Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Heike, Wollmann"'
Autor:
Brenda Y. Han, Michelle K. Y. Seah, Imogen R. Brooks, Delia H. P. Quek, Dominic R. Huxley, Chuan-Sheng Foo, Li Ting Lee, Heike Wollmann, Huili Guo, Daniel M. Messerschmidt, Ernesto Guccione
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
PRDM family members are transcriptional regulators involved in cell identity and fate determination. Here, the authors characterize PRDM10 and show that it functions to ensure global translation efficiency during early embryonic development.
Externí odkaz:
https://doaj.org/article/e7989e77dc6240d282d3dcdcea55b0b3
Autor:
Slim Mzoughi, Jia Yi Fong, David Papadopoli, Cheryl M. Koh, Laura Hulea, Paolo Pigini, Federico Di Tullio, Giuseppe Andreacchio, Michal Marek Hoppe, Heike Wollmann, Diana Low, Matias J. Caldez, Yanfen Peng, Denis Torre, Julia N. Zhao, Oro Uchenunu, Gabriele Varano, Corina-Mihaela Motofeanu, Manikandan Lakshmanan, Shun Xie Teo, Cheng Mun Wun, Giovanni Perini, Soo Yong Tan, Chee Bing Ong, Muthafar Al-Haddawi, Ravisankar Rajarethinam, Susan Swee-Shan Hue, Soon Thye Lim, Choon Kiat Ong, Dachuan Huang, Siok-Bian Ng, Emily Bernstein, Dan Hasson, Keng Boon Wee, Philipp Kaldis, Anand Jeyasekharan, David Dominguez-sola, Ivan Topisirovic, Ernesto Guccione
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which
Externí odkaz:
https://doaj.org/article/9df5fd5400ec47e98903d3b9c0b42cbb
Autor:
Jessica SY Ho, Federico Di Tullio, Megan Schwarz, Diana Low, Danny Incarnato, Florence Gay, Tommaso Tabaglio, JingXian Zhang, Heike Wollmann, Leilei Chen, Omer An, Tim Hon Man Chan, Alexander Hall Hickman, Simin Zheng, Vladimir Roudko, Sujun Chen, Alcida Karz, Musaddeque Ahmed, Housheng Hansen He, Benjamin D Greenbaum, Salvatore Oliviero, Michela Serresi, Gaetano Gargiulo, Karen M Mann, Eva Hernando, David Mulholland, Ivan Marazzi, Dave Keng Boon Wee, Ernesto Guccione
Publikováno v:
eLife, Vol 10 (2021)
High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To identify splicing factors important for prostate cancer (PCa) fitness, we performed pooled
Externí odkaz:
https://doaj.org/article/bb9c4ec7e7bc4cdb8d75d13a76778524
Autor:
Jin Rong Ow, Matias J Caldez, Gözde Zafer, Juat Chin Foo, Hong Yu Li, Soumita Ghosh, Heike Wollmann, Amaury Cazenave-Gassiot, Chee Bing Ong, Markus R Wenk, Weiping Han, Hyungwon Choi, Philipp Kaldis
Publikováno v:
eLife, Vol 9 (2020)
Cell cycle progression and lipid metabolism are well-coordinated processes required for proper cell proliferation. In liver diseases that arise from dysregulated lipid metabolism, hepatocyte proliferation is diminished. To study the outcome of CDK1 l
Externí odkaz:
https://doaj.org/article/800dcd51bf63414c82eae688da8bc038
Autor:
Matthew R Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K M van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyungwon Choi, Philipp Kaldis
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009084 (2020)
The liver possesses a remarkable regenerative capacity based partly on the ability of hepatocytes to re-enter the cell cycle and divide to replace damaged cells. This capability is substantially reduced upon chronic damage, but it is not clear if thi
Externí odkaz:
https://doaj.org/article/3ed9f26de6f54ab09444430784a848ca
Autor:
Heike Wollmann, Hume Stroud, Ramesh Yelagandula, Yoshiaki Tarutani, Danhua Jiang, Li Jing, Bhagyshree Jamge, Hidenori Takeuchi, Sarah Holec, Xin Nie, Tetsuji Kakutani, Steven E. Jacobsen, Frédéric Berger
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Gene bodies of vertebrates and flowering plants are occupied by the histone variant H3.3 and DNA methylation. The origin and significance of these profiles remain largely unknown. DNA methylation and H3.3 enrichment profiles over
Externí odkaz:
https://doaj.org/article/309b68733c864f8f9abc52d10f581c2f
Autor:
Heike Wollmann, David Papadopoli, Ravisankar Rajarethinam, Giovanni Perini, Michal Marek Hoppe, Laura Hulea, Soo Yong Tan, Emily Bernstein, Susan Swee Shan Hue, Choon Kiat Ong, Siok Bian Ng, Soon Thye Lim, Slim Mzoughi, Cheryl M. Koh, Ivan Topisirovic, Federico Di Tullio, Manikandan Lakshmanan, Corina Mihaela Motofeanu, Ernesto Guccione, Cheng Mun Wun, Oro Uchenunu, Chee Bing Ong, David Dominguez-Sola, Shun Xie Teo, Diana Low, Giuseppe Andreacchio, Gabriele Varano, Dachuan Huang, Muthafar Al-Haddawi, Paolo Pigini, Denis Torre, Y Peng, Anand D. Jeyasekharan, Julia N. Zhao, Philipp Kaldis, Jia Yi Fong, Matias J. Caldez, Keng Boon Wee, Dan Hasson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b27e8389575acb1df8f84872f6fa6a
http://link.springer.com/article/10.1038/s41467-020-17064-0
http://link.springer.com/article/10.1038/s41467-020-17064-0
Publikováno v:
Stem cell reports, 14(5), 818-827. Cell Press
Stem Cell Reports
Stem Cell Reports
Summary Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e231e12621e633341cbf491b003f6f
https://doi.org/10.1016/j.stemcr.2020.03.013
https://doi.org/10.1016/j.stemcr.2020.03.013
Autor:
Elisabeth Pfeiffenberger, Chandrahas Koumar Ratnacaram, Ernesto Guccione, Joel Heng Loong Tan, Radoslaw M. Sobota, Xavier Bisteau, Daniel M. Messerschmidt, Heike Wollmann, Philipp Kaldis, Jayantha Gunaratne, Sheena Wee, Joanna H.S. Lee, Diana Low, Nathan Palmer, S. Zakiah A. Talib
Publikováno v:
The Journal of cell biology, 218 (9
The Journal of Cell Biology
The Journal of Cell Biology
Palmer et al. identify NRF1 as a novel CDK2 interactor and substrate. This interaction was found to be important for the DNA-binding activity of NRF1. Their findings demonstrate that the loss of CDK2 expression impairs the regulation of NRF1 transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773736be05302fa890f7f57139b06865
https://doi.org/10.1083/jcb.201903125
https://doi.org/10.1083/jcb.201903125
Autor:
Tuan Zea Tan, Heike Wollmann, Rui Lan Huang, Jieru Ye, Vin Yee Chung, Ernesto Guccione, Ruby Yun-Ju Huang, Hung Cheng Lai, Dennis Kappei
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-15 (2019)
Communications Biology
Communications Biology
Cancer cells exhibit phenotypic plasticity during epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) involving intermediate states. To study genome-wide epigenetic remodeling associated with EMT plasticity, we int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce61b3a08a84559e4af8bdb920b6628
http://link.springer.com/article/10.1038/s42003-019-0506-3
http://link.springer.com/article/10.1038/s42003-019-0506-3