Engineering of a membrane-triggered activity switch in coagulation factor VIIa

Autor: Jens Buchardt, Heidi L. Holmberg, Johan Karlsson, Mads Kjelgaard-Hansen, Kasper Lamberth, Anders B. Sorensen, Wolfram Ruf, Prafull S. Gandhi, Carsten Dan Ley, Brit B. Sørensen, Anders Lærke Nielsen, Henrik Østergaard, Ole Hvilsted Olsen

Publikováno v: Proceedings of the National Academy of Sciences. 114:12454-12459

Recombinant factor VIIa (FVIIa) variants with increased activity offer the promise to improve the treatment of bleeding episodes in patients with inhibitor-complicated hemophilia. Here, an approach was adopted to enhance the activity of FVIIa by sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf0681d039e3e21fd96e4f18b164330
https://doi.org/10.1073/pnas.1618713114

Modulation of the activated protein C pathway in severe haemophilia A patients: The effects of thrombomodulin and a factor V-stabilizing fab

Autor: Erika J. Martin, Janice Kuhn, M. E. Nolte, John C. Barrett, Rune Salbo, Donald F. Brophy, Emily K. Waters, Jacob Lund, Heidi L. Holmberg, Bo Wiinberg, Bassem M. Mohammed

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 23(6)

Introduction The thrombomodulin (TM)/activated protein C (APC) system is a key regulator of haemostasis, limiting amplification and propagation of the formed blood clot to the injury site. Dampening APC's inhibition of factor V (FV) and factor VIII (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a48f747f8f352041130acfeb27d66d0
https://pubmed.ncbi.nlm.nih.gov/28750471

GlycoPEGylated rFVIIa (N7‐GP) has a prolonged hemostatic effect in hemophilic mice compared with rFVIIa

Autor: Søren E. Bjørn, D. M. Karpf, Henning R. Stennicke, Mirella Ezban, Torben Elm, Heidi L. Holmberg, Mikael Tranholm

Publikováno v: Journal of Thrombosis and Haemostasis. 9:1070-1072

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f4ce8c3ec2983eff635d1e241e9625a
https://doi.org/10.1111/j.1538-7836.2011.04252.x

Impact of blood sampling technique on blood quality and animal welfare in haemophilic mice

Autor: Maria Kristina Kiersgaard, Lars Friis Mikkelsen, Heidi L. Holmberg, Mikael Tranholm

Publikováno v: Laboratory animals. 45(2)

Blood collection in mice can be a challenge, in particular for samples used for coagulation analysis as initiation of coagulation during the procedures can influence the results. Blood collection from the retrobulbar venous plexus is commonly used bu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24175f0d00ae749ae94e85b98e5e8a18
https://pubmed.ncbi.nlm.nih.gov/21382833

Acute Passivation of vulnerable plaques with wild-type apolipoprotein A-I in apoE-deficient mice

Autor: Jacob Marsvin Laurberg, Jonas Heilskov Graversen, Søren K. Moestrup, Heidi L. Holmberg, Erling Falk

Publikováno v: Laurberg, J M, Graversen, J H, Moestrup, S K, Holmberg, H L & Falk, E 2007, ' Acute Passivation of vulnerable plaques with wild-type apolipoprotein A-I in apoE-deficient mice. ', Vascular Disease Prevention, vol. 4, pp. 314-21 .
Laurberg, J M, Graversen, J H, Moestrup, S K, Holmberg, H L & E., F 2007, ' Acute Passivation of Vulnerable Plaques with Wild-Type Apolipoprotein A-I in ApoE-Deficient Mice ', Vascular Disease Prevention, vol. 4, no. 4, pp. 314-321 . https://doi.org/10.2174/1567270010704040314

Objective: The apolipoprotein A-I (apoA-I) variant apoA-IMilano has rapid passivating effects on atherosclerotic plaques. In this study we tested if human wild-type apoA-I can likewise rapidly mobilize cholesterol and reduce inflammation and lipid co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5bf3e1a54286e6c4d8fd024d5b7923
https://pure.au.dk/portal/da/publications/acute-passivation-of-vulnerable-plaques-with-wildtype-apolipoprotein-ai-in-apoedeficient-mice(a1d9c220-e123-11dc-9afb-000ea68e967b).html