Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Heidi S Phillips"'
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
PDF file - 55K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc838fa47a9d23267b37a858ed4d3f8
https://doi.org/10.1158/1078-0432.22447710
https://doi.org/10.1158/1078-0432.22447710
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
PDF file - 77K, Cell viability following treatment with GNE-317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b14e8b2c62065f86e47c21ee5d4697a
https://doi.org/10.1158/1078-0432.22447713.v1
https://doi.org/10.1158/1078-0432.22447713.v1
Autor:
Frank Winkler, Wolfgang Wick, Heidi S. Phillips, Jeffrey J. Wallin, Laurent Salphati, Anna S. Berghoff, Miriam Gömmel, Gergely Solecki, Yunxiang Liao, Jonas Blaes, Matthias Osswald
Purpose: The role of blood–brain barrier (BBB) integrity for brain tumor biology and therapy is a matter of debate.Experimental Design: We developed a new experimental approach using in vivo two-photon imaging of mouse brain metastases originating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9013f18f09085c031a94db5fe07ab6
https://doi.org/10.1158/1078-0432.c.6527139
https://doi.org/10.1158/1078-0432.c.6527139
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
PDF file - 60K, Plasma Concentrations, Brain Concentrations and Brain-to-Plasma Ratio Measured at the End of Study (42 days) 2 hours Following the Last Daily PO Administration of GNE-317 (40 mg/kg), GDC-0941 (250 mg/kg) or GDC-0980 (10 mg/kg) to GS2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1649707918904ad8cbd83771a80366bc
https://doi.org/10.1158/1078-0432.22447701
https://doi.org/10.1158/1078-0432.22447701
Autor:
Frank Winkler, Wolfgang Wick, Heidi S. Phillips, Jeffrey J. Wallin, Laurent Salphati, Anna S. Berghoff, Miriam Gömmel, Gergely Solecki, Yunxiang Liao, Jonas Blaes, Matthias Osswald
A, Metastasis sizes in the different treatment groups at start of treatment (p=0.596, ANOVA on Ranks). B, Quantifications of the mean grey values of the sodium fluorescein signal, normalized to background signal. Note that all metastases could clearl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6af80bb91ef3270129c76c98c2b52c
https://doi.org/10.1158/1078-0432.22469088
https://doi.org/10.1158/1078-0432.22469088
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
PDF file - 116K, Plot of CNS-MPO score vs. efflux ratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec1963a4dc8dbcd09c67292559efb78
https://doi.org/10.1158/1078-0432.22447716.v1
https://doi.org/10.1158/1078-0432.22447716.v1
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
PDF file - 57K, Selectivity of GNE-317 against a Panel of 59 Kinases. GNE-317 was Tested at 1 �M in the Invitrogen SelectScreen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29316f2a68ac338de6dc314e3ac4eb34
https://doi.org/10.1158/1078-0432.22447698.v1
https://doi.org/10.1158/1078-0432.22447698.v1
Autor:
Frank Winkler, Wolfgang Wick, Heidi S. Phillips, Jeffrey J. Wallin, Laurent Salphati, Anna S. Berghoff, Miriam Gömmel, Gergely Solecki, Yunxiang Liao, Jonas Blaes, Matthias Osswald
A, In permeable (red line) vs. non-permeable (green line) brain metastases, the extravasation of sodium fluorescein was significantly different directly after i.v. sodium fluorescein injection, and at the end of the corresponding time series (n=7 per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f95ea7e78febd5748ffc13a1ec49374
https://doi.org/10.1158/1078-0432.22469091.v1
https://doi.org/10.1158/1078-0432.22469091.v1
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
PDF file - 47K, Anti-proliferative EC50's for GNE-317 against a Panel of Nine Glioma Cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927b2437f8d62a766f1d9f3c72bee192
https://doi.org/10.1158/1078-0432.22447695.v1
https://doi.org/10.1158/1078-0432.22447695.v1
Autor:
Heidi S. Phillips, Alan G. Olivero, Stephen E. Gould, Xiaolin Zhang, Jeffrey J. Wallin, Jann N. Sarkaria, Hani Bou Reslan, Jenny L. Pokorny, Emile G. Plise, Jodie Pang, Leslie B. Lee, Shari Lau, Hartmut Koeppen, Samir Kharbanda, Joan Greve, Kyle A. Edgar, Jonathan Cheong, Richard A. Carano, Kai Barck, Merry Nishimura, Bruno Alicke, Timothy P. Heffron, Laurent Salphati
Purpose: Glioblastoma (GBM), the most common primary brain tumor in adults, presents a high frequency of alteration in the PI3K pathway. Our objectives were to identify a dual PI3K/mTOR inhibitor optimized to cross the blood–brain barrier (BBB) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c07dac8b36b8db1529b9059f8f810bd
https://doi.org/10.1158/1078-0432.c.6521166.v1
https://doi.org/10.1158/1078-0432.c.6521166.v1