Výsledky vyhledávání - "Heidi L. M. De Gruyter"

Akademický článek

The Main Protease of Middle East Respiratory Syndrome Coronavirus Induces Cleavage of Mitochondrial Antiviral Signaling Protein to Antagonize the Innate Immune Response

Autor: Mariska van Huizen, Xavier M. Vendrell, Heidi L. M. de Gruyter, A. Linda Boomaars-van der Zanden, Yvonne van der Meer, Eric J. Snijder, Marjolein Kikkert, Sebenzile K. Myeni

Publikováno v: Viruses, Vol 16, Iss 2, p 256 (2024)

Mitochondrial antiviral signaling protein (MAVS) is a crucial signaling adaptor in the sensing of positive-sense RNA viruses and the subsequent induction of the innate immune response. Coronaviruses have evolved multiple mechanisms to evade this resp

Externí odkaz: https://doaj.org/article/388619a410d14801905fa0b17bb0ff34

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Safety and immunogenicity of a modified-vaccinia-virus-Ankara-based influenza A H5N1 vaccine

Autor: Asisa Volz, Ron A. M. Fouchier, Guus F. Rimmelzwaan, Michael H. Lehmann, Marco Goeijenbier, Heidi L. M. De Gruyter, Fleur M. Moesker, Albert D. M. E. Osterhaus, David A. M. C. van de Vijver, Gerd Sutter, Gerrie de Mutsert, Joost H. C. M. Kreijtz, Lennert W. J. van den Dries, Simone Goeijenbier, Eric C. M. van Gorp

Publikováno v: The Lancet Infectious Diseases, 14(12), 1196-207. Lancet Publishing Group

BACKGROUND: Modified vaccinia virus Ankara (MVA) is a promising viral vector platform for the development of an H5N1 influenza vaccine. Preclinical assessment of MVA-based H5N1 vaccines showed their immunogenicity and safety in different animal model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19327f7a6eea423dfe59e896ab09d1f
https://doi.org/10.1016/s1473-3099(14)70963-6

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A Single Immunization With Modified Vaccinia Virus Ankara-Based Influenza Virus H7 Vaccine Affords Protection in the Influenza A(H7N9) Pneumonia Ferret Model

Autor: Geert van Amerongen, Stella E. Vogelzang-van Trierum, Lidewij Wiersma, Joost H. C. M. Kreijtz, Albert D. M. E. Osterhaus, Heidi L. M. De Gruyter, Guus F. Rimmelzwaan, Ron A. M. Fouchier, Koert J. Stittelaar, Gerd Sutter

Publikováno v: Journal of Infectious Diseases, 211(5), 791-800. Oxford University Press

Since the first reports in early 2013, >440 human cases of infection with avian influenza A(H7N9) have been reported including 122 fatalities. After the isolation of the first A(H7N9) viruses, the nucleotide sequences became publically available. Bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42efa455ff768585a8053eaf1645973e
https://doi.org/10.1093/infdis/jiu528

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Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice

Autor: Kenny Roose, Stella E. van Trierum, Arwen F. Altenburg, Rory D. de Vries, Heidi L. M. De Gruyter, Carolien E. van de Sandt, Gerd Sutter, Xavier Saelens, Guus F. Rimmelzwaan, Ron A. M. Fouchier, Asisa Volz, Peter van Run

Publikováno v: Journal of Virology, 90(22), 10209-10219. American Society for Microbiology

Due to antigenic drift of influenza viruses, seasonal influenza vaccines need to be updated annually. These vaccines are based on predictions of strains likely to circulate in the next season. However, vaccine efficacy is greatly reduced in the case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed44b3e3d50f2e0ac3d0985f96f99413
https://pubmed.ncbi.nlm.nih.gov/27581985

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Induction of Influenza (H5N8) Antibodies by Modified Vaccinia Virus Ankara H5N1 Vaccine

Autor: Ron A. M. Fouchier, Gerd Sutter, Guus F. Rimmelzwaan, Theo M. Bestebroer, Mark Pronk, Albert D. M. E. Osterhaus, Joost H. C. M. Kreijtz, Rory D. de Vries, Heidi L. M. De Gruyter

Publikováno v: Emerging Infectious Diseases, 21(6), 1086-1088. Centers for Disease Control and Prevention (CDC)
Emerging Infectious Diseases, Vol 21, Iss 6, Pp 1086-1088 (2015)
Emerging Infectious Diseases

To the Editor: Aquatic birds form a natural reservoir of avian influenza viruses from which new human and animal influenza viruses originate. After initial detection in 2010 in China, a new highly pathogenic avian influenza (HPAI) virus of the H5N8 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ca09a830eeb808ee3403ae8ab342a8
https://pure.eur.nl/en/publications/6e1420dd-960f-4d5a-a0f5-c04aa18dd8b0

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Akademický článek

Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo.

Autor: Mariska van Huizen, Jonna R Bloeme-Ter Horst, Heidi L M de Gruyter, Paul P Geurink, Gerbrand J van der Heden van Noort, Robert C M Knaap, Tessa Nelemans, Natacha S Ogando, Anouk A Leijs, Nadya Urakova, Brian L Mark, Eric J Snijder, Sebenzile K Myeni, Marjolein Kikkert

Publikováno v: PLoS Pathogens, Vol 20, Iss 3, p e1012100 (2024)

The coronavirus papain-like protease (PLpro) is crucial for viral replicase polyprotein processing. Additionally, PLpro can subvert host defense mechanisms by its deubiquitinating (DUB) and deISGylating activities. To elucidate the role of these acti

Externí odkaz: https://doaj.org/article/7f36d353de494643ab5436ca01691fdd

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