Impact of first-line use of caplacizumab on treatment outcomes in immune thrombotic thrombocytopenic purpura

Autor: Linus A. Völker, Jessica Kaufeld, Gesa Balduin, Lena Merkel, Lucas Kühne, Dennis A. Eichenauer, Thomas Osterholt, Holger Hägele, Martin Kann, Franziska Grundmann, Benedikt Kolbrink, Kevin Schulte, Anja Gäckler, Andreas Kribben, Kristina Boss, Sebastian A. Potthoff, Lars C. Rump, Tilman Schmidt, Anja S. Mühlfeld, Karsten Schulmann, Matthias Hermann, Jens Gaedeke, Kristin Sauerland, Jörn Bramstedt, Ulrich P. Hinkel, Wolfgang Miesbach, Frederic Bauer, Timm H. Westhoff, Heike Bruck, Veronika Buxhofer-Ausch, Tobias J. Müller, Ralph Wendt, Ana Harth, Adrian Schreiber, Evelyn Seelow, Markus Tölle, Christopher Gohlisch, Markus Bieringer, Gesa Geuther, Wolfram J. Jabs, Michael Fischereder, Anke von Bergwelt-Baildon, Ulf Schönermarck, Paul Knoebl, Jan Menne, Paul T. Brinkkoetter, Fedai Özcan, Silke Markau, Matthias Girndt, Helmut Felten, Martin Hausberg, Marcus Brand, Jens Gerth, Martin Bommer, Stefan Zschiedrich, Johanna Schneider, Saban Elitok, Alexander Gawlik, Vedat Schwenger, Maximilian Roeder, Jörg Radermacher, Anke Morgner, Regina Herbst, Charis von Auer

Publikováno v: Journal of Thrombosis and Haemostasis. 21:559-572

BACKGROUND: The von Willebrand factor-directed nanobody caplacizumab has greatly changed the treatment of immune thrombotic thrombocytopenic purpura (iTTP) in recent years. Data from randomized controlled trials established efficacy and safety. OBJEC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eab16496bb47c27f67f0167cb5337e3
https://doi.org/10.1016/j.jtha.2022.11.010

Associations of Smoking with Alterations in Renal Hemodynamics May Depend on Sex- Investigations in Potential Kidney Donors

Autor: Hana Guberina, Marcus Baumann, Heike Bruck, Thorsten Feldkamp, Jens Nürnberger, Andreas Kribben, Thomas Philipp, Oliver Witzke, Georgios Sotiropoulos, Anna Mitchell

Publikováno v: Kidney & Blood Pressure Research, Vol 37, Iss 6, Pp 611-621 (2013)

Background/Aims: Cigarette smoking is a risk factor for renal damage, but little is known about subclinical effects of smoking on renal hemodynamics and parameters of renal function in humans. We examined the associations of smoking with systemic and

Externí odkaz: https://doaj.org/article/d6c6a3f13ad640839074b6b395e02f65

Cardiac Adrenoceptors: Physiological and Pathophysiological Relevance

Autor: Otto-Erich Brodde, Heike Bruck, Kirsten Leineweber

Publikováno v: Journal of Pharmacological Sciences, Vol 100, Iss 5, Pp 323-337 (2006)

Abstract.: At present, nine adrenoceptor (AR) subtypes have been identified: α1A-, α1B-, α1D-, α2A-, α2B-, α2C-, β1-, β2-, and β3AR. In the human heart, β1- and β2AR are the most powerful physiologic mechanism to acutely increase cardiac p

Externí odkaz: https://doaj.org/article/159b50c0b1164c59ad9ade722fcf0d80

Physical, cognitive and emotional factors contributing to quality of life, functional health and participation in community dwelling in chronic kidney disease.

Autor: Ulla K Seidel, Janine Gronewold, Michaela Volsek, Olga Todica, Andreas Kribben, Heike Bruck, Dirk M Hermann

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91176 (2014)

Quality of life (QoL) impairment is a well-known consequence of chronic kidney disease (CKD). The factors influencing QoL and late life functional health are poorly examined.Using questionnaires combined with neuropsychological examinations, we prosp

Externí odkaz: https://doaj.org/article/f2e398399985408991889ce82d056cbf

Prevention of vascular calcification by the endogenous chromogranin A-derived mediator that inhibits osteogenic transdifferentiation

Autor: Walter Zidek, Danilo Fliser, Àngel Argilés, Heike Bruck, Christoph Kuppe, Heidi Noels, Setareh Orth-Alampour, Nikolaus Marx, Vera Jankowski, Shruti Bhargava, Nathalie Gayrard, Joseph Loscalzo, Zhuojun Wu, Cécile Notarnicola, Bernard Jover, Emiel P. C. van der Vorst, Silvia Salem, Michael Wolf, Wendy Theelen, Claudia Goettsch, Joachim Jankowski

Publikováno v: Basic Research in Cardiology
Basic Research in Cardiology, Springer Verlag, 2021, 116 (1), pp.57. ⟨10.1007/s00395-021-00899-z⟩
Basic Research in Cardiology, 116(1):57. Springer

The adrenal glands participate in cardiovascular (CV) physiology and the pathophysiology of CV diseases through their effects on sodium and water metabolism, vascular tone and cardiac function. In the present study, we identified a new adrenal compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0cbdb41b35e51c9bc0b7f5218fd742
https://hal.archives-ouvertes.fr/hal-03380227