TGF-β1 and TNF-α differentially regulate Twist1 mediated resistance towards BRAF/MEK inhibition in melanoma

Autor: Johanna M. Brandner, Heike Knausz, Johanne Lade-Keller, Shripad Joshi, Helmut Schaider, Christian Wels, Ehsan Bonyadi Rad, Dinoop Ravindran Menon

Publikováno v: Menon, D R, Wels, C, Bonyadi Rad, E, Joshi, S, Knausz, H, Lade-Keller, J, Brandner, J M & Schaider, H 2013, ' TGF-β1 and TNF-α differentially regulate Twist1 mediated resistance towards BRAF/MEK inhibition in melanoma ', Pigment Cell & Melanoma Research, vol. 26, no. 6, pp. 912-6 . https://doi.org/10.1111/pcmr.12139

Summary: Resistance to BRAF and MEK inhibition is a common phenomenon in melanoma. Cytokines and transcription factors have been attributed to contribute to the loss of sensitivity towards these inhibitors. Here, we show that transforming growth fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35fbbda5507707446a30f8bb5a02246
https://doi.org/10.1111/pcmr.12139

Examination of survivin expression in 50 chordoma specimens--A histological and in vitro study

Autor: Elke V, Froehlich, Beate, Rinner, Alexander J A, Deutsch, Katharina, Meditz, Heike, Knausz, Katharina, Troppan, Susanne, Scheipl, Christine, Wibmer, Andreas, Leithner, Bernadette, Liegl, Birgit, Lohberger

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 33(5)

Chordomas mainly arise along the axial skeleton and are characterized by their slow but destructive growth. Prognosis and quality of life are poor because treatment options are mainly limited to surgery and radiotherapy. Survivin, a member of the apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13088ad732cf0ec96ed259f5f3b52245
https://pubmed.ncbi.nlm.nih.gov/25640185

Establishment and detailed functional and molecular genetic characterisation of a novel sacral chordoma cell line, MUG-Chor1

Autor: Karin Buerger, Karoly Szuhai, Beate Rinner, Andreas Leithner, Bernadette Liegl, Elke Verena Froehlich, Heike Knausz, Susanne Scheipl, Carina Fischer, Birgit Lohberger, Slave Trajanoski, Christian Guelly

Publikováno v: International Journal of Oncology, 40(2), 443-451

Chordomas are rare, low to intermediate grade malignant bone tumors of the axial skeleton. Current treatment options are limited to surgical procedures, as chordomas are largely resistant to conventional radiation and chemotherapy. Cell lines are val

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573e7c5a8466255291b42ed71f66c364
http://hdl.handle.net/1887/106097

A petrol ether extract of Onosma paniculatum Bur. & Franch. shows strong anti-proliferative activity and induces apoptosis in human cancer cell lines

Autor: Beate Rinner, Rudolf Bauer, Helmut Schaider, Thomas Efferth, Herbert Boechzelt, Heike Knausz, Nadine Kretschmer

Publikováno v: Planta Medica. 75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d29c8ac28aa9646da5f90d8be428b39
https://doi.org/10.1055/s-0029-1234570

Ccytosporone-B Induces NR4A1 Meditated Apoptosis In Aggressive Lymphoma Cells

Autor: Heike Knausz, Peter Neumeister, Beate Rinner, Christine Beham-Schmid, Alexander Deutsch, Werner Linkesch

Publikováno v: Blood. 116:467-467

Abstract 467 NR4A1 (also called Nur77, TR3, or NGFI-B) and NR4A3 (Nor-1 or Minor) are two of three members of the orphan nuclear hormone receptor (NR) family referred to as Nur77 family. For both NRs no physiological ligand has been identified. These

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6859edbf3cefdece19a0cf0848cc175d
https://doi.org/10.1182/blood.v116.21.467.467