Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Heidi M Schmidt"'
Autor:
Evan R. DeVallance, Heidi M. Schmidt, Madison Seman, Sara E. Lewis, Katherine C. Wood, Schuyler D. Vickers, Scott A. Hahn, Murugesan Velayutham, Emily A. Hileman, Dario A. Vitturi, Roberta Leonardi, Adam C. Straub, Eric E. Kelley
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102866- (2023)
We recently reported a previously unknown salutary role for xanthine oxidoreductase (XOR) in intravascular heme overload whereby hepatocellular export of XOR to the circulation was identified as a seminal step in affording protection. However, the ce
Externí odkaz:
https://doaj.org/article/87ca64a023a542648045412108a3db24
Autor:
Heidi M. Schmidt, Evan R. DeVallance, Sara E. Lewis, Katherine C. Wood, Gowtham K. Annarapu, Mara Carreño, Scott A. Hahn, Madison Seman, Brooke A. Maxwell, Emily A. Hileman, Julia Z. Xu, Murugesan Velayutham, Werner J. Geldenhuys, Dario A. Vitturi, Sruti Shiva, Eric E. Kelley, Adam C. Straub
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102636- (2023)
Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidants as a byproduct. Importantly, XO activity is elevated in numerous hemolytic conditions including sickle cell disease (SCD); howev
Externí odkaz:
https://doaj.org/article/fc1d13f5ed7a4f76bf1f12017427f9c4
Autor:
Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert Hall, Helene M. Altmann, Scott A. Hahn, Megan P. Miller, Katherine C. Wood, Bethann Gabris, Margaret C. Stapleton, Sean Hartwick, Marco Fazzari, Yijen L. Wu, Mohamed Trebak, Brett A. Kaufman, Charles F. McTiernan, Francisco J. Schopfer, Placido Navas, Patrick H. Thibodeau, Dennis M. McNamara, Guy Salama, Adam C. Straub
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes; however, the basic pathways and mechanisms governing redox homeostasis in cardiomyocytes are no
Externí odkaz:
https://doaj.org/article/347f7b78e498476bb1cd8f897c890698
Autor:
Katherine C. Wood, Brittany G. Durgin, Heidi M. Schmidt, Scott A. Hahn, Jeffrey J. Baust, Tim Bachman, Dario A. Vitturi, Samit Ghosh, Solomon F. Ofori-Acquah, Ana L. Mora, Mark T. Gladwin, Adam C. Straub
Publikováno v:
Blood Advances, Vol 3, Iss 23, Pp 4104-4116 (2019)
Abstract: Pulmonary and systemic vasculopathies are significant risk factors for early morbidity and death in patients with sickle cell disease (SCD). An underlying mechanism of SCD vasculopathy is vascular smooth muscle (VSM) nitric oxide (NO) resis
Externí odkaz:
https://doaj.org/article/b7619e205b9f4bd3ad6bf82a6e4b93ab
Publikováno v:
Redox Biology, Vol 21, Iss , Pp - (2019)
Hemolytic diseases are associated with elevated levels of circulating free heme that can mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly by upregulating enzymatic sources of reactive species. A key enzymat
Externí odkaz:
https://doaj.org/article/812e4bbad40b41a3bf4fe30007144c28
Autor:
Paul D. Chantler, Courtney B. Rosencrance, Andrew P. Giromini, Eric E. Kelley, Xena M. Williams, Adam C. Straub, Heidi M Schmidt, Evan De Vallance, Rakesh P. Patel, Joo-Yeun Oh, Sara E. Lewis
Publikováno v:
Free Radic Biol Med
A number of molybdopterin enzymes, including xanthine oxidoreductase (XOR), aldehyde oxidase (AO), sulfite oxidase (SO), and mitochondrial amidoxime reducing component (mARC), have been identified as nitrate and nitrite reductases. Of these enzymes,
Publikováno v:
Free Radical Biology and Medicine. 167:321-334
Coenzyme Q (CoQ) is ubiquitously embedded in lipid bilayers of various cellular organelles. As a redox cycler, CoQ shuttles electrons between mitochondrial complexes and extramitochondrial reductases and oxidases. In this way, CoQ is crucial for main
Autor:
Adam C. Straub, Jianhai Du, Samit Ghosh, Heidi M Schmidt, Brenda McMahon, Jeffrey D. Lebensburger, Solomon F. Ofori-Acquah, Scott A. Hahn, Yekai Wang, Joo-Yeun Oh, Shuai Yuan, Katherine C. Wood, Jeffrey J. Baust, Sara E. Lewis, Dario A. Vitturi, Eric E. Kelley, Timothy N. Bachman, Rakesh P. Patel, Xena M. Williams
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Chronic hemolysis is a hallmark of sickle cell disease (SCD) and a driver of vasculopathy; however, the mechanisms contributing to hemolysis remain incompletely understood. Although XO (xanthine oxidase) activity has been shown to be eleva
Autor:
John W. R. Kincaid, Gretchen Weiss, Anne E. Hill‐Baskin, Heidi M. Schmidt, Ovwoioise Omoijuanfo, Cheryl L. Thompson, Rose C. Beck, Nathan A. Berger
Publikováno v:
Obesity (Silver Spring, Md.). 30(7)
Obesity has emerged as a prominent risk factor for multiple serious disease states, including a variety of cancers, and is increasingly recognized as a primary contributor to preventable cancer risk. However, few studies of leukemia have been conduct
Autor:
Adam C. Straub, Heidi M Schmidt, Joseph C Galley, Shuai Yuan, Atinuke M. Dosunmu-Ogunbi, Katherine C. Wood
Publikováno v:
Hypertension
The arterial resistance vasculature modulates blood pressure and flow to match oxygen delivery to tissue metabolic demand. As such, resistance arteries and arterioles have evolved a series of highly orchestrated cell-cell communication mechanisms bet