Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Heidi Koldsø"'
Autor:
Mikkel Vestergaard, Nils Anton Berglund, Pin-Chia Hsu, Chen Song, Heidi Koldsø, Birgit Schiøtt, Mark S. P. Sansom
Publikováno v:
ACS Omega, Vol 4, Iss 20, Pp 18889-18899 (2019)
Externí odkaz:
https://doaj.org/article/2800c97b623748a18240b3c4f85c8be3
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 10, p e1003911 (2014)
Cell membranes are complex multicomponent systems, which are highly heterogeneous in the lipid distribution and composition. To date, most molecular simulations have focussed on relatively simple lipid compositions, helping to inform our understandin
Externí odkaz:
https://doaj.org/article/d950336904b948799da4ec62ebc64cba
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e63635 (2013)
The competitive inhibitor cocaine and the non-competitive inhibitor ibogaine induce different conformational states of the human serotonin transporter. It has been shown from accessibility experiments that cocaine mainly induces an outward-facing con
Externí odkaz:
https://doaj.org/article/15852a9b59a946118bd49b838b5e7238
Autor:
Heidi Koldsø, Pernille Noer, Julie Grouleff, Henriette Elisabeth Autzen, Steffen Sinning, Birgit Schiøtt
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 10, p e1002246 (2011)
Monoamine transporters are responsible for termination of synaptic signaling and are involved in depression, control of appetite, and anxiety amongst other neurological processes. Despite extensive efforts, the structures of the monoamine transporter
Externí odkaz:
https://doaj.org/article/ea615afbb6e44450ad5101ad34d9c062
Autor:
Heidi Koldsø, Pin-Chia Hsu, Mikkel Vestergaard, Chen Song, Birgit Schiøtt, Mark S.P. Sansom, Nils A. Berglund
Publikováno v:
Vestergaard, M, Berglund, N A, Hsu, P C, Song, C, Koldsø, H, Schiøtt, B & Sansom, M S P 2019, ' Structure and Dynamics of Cinnamycin-Lipid Complexes : Mechanisms of Selectivity for Phosphatidylethanolamine Lipids ', ACS Omega, vol. 4, no. 20, pp. 18889-18899 . https://doi.org/10.1021/acsomega.9b02949
ACS Omega, Vol 4, Iss 20, Pp 18889-18899 (2019)
ACS Omega
ACS Omega, Vol 4, Iss 20, Pp 18889-18899 (2019)
ACS Omega
Cinnamycin is a lantibiotic peptide, which selectively binds to and permeabilizes membranes containing phosphatidylethanolamine (PE) lipids. As PE is a major component of many bacterial cell membranes, cinnamycin has considerable potential for destro
Autor:
Poul Nissen, Pontus Gourdon, Henriette Elisabeth Autzen, Mark S.P. Sansom, Phillip J. Stansfeld, Heidi Koldsø
Publikováno v:
Autzen, H E, Koldsø, H, Stansfeld, P J, Gourdon, P, Sansom, M S P & Nissen, P 2018, ' Interactions of a Bacterial Cu(I)-ATPase with a Complex Lipid Environment ', Biochemistry, vol. 57, no. 28, pp. 4063-4073 . https://doi.org/10.1021/acs.biochem.8b00326
Phospholipids and sterols play multiple roles in cells. In addition to establishing barriers between compartments, they also provide the matrix for assembly and function of a large variety of catalytic processes. Lipid composition is a highly regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98a5121e4bd0863fbc08114ab17b74e
https://ora.ox.ac.uk/objects/uuid:ded48aef-67bf-497f-a83d-d4d14247dcd7
https://ora.ox.ac.uk/objects/uuid:ded48aef-67bf-497f-a83d-d4d14247dcd7
Publikováno v:
The Journal of Physical Chemistry B. 120:8873-8881
The cytoskeleton underlying cell membranes may influence the dynamic organization of proteins and lipids within the bilayer by immobilizing certain transmembrane (TM) proteins and forming corrals within the membrane. Here, we present coarse-grained r
Autor:
Heidi Koldsø, Anders Kolind, Maja Thim Larsen, Steffen Sinning, Louise M. Besenbacher, Henrik H. Jensen, Anne Brinkø, Birgit Schiøtt
Publikováno v:
Brinkø, A, Larsen, M T, Koldsø, H, Besenbacher, L M, Kolind, A, Schiøtt, B, Sinning, S & Jensen, H H 2016, ' Synthesis and inhibitory evaluation of 3-linked imipramines for the exploration of the S2 site of the human serotonin transporter ', Bioorganic & Medicinal Chemistry, vol. 24, pp. 2725-2738 . https://doi.org/10.1016/j.bmc.2016.04.039
The human serotonin transporter is the primary target of several antidepressant drugs, and the importance of a primary, high affinity binding site (S1) for antidepressant binding is well documented. The existence of a lower affinity, secondary bindin
Publikováno v:
Biochimie
Glycolipids are key components of mammalian cell membranes, influencing a diverse range of cellular functions. For example, a number of receptor tyrosine kinases, including the epidermal growth factor receptor (EGFR), are allosterically regulated by
Autor:
Anna L. Duncan, Tyler Reddy, Heidi Koldsø, Jean Hélie, Philip W. Fowler, Matthieu Chavent, Mark S. P. Sansom
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Cell membranes are crowded and complex environments. To investigate the effect of protein-lipid interactions on dynamic organization in mammalian cell membranes, we have performed coarsegrained molecular dynamics simulations containing >100 copies of