Výsledky vyhledávání - "Heidrun Engler"

Characterization of Hemodynamic Events Following Intravascular Infusion of Recombinant Adenovirus Reveals Possible Solutions for Mitigating Cardiovascular Responses

Autor: Beth Hutchins, Vellekamp Gary J, Suganto Sutjipto, Todd Machemer, Heidrun Engler, Drake LaFace, Elena Brin, Susan Cannon-Carlson, Douglas Cornell, Mark Horn, Marcio Voloch, Thomas Schluep, Van Tsai, Nico van Rooijen, Dan Maneval, Shu Fen Wen, Seoju Lee, Sundari Ravindran

Publikováno v: Molecular Therapy. 12:254-263

Intravascular administration of recombinant adenovirus (rAd) in cancer patients has been well tolerated. However, dose-limiting hemodynamic responses associated with suppression of cardiac output have been observed at doses of 7.5 x 10(13) particles.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3a5c8f5ba2a07beebcf79024370c4a
https://doi.org/10.1016/j.ymthe.2005.03.007

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Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-α

Autor: Van Tsai, Heidrun Engler, Murali Ramachandra, Todd Machemer, Erlinda Quijano, Robert O. Ralston, Jennifer Philopena, Shu-Fen Wen

Publikováno v: Virology. 328(1):52-61

Replication competent adenoviruses with various E1 modifications designed to restrict their replication to tumor cells are being evaluated as oncolytic agents in clinical trials. In mouse models, we observed that such oncolytic adenoviruses showed gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ade00da62296166452f785176a1dbe

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Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer

Autor: Heidrun Engler, William F. Benedict, Jain Hua Zhou, Bogdan Czerniak, Colin P.N. Dinney, Daniel C. Maneval, Takashi Karashima, Charles J. Rosser, Robert J. Connor, Xin Qiao Zhang, Motoyuki Yamashita

Publikováno v: Cancer Gene Therapy. 9:687-691

Using our model to grow superficial human bladder cancer in the mouse bladder, we have found that the polyamide compound, Syn3, when injected intravesically for 1 hour at 1 mg/mL on two consecutive days, markedly increases rAd-beta-gal intravesical g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114843622bd74e47f3821d9f732417a0
https://doi.org/10.1038/sj.cgt.7700488

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Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy

Autor: Heidrun Engler, Mei Vaillancourt, John A. Howe, Duane E. Johnson, Paul W. Shabram, Aihua Zou, Murali Ramachandra, Amena Rahman, Barry J. Sugarman, Douglas Antelman, G. William Demers

Publikováno v: Nature Biotechnology. 19:1035-1041

Replicating adenoviruses may prove to be effective anticancer agents if they can be engineered to selectively destroy tumor cells. We have constructed a virus (01/PEME) containing a novel regulatory circuit in which p53-dependent expression of an ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6729284ce70eb2b95352a4564e96ef8
https://doi.org/10.1038/nbt1101-1035

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Interferon α2b gene delivery using adenoviral vector causes inhibition of tumor growth in xenograft models from a variety of cancers

Autor: Barry J. Sugarman, John A. Howe, Machemer T, Nodelman M, Daniel C. Maneval, Demers Gw, Shu Fen Wen, Nagabhushan Tl, Wills Ken N, Duane E. Johnson, Heidrun Engler, Shinoda J, Beltran J, Iqbal Ahmed Cm

Publikováno v: Cancer Gene Therapy. 8:788-795

A recombinant adenovirus expressing human interferon alpha2b driven by the cytomegalovirus promoter, IACB, was shown to produce and secrete biologically active protein in vitro and in vivo. Intravenous administration of IACB in Buffalo rats resulted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9357dd595e3e4ab81a6503c0e23ab84
https://doi.org/10.1038/sj.cgt.7700364

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Sustained intravesical interferon protein exposure is achieved using an adenoviral-mediated gene delivery system: a study in rats evaluating dosing regimens

Autor: Daniel C. Maneval, Robert J. Connor, Heidrun Engler, Todd Machemer, Jennifer M. Anderson

Publikováno v: Urology. 66(1)

Objectives To evaluate whether a recombinant replication-deficient adenovirus containing the secreted human interferon alpha-2b gene (rAd-IFN) could improve the tissue and urine levels of IFN protein by transducing the urothelium with the secreted hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9e41a375de26763a66c919d0b384a5
https://pubmed.ncbi.nlm.nih.gov/15992886

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Cyclodextrin-modified polyethylenimine polymers for gene delivery

Autor: Suzie H. Pun, Nathalie C. Bellocq, Thomas Schluep, Greg Jensen, Todd Machemer, Erlinda Quijano, Jeremy D. Heidel, Shu-Fen Wen, Heidrun Engler, Mark E. Davis, Aijie Liu

Publikováno v: Bioconjugate chemistry. 15(4)

Linear and branched poly(ethylenimines), lPEI and bPEI, respectively, grafted with beta-cyclodextrin are prepared to give CD-lPEI and CD-bPEI, respectively, and are investigated as in vitro and in vivo nonviral gene delivery agents. The in vitro toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c193284fa516872f7e1be7a1dec4b419
https://pubmed.ncbi.nlm.nih.gov/15264871

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Pharmacologic indicators of antitumor efficacy for oncolytic virotherapy

Autor: G William, Demers, Duane E, Johnson, Van, Tsai, Shu-Fen, Wen, Erlinda, Quijano, Todd, Machemer, Jennifer, Philopena, Murali, Ramachandra, John A, Howe, Paul, Shabram, Robert, Ralston, Heidrun, Engler

Publikováno v: Cancer research. 63(14)

Central to the development of oncolytic virotherapies for cancer will be a better understanding of the parameters that influence the outcome of virotherapy to treat disseminated cancer by i.v. administration versus regional disease by local treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83592a1a8cdfa15617cde3e3c27d355d
https://pubmed.ncbi.nlm.nih.gov/12873998

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Development of a formulation that enhances gene expression and efficacy following intraperitoneal administration in rabbits and mice

Autor: Thomas Schluep, Maneval Daniel, Alexis E Harper, Shu-Fen Wen, Todd Machemer, Susan E. Conroy, Erlinda Quijano, Heidrun Engler, Ken N. Wills

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 7(4)

We conducted a series of experiments to determine if intraperitoneal (IP) delivery of recombinant adenovirus (rAd)-based therapies is improved through carrier vehicle selection, and compared an icodextrin solution (a high molecular weight dextrin wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ef2ff43f12b0960737642630d6c0dc
https://pubmed.ncbi.nlm.nih.gov/12727120

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Successful adenovirus-mediated wild-type p53 gene transfer in patients with bladder cancer by intravesical vector instillation

Autor: Daniel C. Maneval, Christoph Huber, Jürgen Kuball, Derek Atkins, Grace Michael, Erlinda Quijano, Joachim W. Thüroff, Heidrun Engler, Mary Ann Fritz, Shu Fen Wen, Joachim Leissner, Beth Hutchins, S. Störkel, Patricia Meinhardt, Martin Schuler

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 20(4)

PURPOSE: To study safety, feasibility, and biologic activity of adenovirus-mediated p53 gene transfer in patients with bladder cancer. PATIENTS AND METHODS: Twelve patients with histologically confirmed bladder cancer scheduled for cystectomy were tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c8a7f93c94054ff4015a53da35a757
https://pubmed.ncbi.nlm.nih.gov/11844817

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