Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Heidi Savage"'
1
Akademický článek
Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant
Autor: Jill M. Spoerke, Steven Gendreau, Kimberly Walter, Jiaheng Qiu, Timothy R. Wilson, Heidi Savage, Junko Aimi, Mika K. Derynck, Meng Chen, Iris T. Chan, Lukas C. Amler, Garret M. Hampton, Stephen Johnston, Ian Krop, Peter Schmid, Mark R. Lackner
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Fulvestrant degrades the oestrogen receptor. Here, the authors report on a clinical trial using fulvestrant and show that mutations in the oestrogen receptor alpha gene are prevalent in circulating tumour DNA and do not influence the clinical outcome
Externí odkaz: https://doaj.org/article/3ed6583a52b645a290a897ba20ac7a5f
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2
Akademický článek
Molecular biomarker analyses using circulating tumor cells.
Autor: Elizabeth A Punnoose, Siminder K Atwal, Jill M Spoerke, Heidi Savage, Ajay Pandita, Ru-Fang Yeh, Andrea Pirzkall, Bernard M Fine, Lukas C Amler, Daniel S Chen, Mark R Lackner
Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12517 (2010)
Evaluation of cancer biomarkers from blood could significantly enable biomarker assessment by providing a relatively non-invasive source of representative tumor material. Circulating Tumor Cells (CTCs) isolated from blood of metastatic cancer patient
Externí odkaz: https://doaj.org/article/f38c38ef1872463483198588d1a90475
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4
Data from Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer
Autor: Mark R. Lackner, Lukas C. Amler, Xiaolan Hu, Guy Cavet, Elizabeth Luis, Gail D. Lewis Phillips, Leanne Berry, Fiona Zhong, Ling-Yuh Huw, Heidi Savage, Carol O'Brien, Jiping Zha
The insulin-like growth factor-I receptor (IGF-IR) pathway is required for the maintenance of the transformed phenotype in neoplastic cells and hence has been the subject of intensive drug discovery efforts. A key aspect of successful clinical develo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e442f70eabbe3ad26b8a94c3d2280b
https://doi.org/10.1158/1535-7163.c.6532137.v1
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6
Data from Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays
Autor: Mark R. Lackner, Yibing Yan, Lukas Amler, Paul J. Fielder, Heidi Savage, Jill Spoerke, Carol O'Brien, Qun Jenny Wu, Zachary S. Boyd
Although breast cancer molecular subtypes have been extensively defined by means of gene expression profiling over the past decade, little is known, at the proteomic level, as to how signaling pathways are differentially activated and serve to contro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1807117f9680f541589c73220793c2fe
https://doi.org/10.1158/1535-7163.c.6531077.v1
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