Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Heidi L. Shimp"'
Publikováno v:
The Journal of Organic Chemistry. 74:7211-7219
A highly selective convergent coupling reaction is described between alkynes for the synthesis of stereodefined trisubstituted (E,E)-1,3-dienes-structural motifs commonly found embedded in the skeletons of bioactive polyketide-derived natural product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674b9441500d8faa14fab2269d57265d
https://doi.org/10.1021/jo901451c
https://doi.org/10.1021/jo901451c
Autor:
Heidi L. Shimp, Glenn C. Micalizio
Publikováno v:
Tetrahedron. 65:5908-5915
A convergent formal synthesis of the antimitotic macrolide dictyostatin has been achieved. The C11–C26 fragment of dictyostatin was prepared via convergent assembly of the central deoxypropionate motif utilizing a site- and stereoselective titanium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::080992a0f00d43d486c573e1e6f0bf61
https://doi.org/10.1016/j.tet.2009.04.073
https://doi.org/10.1016/j.tet.2009.04.073
Publikováno v:
Tetrahedron. 64:6831-6837
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad36fc760eebdeae0ff489e6ae20c5dd
https://doi.org/10.1016/j.tet.2008.03.086
https://doi.org/10.1016/j.tet.2008.03.086
Autor:
Vanessa L. Sherman, M. Reza Anari, Catherine M. Wiscount, Julie A. Krueger, Christopher J. Kochansky, Bobby J. Lucas, Tran Lekhanh O, Joseph P. Vacca, Terry A. Lyle, Bradley K. Wong, Sanderson Philip E, Heidi L. Shimp, Peter D. Williams, Sean Yu, Donnette D. Staas, Kelly L. Savage, S. Dale Lewis, Rebecca B. White, Youwei Yan, Daniel R. McMasters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:6900-6916
Previous reports from our laboratories described potent tripeptide thrombin inhibitors which incorporate heterocycle-substituted chlorophenyl groups in the P1 position. Using these as lead compounds for further optimization, we identified sites of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0f376b03a161dd0c0e74d58d1df6a5
https://doi.org/10.1016/j.bmc.2006.06.040
https://doi.org/10.1016/j.bmc.2006.06.040
Autor:
Heidi L. Shimp, Eduard G. Casillas, Catherine E. Leimkuhler, Lindsay A. Curtis, Justin K. Belardi, Steven S. Clareen, Nicole L. Simonowicz
Publikováno v:
Synthetic Communications. 35:1633-1640
A short, scalable route to 4‐hydroxymethylcyclopent‐2‐enone, based upon a silicon‐directed Nazarov cyclization, is described. Noteworthy in this study is the success of the cyclization with an oxygenated substrate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eda4260d372d5b85ebf0dcf772b1830a
https://doi.org/10.1081/scc-200061633
https://doi.org/10.1081/scc-200061633
Publikováno v:
ChemInform. 41
A highly selective convergent coupling reaction is described between alkynes for the synthesis of stereodefined trisubstituted (E,E)-1,3-dienes-structural motifs commonly found embedded in the skeletons of bioactive polyketide-derived natural product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92ed65386da21cc43f1ffbf99ab1aab3
https://doi.org/10.1002/chin.201007045
https://doi.org/10.1002/chin.201007045
Autor:
Heidi L. Shimp, Glenn C. Micalizio
Publikováno v:
ChemInform. 40
A convergent formal synthesis of the antimitotic macrolide dictyostatin has been achieved. The C11–C26 fragment of dictyostatin was prepared via convergent assembly of the central deoxypropionate motif utilizing a site- and stereoselective titanium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7248ad269ef3078c482730b06fffef2
https://doi.org/10.1002/chin.200946207
https://doi.org/10.1002/chin.200946207
Publikováno v:
ChemInform. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aa930db717067931a7d4fc56ede824b
https://doi.org/10.1002/chin.200906053
https://doi.org/10.1002/chin.200906053
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cddef2011b7a33c62965fddafcd1f59
https://doi.org/10.1002/chin.200840057
https://doi.org/10.1002/chin.200840057
Publikováno v:
ChemInform. 39
We describe a titanium-mediated reaction for the convergent coupling of allenic alcohols with aromatic imines. Overall, the bond formation occurs at the central carbon of the allene, proceeds with net allylic transposition, and provides substituted 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7ed5ae68cc8654a6d1292b2941601b
https://doi.org/10.1002/chin.200831083
https://doi.org/10.1002/chin.200831083