Zobrazeno 1 - 10
of 314
pro vyhledávání: '"Heike Biebermann"'
Autor:
Larissa Anthofer, Philipp Gmach, Zeynep Cansu Uretmen Kagiali, Gunnar Kleinau, Jonas Rotter, Robert Opitz, Patrick Scheerer, Annette G. Beck-Sickinger, Philipp Wolf, Heike Biebermann, Ingo Bechmann, Peter Kühnen, Heiko Krude, Sarah Paisdzior
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7565 (2024)
The melanocortin-4 receptor (MC4R) is a key player in the hypothalamic leptin–melanocortin pathway that regulates satiety and hunger. MC4R belongs to the G protein-coupled receptors (GPCRs), which are known to form heterodimers with other membrane
Externí odkaz:
https://doaj.org/article/2964aa52c7284f949f6e5e974a754a48
Autor:
Lea Bauer, Jessica Edwards, Andreas Heil, Sharon Dewitt, Heike Biebermann, Daniel Aeschlimann, Vera Knäuper
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2329 (2024)
A wound healing model was developed to elucidate the role of mesenchymal-matrix-associated transglutaminase 2 (TG2) in keratinocyte re-epithelialisation. TG2 drives keratinocyte migratory responses by activation of disintegrin and metalloproteinase 1
Externí odkaz:
https://doaj.org/article/5cd7b81554ff42f1a7f5fb151fbc8e9d
Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside
Autor:
Friederike Höpfner, Sarah Paisdzior, Nanina Reininghaus, Iqra Sohail, Patrick Scheerer, Paolo Annibale, Heike Biebermann, Peter Kühnen
Publikováno v:
Life, Vol 12, Iss 11, p 1793 (2022)
The melanocortin-4 receptor (MC4R) is critical for central satiety regulation, therefore presenting a potent target for pharmacological obesity treatment. Melanocortin-4 receptor mutations prevalently cause monogenetic obesity. A possibility of overc
Externí odkaz:
https://doaj.org/article/218dcd084531440ebfd1bd1414b422a9
Autor:
Nanina Reininghaus, Sarah Paisdzior, Friederike Höpfner, Sabine Jyrch, Cigdem Cetindag, Patrick Scheerer, Peter Kühnen, Heike Biebermann
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1119 (2022)
Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the MC4R are the most frequent monogenic cause for obesity. Due to increasing numbers of people with e
Externí odkaz:
https://doaj.org/article/10a240516e68451ba9dde78469024a26
Autor:
Nikolas Herrfurth, Anna-Lena Volckmar, Triinu Peters, Gunnar Kleinau, Anne Müller, Cigdem Cetindag, Laura Schonnop, Manuel Föcker, Astrid Dempfle, Stefan A. Wudy, Struan F. A. Grant, Thomas Reinehr, Diana L. Cousminer, Johannes Hebebrand, Heike Biebermann, Anke Hinney
Publikováno v:
BMC Pediatrics, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Variation in genes of the leptinergic-melanocortinergic system influence both body weight and height. Because short normal stature (SNS) is characterized by reduced body height, delayed maturation and leanness, allelic variation o
Externí odkaz:
https://doaj.org/article/2c96f42edfff4ac49c1930a38bac7a91
Publikováno v:
BIOspektrum. 29:22-24
The leptin-melanocortin pathway is playing a pivotal role for central body weight regulation. The melanocortin 4 receptor (MC4R) is essential to induce satiety after activation by the endogenous ligands α-/β-melanocyte-stimulating hormone. The rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2970840f1db181362a8eed3de8b0de7
https://doi.org/10.1007/s12268-023-1895-x
https://doi.org/10.1007/s12268-023-1895-x
Autor:
Grazia Rutigliano, Julia Bräunig, Claudia Del Grande, Vittoria Carnicelli, Isabella Masci, Sergio Merlino, Gunnar Kleinau, Luca Tessieri, Simone Pardossi, Sarah Paisdzior, Liliana Dell’Osso, Heike Biebermann, Riccardo Zucchi
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background: The G protein–coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and modulates monoaminergic and glutamatergic neurotransmissions. TAAR1 is stimu
Externí odkaz:
https://doaj.org/article/989bc7fb399a41a7a39ed21ec5c2b2f9
Autor:
Nicolas Heyder, Gunnar Kleinau, Michal Szczepek, Dennis Kwiatkowski, David Speck, Lucia Soletto, José Miguel Cerdá-Reverter, Heiko Krude, Peter Kühnen, Heike Biebermann, Patrick Scheerer
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppre
Externí odkaz:
https://doaj.org/article/c6f24ae870f145b8a2c9a641fa877eeb
Autor:
Sarah Paisdzior, Ellen Knierim, Gunnar Kleinau, Heike Biebermann, Heiko Krude, Rachel Straussberg, Markus Schuelke
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5338 (2021)
The nuclear thyroid hormone receptors (THRs) are key mediators of thyroid hormone function on the cellular level via modulation of gene expression. Two different genes encode THRs (THRA and THRB), and are pleiotropically involved in development, meta
Externí odkaz:
https://doaj.org/article/3b66753322b942e6ac15620669ab42ff
Autor:
Sarah Paisdzior, Ioanna Maria Dimitriou, Paul Curtis Schöpe, Paolo Annibale, Patrick Scheerer, Heiko Krude, Martin J. Lohse, Heike Biebermann, Peter Kühnen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 4, p 1224 (2020)
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin−melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic ob
Externí odkaz:
https://doaj.org/article/4bd0a93b3bf74807b3fc322af8943346