Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Heidi M, Savage"'
Autor:
Jessica W. Chen, William Jacot, Javier Cortés, Ian E. Krop, Susan Dent, Nadia Harbeck, Michelino De Laurentiis, Véronique Diéras, Young‐Hyuck Im, Thomas J. Stout, Frauke Schimmoller, Heidi M. Savage, Katherine E. Hutchinson, Timothy R. Wilson
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2000-2016 (2023)
Taselisib is a potent β‐sparing phosphatidylinositol 3‐kinase (PI3K) inhibitor that, with endocrine therapy, improves outcomes in phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha (PIK3CA)‐mutated (PIK3CAmut) advance
Externí odkaz:
https://doaj.org/article/535a6a7921404a8298c1f95b55637007
Autor:
Katherine E. Hutchinson, Jessica W. Chen, Heidi M. Savage, Thomas J. Stout, Frauke Schimmoller, Javier Cortés, Susan Dent, Nadia Harbeck, William Jacot, Ian Krop, Sally E. Trabucco, Smruthy Sivakumar, Ethan S. Sokol, Timothy R. Wilson
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Mutations in the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K), encoded by the PIK3CA gene, cause dysregulation of the PI3K pathway in 35–40% of patients with HR+/HER2– breast cancer. Preclinically, cancer c
Externí odkaz:
https://doaj.org/article/6a84c1824dfc43c99cd063f56d446e86
Autor:
Timothy R. Wilson, Mark R. Lackner, Lori S. Friedman, Ciara Metcalfe, Michael E. Goldberg, Ethan S. Sokol, Wei Zhou, Carol O'Brien, Heidi M. Savage, Heather M. Moore
Supplementary Figure S7: MCF-7 DOX-inducible ER-alpha overexpressing cells without DOX induction respond similarly to taselisib and/or fulvestrant as MCF-7 parental cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1323ac6db0d9fe0223a192df2d5d72c5
https://doi.org/10.1158/1535-7163.22505926.v1
https://doi.org/10.1158/1535-7163.22505926.v1
Autor:
Mark R. Lackner, Richard Bourgon, Joyce A. O'Shaughnessy, Anneleen Daemen, Heidi M. Savage, Junko Aimi, Jill M. Spoerke, Ching-Wei Chang, Akshata R. Udyavar, Timothy R. Wilson
The identification of early breast cancer patients who may benefit from adjuvant chemotherapy has evolved to include assessment of clinicopathologic features such as tumor size and nodal status, as well as several gene-expression profiles for ER-posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39a64bbe20881e43c149267b4b8c8c49
https://doi.org/10.1158/1541-7786.c.6541339
https://doi.org/10.1158/1541-7786.c.6541339
Autor:
Mark R. Lackner, Richard Bourgon, Joyce A. O'Shaughnessy, Anneleen Daemen, Heidi M. Savage, Junko Aimi, Jill M. Spoerke, Ching-Wei Chang, Akshata R. Udyavar, Timothy R. Wilson
Supplemental Methods describing NGS and gene expression studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799c9f8523717724930ef44fb34e8379
https://doi.org/10.1158/1541-7786.22516291
https://doi.org/10.1158/1541-7786.22516291
Autor:
José Baselga, Daniel D. Von Hoff, Jerry Y. Hsu, Hema Parmar, Huan Jin, Ray S. Lin, Laurent Salphati, Deepak Sampath, Heidi M. Savage, Sandra M. Sanabria Bohorquez, Joseph A. Ware, Timothy R. Wilson, Ramesh K. Ramanathan, Ian Krop, Dejan Juric
Supplementary Table S1. Patient Demographics and Disease Characteristics. Supplementary Table S2. Treatment-Related Adverse Events of Grade 3 or Higher Observed in either Cycle 1 or Cycle greater than or equal to 2. Supplementary Table S3. Adverse Ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08231e12877ec97d91ac400e1e431122
https://doi.org/10.1158/2159-8290.22532083.v1
https://doi.org/10.1158/2159-8290.22532083.v1
Autor:
Mark R. Lackner, Richard Bourgon, Joyce A. O'Shaughnessy, Anneleen Daemen, Heidi M. Savage, Junko Aimi, Jill M. Spoerke, Ching-Wei Chang, Akshata R. Udyavar, Timothy R. Wilson
FoundationOne sequencing data for n=399 breast cancer population. Each sheet contains a distinct type of alteration. The clinical covariates used in our analysis are included.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e880847674b3791a18e9cc43632fc8
https://doi.org/10.1158/1541-7786.22516285.v1
https://doi.org/10.1158/1541-7786.22516285.v1
Autor:
Mark R. Lackner, Richard Bourgon, Joyce A. O'Shaughnessy, Anneleen Daemen, Heidi M. Savage, Junko Aimi, Jill M. Spoerke, Ching-Wei Chang, Akshata R. Udyavar, Timothy R. Wilson
Enriched Pathway Analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec4c50c9b927c99d31f4ab45cc41bd7
https://doi.org/10.1158/1541-7786.22516297.v1
https://doi.org/10.1158/1541-7786.22516297.v1
Autor:
Mark R. Lackner, Richard Bourgon, Joyce A. O'Shaughnessy, Anneleen Daemen, Heidi M. Savage, Junko Aimi, Jill M. Spoerke, Ching-Wei Chang, Akshata R. Udyavar, Timothy R. Wilson
Supplemental figures 1,2,4-8 as supporting figures to the manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0b3eca8f8e6070de6106c236e5fec2
https://doi.org/10.1158/1541-7786.22516294
https://doi.org/10.1158/1541-7786.22516294
Autor:
David M. Hyman, Michael C. Wei, Timothy R. Wilson, Maurizio Scaltriti, Heidi M. Savage, Surai Jones, John Bond, Helen Won, Lara Dunn, Jasgit C. Sachdev, Philippe L. Bedard, Raid Aljumaily, Cynthia X. Ma, Vincent Ribrag, Manish R. Patel, Anton Melnyk, Valentina Gambardella, Cristina Saura, Dejan Juric, Matthew T. Chang, Komal Jhaveri
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b61946403042657dff6a32ae72420c
https://doi.org/10.1158/1078-0432.22479515.v1
https://doi.org/10.1158/1078-0432.22479515.v1