Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Heidi W S Wong"'
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47447 (2012)
The spindle assembly checkpoint is crucial for the maintenance of a stable chromosome number. Defects in the checkpoint lead to Chromosomal INstability (CIN), which is linked to the progression of tumors with poor clinical outcomes such as drug resis
Externí odkaz:
https://doaj.org/article/f64353e28f654ddd994fa0b5a4be267d
Publikováno v:
Journal of Evolutionary Biology. 33:189-201
Maternal inheritance of mitochondrial DNA (mtDNA) was originally thought to prevent any response to selection on male phenotypic variation attributable to mtDNA, resulting in a male-biased mtDNA mutation load ("mother's curse"). However, the theory u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789090b5386d1991519a1d9824164577
https://doi.org/10.1111/jeb.13561
https://doi.org/10.1111/jeb.13561
Publikováno v:
Proc Biol Sci
Assuming that fathers never transmit mitochondrial DNA (mtDNA) to their offspring, mitochondrial mutations that affect male fitness are invisible to direct selection on males, leading to an accumulation of male-harming alleles in the mitochondrial ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89423b8bcb879912c54ba735fa28a013
https://europepmc.org/articles/PMC7423468/
https://europepmc.org/articles/PMC7423468/
Autor:
Heidi W. S. Wong, Luke Holman
Publikováno v:
Journal of evolutionary biologyREFERENCES. 33(1)
Segregation distorters are selfish genetic elements that subvert Mendelian inheritance, often by destroying gametes that do not carry the distorter. Simple theoretical models predict that distorter alleles will either spread to fixation or stabilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12b4c04dff5298383ab03538301167f
https://pubmed.ncbi.nlm.nih.gov/31605400
https://pubmed.ncbi.nlm.nih.gov/31605400
Publikováno v:
Cell Cycle. 13:622-631
Chromosomal instability (CIN), as a common feature of tumors, represents a potential therapeutic target if ways can be found to specifically cause apoptosis in unstably dividing cells. We have previously shown that if signaling through the JNK pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32cee64fc284ee5e66e609dc471ae7b
https://doi.org/10.4161/cc.27484
https://doi.org/10.4161/cc.27484
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e47447 (2012)
PLoS ONE, Vol 7, Iss 10, p e47447 (2012)
Background: The spindle assembly checkpoint is crucial for the maintenance of a stable chromosome number. Defects in the checkpoint lead to Chromosomal INstability (CIN), which is linked to the progression of tumors with poor clinical outcomes such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd67b2c9ee2eebd3d198af49e0f11387
https://pubmed.ncbi.nlm.nih.gov/23077619
https://pubmed.ncbi.nlm.nih.gov/23077619