Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Heidi L. Kenerson"'
Autor:
Sophia M. Lauer, Mitchell H. Omar, Martin G. Golkowski, Heidi L. Kenerson, Kyung-Soon Lee, Bryan C. Pascual, Huat C. Lim, Katherine Forbush, F. Donelson Smith, John D. Gordan, Shao-En Ong, Raymond S. Yeung, John D. Scott
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113678- (2024)
Summary: The DNAJ-PKAc fusion kinase is a defining feature of fibrolamellar carcinoma (FLC). FLC tumors are notoriously resistant to standard chemotherapies, with aberrant kinase activity assumed to be a contributing factor. By combining proximity pr
Externí odkaz:
https://doaj.org/article/0017dacb347145b2ba79f18c4ba57c47
Autor:
Lindsay C. Czuba, Xia Wu, Weize Huang, Nicole Hollingshead, Jessica B. Roberto, Heidi L. Kenerson, Raymond S. Yeung, Ian N. Crispe, Nina Isoherranen
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 976-989 (2021)
Abstract All‐trans‐retinoic acid (atRA), the active metabolite of vitamin A, has antifibrogenic properties in vitro and in animal models. Liver vitamin A homeostasis is maintained by cell‐specific enzymatic activities including storage in hepat
Externí odkaz:
https://doaj.org/article/34b049063fdf462bbd6d0416bfd3488f
Autor:
Xia Wu, Jessica B. Roberto, Allison Knupp, Alexander L. Greninger, Camtu D. Truong, Nicole Hollingshead, Heidi L. Kenerson, Marianne Tuefferd, Antony Chen, David M. Koelle, Helen Horton, Keith R. Jerome, Stephen J. Polyak, Raymond S. Yeung, Ian N. Crispe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Precision-cut human liver slice cultures (PCLS) have become an important alternative immunological platform in preclinical testing. To further evaluate the capacity of PCLS, we investigated the innate immune response to TLR3 agonist (poly-I:C) and TL
Externí odkaz:
https://doaj.org/article/75336c7dd31743c385e9d9eee84beec0
Autor:
Heidi L. Kenerson, Kevin M. Sullivan, Kevin P. Labadie, Venu G. Pillarisetty, Raymond S. Yeung
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100574- (2021)
Summary: The impact of systemic therapy on the tumor microenvironment has been difficult to study in human solid tumors. Our protocol describes steps for establishing slice cultures to investigate response to chemotherapies, immunotherapies, or adopt
Externí odkaz:
https://doaj.org/article/1fef7fe50ad6476a9f8d210e0453e5c6
Autor:
Laura J. den Hartigh, Leela Goodspeed, Shari A. Wang, Heidi L. Kenerson, Mohamed Omer, Kevin D. O'Brien, Warren Ladiges, Raymond Yeung, Savitha Subramanian
Publikováno v:
Experimental Physiology, Vol 103, Iss 11, Pp 1469-1480 (2018)
New Findings What is the central question of this study? Whether chronic oral rapamycin promotes beneficial effects on glucose/lipid metabolism and energy balance when administered to mice with an obesogenic diet rich in saturated fat and sucrose has
Externí odkaz:
https://doaj.org/article/0d1ac30dac254f139ce9ae2ee60b9052
Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery
Autor:
Ramya Sivakumar, Marina Chan, Jiye Stella Shin, Nao Nishida-Aoki, Heidi L. Kenerson, Olivier Elemento, Himisha Beltran, Raymond Yeung, Taranjit S. Gujral
Publikováno v:
OncoImmunology, Vol 8, Iss 12 (2019)
Organotypic tumor slices represent a physiologically-relevant culture system for studying the tumor microenvironment. Systematic characterization of the tumor slice culture system will enable its effective application for translational research. Here
Externí odkaz:
https://doaj.org/article/9c72ba7fdcd04e50aee7360dda5c3acf
Autor:
Rigney E Turnham, F Donelson Smith, Heidi L Kenerson, Mitchell H Omar, Martin Golkowski, Irvin Garcia, Renay Bauer, Ho-Tak Lau, Kevin M Sullivan, Lorene K Langeberg, Shao-En Ong, Kimberly J Riehle, Raymond S Yeung, John D Scott
Publikováno v:
eLife, Vol 8 (2019)
Fibrolamellar carcinoma (FLC) is a rare liver cancer. FLCs uniquely produce DNAJ-PKAc, a chimeric enzyme consisting of a chaperonin-binding domain fused to the Cα subunit of protein kinase A. Biochemical analyses of clinical samples reveal that a un
Externí odkaz:
https://doaj.org/article/df0373e02b8847ebb7435e13a15b41eb
Autor:
Gary KL Chan, Samantha Maisel, Yeonjoo C Hwang, Bryan C Pascual, Rebecca RB Wolber, Phuong Vu, Krushna C Patra, Mehdi Bouhaddou, Heidi L Kenerson, Huat C Lim, Donald Long, Raymond S Yeung, Praveen Sethupathy, Danielle L Swaney, Nevan J Krogan, Rigney E Turnham, Kimberly J Riehle, John D Scott, Nabeel Bardeesy, John D Gordan
Publikováno v:
eLife. 12
Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood. We used global phosphoproteomics and kinase activity profiling to map conserved signal
Autor:
Gary KL Chan, Samantha Maisel, Yeonjoo C Hwang, Bryan C Pascual, Rebecca RB Wolber, Phuong Vu, Krushna C Patra, Mehdi Bouhaddou, Heidi L Kenerson, Huat C Lim, Donald Long, Raymond S Yeung, Praveen Sethupathy, Danielle L Swaney, Nevan J Krogan, Rigney E Turnham, Kimberly J Riehle, John D Scott, Nabeel Bardeesy, John D Gordan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57702eaa8f41296e52fffc2f1b15a79
https://doi.org/10.7554/elife.69521.sa2
https://doi.org/10.7554/elife.69521.sa2
Autor:
Donald K. Hamlin, Sara K. Daniel, Kevin P. Labadie, Andrew D. Ludwig, Delphine L. Chen, Heidi L. Kenerson, Chris Orvig, Yawen Li, Lily Li, Jonathan G. Sham, D. Scott Wilbur, Raymond S. Yeung, Aimee L. Kenoyer, Johnnie J. Orozco, James O. Park, Alan F. Utria
Publikováno v:
Journal of Nuclear Medicine. 63:1033-1038
Hepatocellular carcinoma (HCC) is a significant cause of morbidity and mortality worldwide with limited therapeutic options for advanced disease. Targeted alpha therapy (TAT) is an emerging class of targeted cancer therapy in which alpha-particle-emi