Výsledky vyhledávání - "Heidi M. Scherch"

Direct Measurement of Lipid Hydroperoxides in Iron-Dependent Spinal Neuronal Injury

Autor: Edward D. Hall, Jue-Rong Zhang, Heidi M. Scherch

Publikováno v: Journal of Neurochemistry. 66:355-361

The relationship between iron-dependent fetal mouse spinal cord neuron injury and the generation of endogenous lipid hydroperoxides (LOOHs) has been investigated. Cultured spinal cord neurons were incubated with ferrous iron (3-200 μM). Cell viabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c9c706c9f8213a3a75194927ff5846
https://doi.org/10.1046/j.1471-4159.1996.66010355.x

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Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury

Autor: Sarah L. Smith, Edward D. Hall, Heidi M. Scherch

Publikováno v: Journal of Neurosurgery. 84:229-233

✓ The 21-aminosteroid lipid-peroxidation inhibitor, tirilazad mesylate (U-74006F), recently was shown in a large multinational Phase III clinical trial to decrease mortality and improve neurological recovery in patients 3 months after onset of aneu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff1e3b9dfc94ed2f9b4060fbd292750
https://doi.org/10.3171/jns.1996.84.2.0229

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ChemInform Abstract: Synthesis of Novel 2,4-Diaminopyrrolo(2,3-d)pyrimidines with Antioxidant, Neuroprotective, and Antiasthma Activity

Autor: G. E. Padbury, P. G. Larson, C. S. Aaron, L. S. Banitt, K. L. Linseman, J. K. Mayo, J. E. Chin, P. A. Yonkers, Heidi M. Scherch, E. D. Hall, Stephen A. Mizsak, K. L. Belonga, Gordon L. Bundy, J. M. Lin, F. F. Sun, J. M. Tustin, I. M. Richards, Donald E. Ayer, John R. Palmer

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53e41174a634527607b1c5c03a355d49
https://doi.org/10.1002/chin.199607175

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The kappa opioid-related anticonvulsants U-50488H and U-54494A attenuate N-methyl-D-aspartate induced brain injury in the neonatal rat

Autor: John S. Althaus, Christopher J. Hudson, Heidi M. Scherch, Eugene D. Means, Philip F. Von Goigtlander

Publikováno v: Brain Research. 564:261-267

The neuroprotective effects of the kappa opioid-related anticonvulsants U-50488H and U-54494A were tested in a model of N-methyl- D -aspartate (NMDA)-induced brain injury in the neonatal rat. Seven-day-old rat pups were injected intracerebrally with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc334d5822370f470c7c938d34dffcf
https://doi.org/10.1016/0006-8993(91)91462-a

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Neuroprotective Efficacy of Microvascularly-Localized Versus Brain-Penetrating Antioxidants

Autor: Gordon L. Bundy, Geri A. Sawada, Paula K. Andrus, Sarah L. Smith, J. S. Tustin, John R. Palmer, Edward D. Hall, Donald E. Ayer, Thomas J. Raub, Barry S. Lutzke, Jo A. Oostveen, Heidi M. Scherch, K. L. Belonga, L. S. Banitt

Publikováno v: Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma ISBN: 9783709194676

The 21-aminosteroid (lazaroid) tirilazad mesylate has been demonstrated to be a potent inhibitor of lipid peroxidation and to reduce traumatic and ischemic damage in a number of experimental models. Currently, tirilazad is being actively investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8124d77933406848f8de36a79d00aa7
https://doi.org/10.1007/978-3-7091-9465-2_19

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