a disorder potentially amenable to gene therapy by transfer of a functional copy of the gp91(phox) gene into hematopoietic stem cells (HSC). Although