Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Heidi S. Trask"'
Autor:
Jacqueline F. Sinclair, Peter R. Sinclair, Nadia Gorman, Susan W. Robinson, Glenn S. Gerhard, Andrew G. Smith, Heidi S. Trask
Publikováno v:
Toxicology and Applied Pharmacology. 221:235-242
Hexachlorobenzene (HCB), a weak ligand of the aryl hydrocarbon receptor (AHR), causes hepatic uroporphyrin (URO) accumulation (uroporphyria) in humans and animals. CYP1A2 has been shown to be necessary in the development of uroporphyria in mice. Usin
Autor:
Judith M. Jacobs, Jacqueline F. Sinclair, Dominic J. Balestra, Nicholas J. Jacobs, Heidi S. Trask, Peter R. Sinclair, Juliana G. Szakacs, Adrian Zaharia, Nadia Gorman
Publikováno v:
Hepatology (Baltimore, Md.). 46(6)
Porphyria cutanea tarda is a liver disease characterized by elevated hepatic iron and excessive production of uroporphyrin (URO). Phlebotomy is an effective treatment that probably acts by reducing hepatic iron. Here we used Hfe(−/−) mice to comp