Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Heidi Trusheim"'
Autor:
Heidi Peck, Karen L. Laurie, Steve Rockman, Vivian Leung, Hilda Lau, Sally Soppe, Cleve Rynehart, Chantal Baas, Heidi Trusheim, Ian G. Barr
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Influenza vaccines are utilised to combat seasonal and pandemic influenza. The key to influenza vaccination currently is the availability of candidate vaccine viruses (CVVs). Ideally, CVVs reflect the antigenic characteristics of the circula
Externí odkaz:
https://doaj.org/article/b461dbcec784444e92483c2eea786e20
Autor:
Bernhard Roth, Takato Odagiri, Norio Yamamoto, Masato Tashiro, Heidi Trusheim, Teruko Ogane, Katsumi Mizuta, Hitoshi Takahashi, Asumi Hirata-Saito, Yuichi Harada
Publikováno v:
Influenza and Other Respiratory Viruses
Background: Cell-based influenza vaccines can solve the problem of the frequent occurrence of egg adaptation-associated antigenic changes observed in egg-based vaccines Seed viruses for cell-based vaccines can be prepared from clinical specimens by c
Autor:
Asumi Hirata-Saito, Kazuya Nakamura, Nami Konomi, Itsuki Hamamoto, Hideki Asanuma, Takato Odagiri, Norio Yamamoto, Yuichi Harada, Katsumi Mizuta, Roth Bernhard, Hitoshi Takahashi, Yasushi Konomi, Teruko Ogane, Masato Tashiro, Heidi Trusheim
Publikováno v:
Vaccine. 37:6526-6534
Suspension Madin-Darby canine kidney (MDCK) cells (MDCK-N), adherent MDCK cells (MDCK-C), and adherent rhesus monkey kidney LLC-MK2 cells (LLC-MK2D) were systematically evaluated for the preparation of influenza vaccine seed viruses for humans on the
Autor:
John W. McCauley, Takato Odagiri, Ian G. Barr, Jacqueline M. Katz, David E. Wentworth, Theodore Tsai, Ruben O. Donis, Heidi Trusheim
Publikováno v:
npj Vaccines, Vol 3, Iss 1, Pp 1-5 (2018)
NPJ Vaccines
NPJ Vaccines
The 2017–2018 seasonal influenza epidemics were severe in the US and Australia where the A(H3N2) subtype viruses predominated. Although circulating A(H3N2) viruses did not differ antigenically from that recommended by the WHO for vaccine production
Autor:
Tony Colegate, Othmar G. Engelhardt, Theodore F. Tsai, Otfried Kistner, John Wood, Keishin Sugawara, Jeroen Medema, J.G.M. Heldens, Richard Schwartz, Jonathan S.B. Smith, Heidi Trusheim, Yoichiro Kino, Philip D. Minor, Luc Fabry, Ryoko Krause, Ronald Kompier, David Ryan, James S. Robertson, Shigetaka Mimori, Keiichi Makizumi, Simone Blayer
Publikováno v:
Vaccine. 27:2907-2913
A meeting was held at NIBSC, UK in July 2007 to discuss the implications of progress in the use of cell culture systems for the manufacture of vaccines against influenza. Issues discussed included the effect of using eggs and different cell types in
Autor:
Boran Altincicek, Sandip M. Kanse, Aya Shibamiya, Michael Niepmann, Klaus T. Preissner, Heidi Trusheim, Dietmar Linder, Eleni Tzima
Publikováno v:
Biochemical Journal. 394:687-692
FSAP (Factor VII-activating protease) is a novel plasma-derived serine protease that regulates haemostasis as well as vascular cell proliferation. FSAP undergoes autoactivation in the presence of polyanionic macromolecules such as heparin and RNA. Co
Publikováno v:
Annals of the New York Academy of Sciences. 921:242-250
Protein kinase B/Akt (PKB/Akt) is activated by phosphatidylinositol 3-kinase (PI 3-K) and is a central mediator of cellular proliferation and protection against apoptosis. Insulin, insulin-like growth factor (IGF-1), and glucagon-like peptide-1 (GLP-
Autor:
Lewis C. Cantley, Heidi Trusheim, David A. Fruman, Dieter Hörsch, Kohjiro Ueki, Katja Trümper, Daniel Hallmann, C. Ronald Kahn
Publikováno v:
Journal of Biological Chemistry. 278:5099-5108
The p85alpha regulatory subunit of class I(A) phosphoinositide 3-kinases (PI3K) is derived from the Pik3r1 gene, which also yields alternatively spliced variants p50alpha and p55alpha. It has been proposed that excess monomeric p85 competes with func
Autor:
Anja Knolle, Ruaidhrí J. Carmody, Alexandra Göke, Burkhard Göke, Rüdiger Göke, Youhai H. Chen, Harald Schmidt, Andreas Wilmen, Heidi Trusheim
Publikováno v:
Biochemical and Biophysical Research Communications. 297:78-82
To elucidate the molecular mechanisms of cell death, we have cloned a new gene, designated death-upregulated gene (DUG), from rat insulinoma cells. DUG is constitutively expressed at very low levels in normal cells but is dramatically upregulated in
Publikováno v:
Endocrinology. 140:624-631
The human glucagon-like peptide-1 (GLP-1) receptor mediates the insulinotropic effects of the incretin hormone GLP-1. It is expressed in a cell- and tissue-specific manner. Recently, we cloned the 5'-region of the GLP-1 receptor gene and found that t