Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Heike, Holthues"'
Autor:
Lydia Engel, Ute Frederiksen, Heike Holthues, Isabella Spiwoks-Becker, Rainer Spessert, Susanne Tippmann, Katja Schneider, Tanja Wolloscheck, Gabriele Spatkowski
Publikováno v:
Journal of Neurochemistry. 115:585-594
In mammals, the retina contains a clock system that oscillates independently of the master clock in the suprachiasmatic nucleus and allows the retina to anticipate and to adapt to the sustained daily changes in ambient illumination. Using a combinati
Autor:
Heike Holthues, Rudolf E. Leube, Oliver Rickes, Nils H. Rohleder, Sybille Zimmer, Rainer Spessert, Lin Bai, Lydia Engel
Publikováno v:
Brain Research. 1203:89-96
The photoreceptive retina and the non-photoreceptive pineal gland are components of the circadian and the melatonin forming system in mammals. To contribute to our understanding of the functional integrity of the circadian system and the melatonin fo
Publikováno v:
Journal of Neuroendocrinology. 19:952-957
The retinal photopigment melanopsin (Opn4) mediates photoentrainment of the circadian system. In the present study, seasonal regulation of the melanopsin gene was investigated in comparison with the arylalkylamine N-acetyltransferase (AA-NAT) gene as
Autor:
I. Schwerdtle, Lydia Engel, Heike Holthues, S. Gerhold, Rainer Spessert, V. Lorenzkowski, B.B.P. Gupta, Lutz Vollrath, B. Heinrich
Publikováno v:
Neuroscience. 132:511-518
As the physiological role of fos-related antigen-2 (Fra-2) is largely unknown and since the pineal plays an important role in the photoperiodic control of the body, we have tested the hypothesis that Fra-2 expression is photoperiod-dependent and may
Publikováno v:
Biochemical and Biophysical Research Communications. 326:160-165
The directly light-sensitive chick pineal gland contains at least two photopigments. Pinopsin seems to mediate the acute inhibitory effect of light on melatonin synthesis, whereas melanopsin may act by phase-shifting the intrapineal circadian clock.
Publikováno v:
Brain research. 1376
Phosphodiesterase10A (PDE10A) is a dual specific cyclic nucleotide phosphodiesterase that is specifically enriched in striatum and which has gained attention as a therapeutic target for psychiatric disorders. The present study shows that PDE10A is al
Autor:
Katja, Schneider, Susanne, Tippmann, Isabella, Spiwoks-Becker, Heike, Holthues, Tanja, Wolloscheck, Gabriele, Spatkowski, Lydia, Engel, Ute, Frederiksen, Rainer, Spessert
Publikováno v:
Journal of neurochemistry. 115(3)
In mammals, the retina contains a clock system that oscillates independently of the master clock in the suprachiasmatic nucleus and allows the retina to anticipate and to adapt to the sustained daily changes in ambient illumination. Using a combinati
Publikováno v:
Journal of Microcolumn Separations. 4:431-438
Inorganic ions can be analyzed in small volumes using micro-liquid chromatography (micro-LC) and capillary zone electrophoresis (CE). Results for the analysis of alkali, alkaline earth, and ammonium cations as well as the main organic and inorganic a
Autor:
Iris Sound, Said A. Ibrahim, A. M. Hammam, Dina M. Fouad, Wolfram Baumann, Ursula Pfeifer-Fukumura, Heike Holthues
Publikováno v:
Zeitschrift fur Naturforschung. C, Journal of biosciences. 61(3-4)
An indirect format enzyme-linked immuno-sorbent assay (ELISA) on graphite rods (Ø 0.8 mm x 20 mm) and, for comparison, on microtiter plates has been developed against terbuthylazine. For this purpose, a series of 2-aminoalkyl-4-chloro-6-terbuthyl-s-
Publikováno v:
Journal of immunological methods. 304(1-2)
A series of new heterologous haptens has been synthesized and used as coating haptens in an antigen-immobilized immunoassay with a monoclonal antibody against atrazine. Coating was achieved by covalently linking the different haptens to a glutaraldeh