Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Heidi Rye Hudlebusch"'
Autor:
Kristian Helin, Guido Sauter, Mette Jørgensen, Jens Vilstrup Johansen, Henrik Holm Rossing, Elisabeth Ralfkiær, Ronald Simon, Eric Santoni-Rugiu, Heidi Rye Hudlebusch
Supplementary Figures S1-S4; Supplementary Tables S1-S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a2c5b1a9f2b4131d2caffc0bd78b75
https://doi.org/10.1158/1078-0432.22442583.v1
https://doi.org/10.1158/1078-0432.22442583.v1
Autor:
Kristian Helin, Guido Sauter, Mette Jørgensen, Jens Vilstrup Johansen, Henrik Holm Rossing, Elisabeth Ralfkiær, Ronald Simon, Eric Santoni-Rugiu, Heidi Rye Hudlebusch
Purpose: Multiple myeloma SET (Suppressor of variegation, Enhancer of zeste, and Trithorax) domain (MMSET) is a histone lysine methyltransferase deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation and poor prognosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fc12aec8de05e6c88e5490b9ed2612
https://doi.org/10.1158/1078-0432.c.6519273
https://doi.org/10.1158/1078-0432.c.6519273
Autor:
Marco Berrera, Marianne Lerbech Jensen, Martin Ebeling, Peter Hagedorn, Marianne R. Møller, Morten Lindow, Troels Koch, Henrik Frydenlund Hansen, Malene Pontoppidan, Heidi Rye Hudlebusch, Andreas Dieckmann, Tina S Bisgaard
Publikováno v:
Nucleic Acids Research
Hagedorn, P H, Pontoppidan, M, Bisgaard, T S, Berrera, M, Dieckmann, A, Ebeling, M, Møller, M R, Hudlebusch, H, Jensen, M L, Hansen, H F, Koch, T & Lindow, M 2018, ' Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice ', Nucleic Acids Research, vol. 46, no. 11, pp. 5366-5380 . https://doi.org/10.1093/nar/gky397
Hagedorn, P H, Pontoppidan, M, Bisgaard, T S, Berrera, M, Dieckmann, A, Ebeling, M, Møller, M R, Hudlebusch, H, Jensen, M L, Hansen, H F, Koch, T & Lindow, M 2018, ' Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice ', Nucleic Acids Research, vol. 46, no. 11, pp. 5366-5380 . https://doi.org/10.1093/nar/gky397
Antisense oligonucleotides that are dependent on RNase H for cleavage and subsequent degradation of complementary RNA are being developed as therapeutics. Besides the intended RNA target, such oligonucleotides may also cause degradation of unintended
Autor:
Ronald Simon, Maria Antonietta De Ioris, Lisa Leth Maroun, M Quarto, Henrik Daa Schrøder, Jens Vilstrup Johansen, Mette Rose Jørgensen, Eric Santoni-Rugiu, Kristian Helin, Guido Sauter, Zarah Glad Zimling, Bodil Laub Petersen, Julie Skotte, Michael Lees, Rossella Rota, Heidi Rye Hudlebusch, Catherine Rechnitzer
Publikováno v:
Hudlebusch, H R, Skotte, J, Santoni-Rugiu, E, Zimling, Z G, Lees, M J, Simon, R, Sauter, G, Rota, R, De Ioris, M A, Quarto, M, Johansen, J V, Jørgensen, M, Rechnitzer, C M A, Maroun, L L, Schrøder, H, Petersen, B L & Helin, K 2011, ' MMSET is highly expressed and associated with aggressiveness in neuroblastoma ', Cancer Research, vol. 71, no. 12, pp. 4226-35 . https://doi.org/10.1158/0008-5472.CAN-10-3810
MMSET (WHSC1/NSD2) is a SET domain–containing histone lysine methyltransferase the expression of which is deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation associated with poor prognosis. Recent studies have sho
Autor:
Heidi Rye Hudlebusch, Thomas Rasmussen, Marianne Lodahl, Kim Theilgaard-Mönch, Hans Erik Johnsen
Publikováno v:
University of Copenhagen
The frequently detected t(4;14)(p16.3;q32) translocation in multiple myeloma (MM) results in a dysregulation of two potential oncogenes: multiple myeloma SET domain (MMSET) and fibroblast growth factor receptor 3 (FGFR3). As the expression of FGFR3 i
Autor:
Kim Theilgaard-Mönch, Heidi Rye Hudlebusch, Hans Erik Johnsen, Marianne Lodahl, Inger Marie S. Dahl, Thomas Rasmussen
Publikováno v:
British Journal of Haematology. 123:253-262
This study investigated the expression pattern in primary plasma cells (PCs) of putative oncogenes suggested to be involved in multiple myeloma (MM) development. cDNA archives were generated by global reverse transcription polymerase chain reaction f
Autor:
Peter Birk, Heidi Rye Hudlebusch, Dorthe Vang Larsen, Kristian Helin, Lars-Ole Gerlach, Michael Lees, Marc Labelle, Jesper Morten Nielsen, Thomas Boesen, Bo Heinemann
Publikováno v:
Nature. 514:E1-E2
Arising from L. Kruidenier et al. 404–408 (2012); doi:10.1038/nature11262 The recent publication1 of the first highly potent and specific inhibitor GSK-J1/J4 of the H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A provides a potential tool compo
Publikováno v:
Leukemia & Lymphoma. 45:1215-1217
Multiple Myeloma (MM) is an incurable B-cell malignancy characterized by uncontrolled growth of plasma cells (PCs) in the bone marrow. The pathogenesis of MM is complex and still not fully understood. The HOX genes encode a family of homeodomain cont
Publikováno v:
British Journal of Haematology. 117:626-628
The t(4:14) translocation affects two potential oncogenes, FGFR3 and MMSET, in multiple myeloma (MM). We investigated the frequency of FGFR3 dysregulation and its prognostic value in MM. FGFR3 mRNA levels were determined in 110 diagnostic bone marrow
Autor:
Henrik H Rossing, Jens Vilstrup Johansen, Elisabeth Ralfkiaer, Eric Santoni-Rugiu, Ronald Simon, Mette Rose Jørgensen, Kristian Helin, Guido Sauter, Heidi Rye Hudlebusch
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 17(9)
Purpose: Multiple myeloma SET (Suppressor of variegation, Enhancer of zeste, and Trithorax) domain (MMSET) is a histone lysine methyltransferase deregulated in a subgroup of multiple myelomas with the t(4;14)(p16;q32) translocation and poor prognosis