Výsledky vyhledávání - "Heidi L. Fraser"

Akademický článek

A new approach to the pyrrolo[3,4-b]indole ring system

Autor: Jeanese C. Badenock, Heidi L. Fraser, Gordon W. Gribble

Publikováno v: ARKIVOC, Vol 2018, Iss 5, Pp 140-149 (2018)

Externí odkaz: https://doaj.org/article/cab889462ece42b4af837ece0433d314

The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)

Autor: Xin Han, Charles Ingalls, Russell Dushin, Middleton Brawner Floyd, Thomas Nittoli, Katherine Cheung, Yongbo Hu, K T Arndt, G. Grosu, Bing Guo, Heidi L. Fraser, Allan Wissner, Andrea Olland

Publikováno v: European Journal of Medicinal Chemistry. 45:1379-1386

A series of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamine-based inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1) has been identified. Several examples appear to be potent and relatively selective inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a386fbdfbe585a340f415a4ed8d9f4f
https://doi.org/10.1016/j.ejmech.2009.12.036

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Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2

Autor: Frank Loganzo, Charles Ingalls, Thomas Nittoli, Xingzhi Tan, M. Brawner Floyd, Heidi L. Fraser, Kinwang Cheung, Allan Wissner, Russell Dushin, Malini Ravi

Publikováno v: Bioorganic & Medicinal Chemistry. 15:3635-3648

A series of 4-dimethylamino-but-2-enoic acid [4-(3,6-dioxo-cyclohexa-1,4-dienylamino)-7-ethoxy-quinazolin-6-yl]-amide derivatives were prepared. These compounds have two independent reactive centers and were designed to function as dual irreversible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1f21bf3ef3cc01162085413a183083
https://doi.org/10.1016/j.bmc.2007.03.055

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A synthesis of 6,11-disubstituted benzo[b]carbazoles

Autor: Heidi L. Fraser, Gordon W. Gribble

Publikováno v: Canadian Journal of Chemistry. 79:1515-1521

Sequential regioselective addition of organolithium reagents to indolo[1,2-b]isoquinoline-6,11-quinone (7) followed by sodium borohydride reduction of the intermediate diol 10, which is not isolated, affords 6,11-disubstituted 5H-benzo[b]carbazoles 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::547d4d34377ed6fb21fc244b813b9eb9
https://doi.org/10.1139/v01-127

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ChemInform Abstract: A Novel Radical Cyclization of 2-Bromoindoles. Synthesis of Hexahydropyrrolo[3,4-b]indoles

Autor: Heidi L. Fraser, Gordon W. Gribble, Jeanese C. Badenock

Publikováno v: ChemInform. 32

Hexahydropyrrolo[3,4-b]indoles 6, 10, and 13 are obtained from 2-bromo-3-carboxamides 5, 9, and 12, respectively, by a 1,5-radical translocation process followed by 5-endo-trig cyclization to the indole C-2 position.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4981bda144e46f3ddda608f28b100d94
https://doi.org/10.1002/chin.200135036

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Benzo[c][2,7]naphthyridines as inhibitors of PDK-1

Autor: Russell Dushin, Allan Wissner, Yanong D. Wang, Andrea Olland, Kyung-Hee Kim, Heidi L. Fraser, Bing Guo, K T Arndt, Yongbo Hu, Middleton Brawner Floyd

Publikováno v: Bioorganicmedicinal chemistry letters. 19(17)

A series of substituted benzo[c][2,7]-naphthyridines were prepared and showed good potency in inhibiting PDK-1. The synthesis and SAR of this series of compounds are presented as well as the X-ray crystal structure of one of these analogs in a comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5027ee645e04336996ec000ecfa89990
https://pubmed.ncbi.nlm.nih.gov/19628388

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