Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Heidi S. Walton"'
Autor:
Timothy P. Dalton, Peter R. Sinclair, William J. Bement, Jacqueline F. Sinclair, Kerry L. Ross, Nadia Gorman, Richard S. Eisenstein, Juliana G. Szakacs, Daniel W. Nebert, Glenn S. Gerhard, Heidi S. Walton
Publikováno v:
Hepatology. 35:912-921
In mice treated with 5-aminolevulinic acid (ALA) and polyhalogenated aromatic compounds, the levels of both hepatic cytochrome P450 (CYP)1A2 and iron-which can be quite different among inbred strains-are critical in causing experimental uroporphyria.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::901b44a257149ff8740ee3a6f7d33ffd
https://doi.org/10.1053/jhep.2002.32487
https://doi.org/10.1053/jhep.2002.32487
Autor:
Nancy C. Andrews, Heidi S. Walton, Joanne E. Levy, Juliana G. Szakacs, Jacqueline F. Sinclair, Nadia Gorman, Glenn S. Gerhard, Peter R. Sinclair, William J. Bement
Publikováno v:
Hepatology. 33:406-412
Porphyria cutanea tarda (PCT), a liver disease with skin lesions caused by excess liver production of uroporphyrin (URO), is associated with consumption of alcoholic beverages or estrogens, and moderate iron overload. Recently, it has been shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c23c14126f2d80e7da44c8cbc590a0
https://doi.org/10.1053/jhep.2001.21409
https://doi.org/10.1053/jhep.2001.21409
Autor:
Sheryl G. Wood, Elizabeth H. Jeffery, Jacqueline F. Sinclair, Heidi S. Walton, Peter R. Sinclair, Steven A. Wrighton, William J. Bement, Juliana G. Szakacs, Frank J. Gonzalez, Jenna L. Bement
Publikováno v:
Toxicology and Applied Pharmacology. 168:114-122
CYP2E1 has been reported to have an essential role in alcohol-mediated increases in hepatic steatosis and acetaminophen hepatotoxicity. We found that pretreatment of Cyp2e1(-/-) mice with ethanol plus isopentanol, the predominant alcohols in alcoholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa89495557a56faa6d7a6bbd727a39d8
https://doi.org/10.1006/taap.2000.9023
https://doi.org/10.1006/taap.2000.9023
Publikováno v:
Archives of Biochemistry and Biophysics. 371:8-14
We had previously reported that low concentrations of sodium arsenite (1-5 microM) decreased the induction of cytochrome P450 CYP1A and CYP2H in cultured chick embryo hepatocytes in parallel with increases in heme oxygenase. However, in those studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6dd8904e945d9042414c3d9ceb6b32f
https://doi.org/10.1006/abbi.1999.1416
https://doi.org/10.1006/abbi.1999.1416
Publikováno v:
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 121:405-412
Uroporphyrin (URO) accumulation in the liver of animals treated with polyhalogenated aromatic hydrocarbons (PHAH) is associated with increased microsomal oxidation of uroporphyrinogen catalyzed by rodent CYP1A2 and by a similar form in chicken, CYP1A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207a2269bc1fd32be9c52d72fa2baa51
https://doi.org/10.1016/s0742-8413(98)10059-2
https://doi.org/10.1016/s0742-8413(98)10059-2
Autor:
Judith M. Jacobs, Maurice Roberts, Robert R. Roussel, Jacqueline F. Sinclair, Barney E. Dwyer, Peter R. Sinclair, Sheryl G. Wood, Doreen Marek, Heidi S. Walton
Publikováno v:
Toxicology and Applied Pharmacology. 150:376-382
In earlier studies, treatment with sodium arsenite was shown to decrease total hepatic CYP in rats. A concomitant increase in heme oxygenase, the rate-limiting step in heme degradation to biliverdin, was considered responsible for the decrease in CYP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43397f3527593e3e8b5ff1fbc5befc95
https://doi.org/10.1006/taap.1998.8436
https://doi.org/10.1006/taap.1998.8436
Autor:
Jacqueline F. Sinclair, Heidi S. Walton, Sheryl G. Wood, Judith M. Jacobs, Calen Nichols, Nadia Gorman, Peter R. Sinclair
Publikováno v:
Toxicology. 125:95-105
The formation of zinc protoporphyrin in response to lead or iron depletion has previously been investigated in erythroid systems. Because of its possible metabolic role in non-erythroid tissue, we investigated the formation of zinc protoporphyrin in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc46807e924278add93d8eac761f80fc
https://doi.org/10.1016/s0300-483x(97)00164-9
https://doi.org/10.1016/s0300-483x(97)00164-9
Publikováno v:
Toxicology and Applied Pharmacology. 147:171-179
Uroporphyrin (URO) accumulation occurs in chick embryo hepatocytes treated with a number of polyhalogenated aromatic hydrocarbons (PHAHs) that are known inducers of cytochrome P4501As (CYP1A). Previous dose response studies had shown that URO accumul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb70b0acd8846cab30a747c362bea84
https://doi.org/10.1006/taap.1997.8273
https://doi.org/10.1006/taap.1997.8273
Autor:
Peter R. Sinclair, Jacqueline F. Sinclair, Nadia Gorman, Heidi S. Walton, Richard W. Lambrecht, William J. Bement
Publikováno v:
Hepatology. 22:565-572
Ascorbate was previously shown to suppress accumulation of uroporphyrin (URO) in cultured chick embryo hepatocytes and to competitively inhibit microsomal oxidation of uroporphyrinogen catalyzed by cytochrome P4501A2. Here we used the Osteogenic Diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2d0908cba4079d23967bcd28aed1149
https://doi.org/10.1002/hep.1840220229
https://doi.org/10.1002/hep.1840220229
Autor:
Nadia, Gorman, Kerry L, Ross, Heidi S, Walton, William J, Bement, Juliana G, Szakacs, Glenn S, Gerhard, Timothy P, Dalton, Daniel W, Nebert, Richard S, Eisenstein, Jacqueline F, Sinclair, Peter R, Sinclair
Publikováno v:
Hepatology (Baltimore, Md.). 35(4)
In mice treated with 5-aminolevulinic acid (ALA) and polyhalogenated aromatic compounds, the levels of both hepatic cytochrome P450 (CYP)1A2 and iron-which can be quite different among inbred strains-are critical in causing experimental uroporphyria.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c858578ac92d1ba685165c285c65dca
https://pubmed.ncbi.nlm.nih.gov/11915039
https://pubmed.ncbi.nlm.nih.gov/11915039