Výsledky vyhledávání - "Heidi K. Walter"

Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Autor: Felix Kratz, Federico Medda, Javier Garcia Fernandez, Heidi K. Walter, Friederike I. Nollmann, Lara Pes, Magnusson Johannes Pall, Koester Stephan David, Patricia Perez Galan, Khalid Abu Ajaj, Serghei Chercheja, Anna Warnecke

Publikováno v: Cancer Research. 78:1657-1657

Introduction and objectives: Maytansine and its analogs (DM1 and DM4) are potent microtubule-targeting compounds that inhibit proliferation of cells during mitosis.1 Unfortunately, their narrow therapeutic window prevents a clinical application of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::466f9ca4145cfa741a9f3a066beaeb70
https://doi.org/10.1158/1538-7445.am2018-1657

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Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Autor: Javier Garcia Fernandez, Lara Pes, Heidi K. Walter, Friederike I. Nollmann, Federico Medda, Magnusson Johannes Pall, Felix Kratz, Anna Warnecke, Koester Stephan David, Serghei Chercheja, Patricia Perez Galan, Khalid Abu Ajaj

Publikováno v: Cancer Research. 78:2661-2661

Introduction and objectives: Maytansine and its analogs (DM1 and DM4) are potent microtubule-targeting compounds that inhibit proliferation of cells during mitosis. Their potent anticancer activity made them attractive for drug development.1 Unfortun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f3ca8028e33eeb29be5711cb138dc59
https://doi.org/10.1158/1538-7445.am2018-2661

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