Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Autor: Saedis, Saevarsdottir, Lilja, Stefansdottir, Patrick, Sulem, Gudmar, Thorleifsson, Egil, Ferkingstad, Gudrun, Rutsdottir, Bente, Glintborg, Helga, Westerlind, Gerdur, Grondal, Isabella C, Loft, Signe Bek, Sorensen, Benedicte A, Lie, Mikael, Brink, Lisbeth, Ärlestig, Asgeir Orn, Arnthorsson, Eva, Baecklund, Karina, Banasik, Steffen, Bank, Lena I, Bjorkman, Torkell, Ellingsen, Christian, Erikstrup, Oleksandr, Frei, Inger, Gjertsson, Daniel F, Gudbjartsson, Sigurjon A, Gudjonsson, Gisli H, Halldorsson, Oliver, Hendricks, Jan, Hillert, Estrid, Hogdall, Søren, Jacobsen, Dorte Vendelbo, Jensen, Helgi, Jonsson, Alf, Kastbom, Ingrid, Kockum, Salome, Kristensen, Helga, Kristjansdottir, Margit H, Larsen, Asta, Linauskas, Ellen-Margrethe, Hauge, Anne G, Loft, Bjorn R, Ludviksson, Sigrun H, Lund, Thorsteinn, Markusson, Gisli, Masson, Pall, Melsted, Kristjan H S, Moore, Heidi, Munk, Kaspar R, Nielsen, Gudmundur L, Norddahl, Asmundur, Oddsson, Thorunn A, Olafsdottir, Pall I, Olason, Tomas, Olsson, Sisse Rye, Ostrowski, Kim, Hørslev-Petersen, Solvi, Rognvaldsson, Helga, Sanner, Gilad N, Silberberg, Hreinn, Stefansson, Erik, Sørensen, Inge J, Sørensen, Carl, Turesson, Thomas, Bergman, Lars, Alfredsson, Tore K, Kvien, Søren, Brunak, Kristján, Steinsson, Vibeke, Andersen, Ole A, Andreassen, Solbritt, Rantapää-Dahlqvist, Merete Lund, Hetland, Lars, Klareskog, Johan, Askling, Leonid, Padyukov, Ole Bv, Pedersen, Unnur, Thorsteinsdottir, Ingileif, Jonsdottir, Kari, Stefansson

Publikováno v: Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Ärlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E-M, Loft, A G, Ludviksson, B R, Lund, S H, Ostrowski, S R, Sørensen, E, Sørensen, I J, Brunak, S, Andersen, V, Hetland, M L, Askling, J, Pedersen, O B & Members of the DBDS Genomic Consortium 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Arlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, DBDS Genomic Consortium, The Danish RA Genetics Working Group & The Swedish Rheumatology Quality Register Biobank Study Group (SRQb) 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754
Annals of the Rheumatic Diseases
Saevarsdottir, S, Stefansdottir, L, Sulem, P, Thorleifsson, G, Ferkingstad, E, Rutsdottir, G, Glintborg, B, Westerlind, H, Grondal, G, Loft, I C, Sorensen, S B, Lie, B A, Brink, M, Ärlestig, L, Arnthorsson, A O, Baecklund, E, Banasik, K, Bank, S, Bjorkman, L I, Ellingsen, T, Erikstrup, C, Frei, O, Gjertsson, I, Gudbjartsson, D F, Gudjonsson, S A, Halldorsson, G H, Hendricks, O, Hillert, J, Hogdall, E, Jacobsen, S, Jensen, D V, Jonsson, H, Kastbom, A, Kockum, I, Kristensen, S, Kristjansdottir, H, Larsen, M H, Linauskas, A, Hauge, E-M, Loft, A G, Ludviksson, B R, Lund, S H, Markusson, T, Masson, G, Melsted, P, Moore, K H S, Munk, H, Nielsen, K R, Norddahl, G L, Oddsson, A, Olafsdottir, T A, Olason, P I, Olsson, T, Ostrowski, S R, Hørslev-Petersen, K, Rognvaldsson, S, Sanner, H, Silberberg, G N, Stefansson, H, Sørensen, E, Sørensen, I J, Turesson, C, Bergman, T, Alfredsson, L, Kvien, T K, Brunak, S, Steinsson, K, Andersen, V, Andreassen, O A, Rantapää-Dahlqvist, S, Hetland, M L, Klareskog, L, Askling, J, Padyukov, L, Pedersen, O B, Thorsteinsdottir, U, Jonsdottir, I, Stefansson, K, Members of the DBDS Genomic Consortium & Nyegaard, M 2022, ' Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset ', Annals of the Rheumatic Diseases, vol. 81, no. 8, 221754, pp. 1085-1095 . https://doi.org/10.1136/annrheumdis-2021-221754

Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and similar to 1

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https://curis.ku.dk/portal/da/publications/multiomics-analysis-of-rheumatoid-arthritis-yields-sequence-variants-that-have-large-effects-on-risk-of-the-seropositive-subset(ac8972ce-4933-4e08-88e5-2da877e76a2b).html

Identification of new biomarkers to promote personalised treatment of patients with inflammatory rheumatic disease:protocol for an open cohort study

Autor: Susanne Juhl Pedersen, Heidi Munk, Hanne Merete Lindegaard, Christoffer Tandrup Holst Nielsen, Henrik Nordin, Merete Lund Hetland, Estrid Høgdall, Søren Jacobsen, Torkell Ellingsen

Publikováno v: Kringelbach, T M, Glintborg, B, Hogdall, E V, Johansen, J S, Hetland, M L, Biomarker Protocol Study Group, Schlemmer, A, Kristensen, S & Meyer, M K 2018, ' Identification of new biomarkers to promote personalised treatment of patients with inflammatory rheumatic disease : protocol for an open cohort study ', BMJ Open, vol. 8, no. 2, e019325 . https://doi.org/10.1136/bmjopen-2017-019325
Kringelbach, T M, Glintborg, B, Hogdall, E V, Johansen, J S & Hetland, M L 2018, ' Identification of new biomarkers to promote personalised treatment of patients with inflammatory rheumatic disease : Protocol for an open cohort study ', BMJ Open, vol. 8, no. 2, e019325 . https://doi.org/10.1136/bmjopen-2017-019325
Biomarker Protocol Study Group, Ellingsen, T J & Lorenzen, T 2018, ' Identification of new biomarkers to promote personalised treatment of patients with inflammatory rheumatic disease : protocol for an open cohort study ' BMJ Open, vol. 8, no. 2, e019325 . https://doi.org/10.1136/bmjopen-2017-019325
BMJ Open
Lindegaard, H M, Bjørling-Poulsen, M, Ellingsen, T J, Munk, H L & Biomarker Protocol Study Group 2018, ' Identification of new biomarkers to promote personalised treatment of patients with inflammatory rheumatic disease : protocol for an open cohort study ', BMJ Open, vol. 8, no. 2, e019325, pp. e019325 . https://doi.org/10.1136/bmjopen-2017-019325

IntroductionThe introduction of biological disease-modifying antirheumatic drugs (bDMARDs) has improved the treatment of inflammatory rheumatic diseases dramatically. However, bDMARD treatment failure occurs in 30%–40% of patients due to lack of ef

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https://vbn.aau.dk/da/publications/15ff423a-7d11-463b-9bed-654d4d6893b0

Biomarkers of Chondrocyte Activity Are Increased in Psoriasis Arthritis and Spondyloarthritis

Autor: Karoline Natasja Stæhr Gudmann, Heidi Munk, Christensen, A. F., Ejstrup, L., Grith Lykke Sørensen, Loft, A. G., Karsdal, M. A., Anne-Christine Bay Jensen, He, Y., Siebuhr, A. S., Junker, P.

Publikováno v: Gudmann, K N S, Munk, H L, Christensen, A F, Ejstrup, L, Sorensen, G L, Loft, A G, Karsdal, M A, Jensen, A-C B, He, Y, Siebuhr, A S & Junker, P 2014, ' Biomarkers of Chondrocyte Activity Are Increased in Psoriasis Arthritis and Spondyloarthritis ', Arthritis & Rheumatology, vol. 66, no. 10 (Special Issue), 629, pp. S276 . < http://onlinelibrary.wiley.com/doi/10.1002/art.v66.S10/issuetoc >
University of Southern Denmark

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1f4f4f674b9b5a65b9d45dbb448f9b09
Wiley Online Library

Type I and III collagen turnover is increased in axial spondyloarthritis and psoriatic arthritis. Associations with disease activity and diagnostic capacity

Autor: Ns, Gudmann, As, Siebuhr, Af, Christensen, Ejstrup L, Gl, Sørensen, Ag, Loft, Ma, Karsdal, Ac, Bay-Jensen, Heidi Munk, Junker P

Publikováno v: Europe PubMed Central

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http://europepmc.org/abstract/med/28240584

REMOTE AND PHYSICAL CONSULTATIONS DURING THE FIRST 15 MONTHS OF THE COVID-19 PANDEMIC: USE AND PATIENT-SATISFACTION IN PATIENTS WITH INFLAMMATORY RHEUMATIC DISEASES FOLLOWED IN THE DANBIO REGISTRY

Autor: Bente Glintborg, Dorte Vendelbo Jensen, Lene Terslev, Oliver Hendricks, Mikkel Østergaard, Rasmussen, S. H., Mogens Pfeiffer-Jensen, Thomas Adelsten, Colic, A., Danebod, K., Malene Kildemand, Loft, A. G., Heidi Munk, Jens Kristian Pedersen, Østgård, René D., Christian Møller Sørensen, Niels Steen Krogh, Jette Nørgaard Agerbo, Connie Ziegler, Merete Lund Hetland

Publikováno v: University of Southern Denmark

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https://portal.findresearcher.sdu.dk/en/publications/80eb2dde-d0e3-44ff-89a4-9b511402468f